2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C25H15NO9
Simultaneous Sensitive MEKC-LIF Determination of Homocysteine, Homoarginine, and Six Arginine Metabolic Derivatives in Fluids from Type 2 Diabetics with Peptic Ulcer Bleeding was written by Liang, Qianping;Chen, Hongchao;Li, Fuqing;Du, Xiaolin. And the article was included in Chromatographia in 2015.Computed Properties of C25H15NO9 This article mentions the following:
The suitability of micellar electrokinetic capillary chromatog. (MEKC) with laser-induced fluorescence (LIF) detection for simultaneous determination of two arginine analogs (homocysteine and homoarginine) and five closely related metabolites (asym. dimethyl-L-arginine, dimethyl-L-arginine, monomethyl-L-arginine, citrulline, and ornithine) in fluids from type 2 diabetics with peptic ulcer bleeding (PUB) has been studied. 5-Carboxyfluorescein succinimidyl ester (CFSE) was chosen as the fluorescent labeling reagent and non-endogenous phenylpropanolamine (PPA) as the internal standard Conditions affecting derivatization and separation were optimized. Under the optimum conditions, maximum derivatization could be achieved in 20 min at room temperature Complete baseline separation was achieved in 10 min, and the relative standard deviations (relative standard deviation) of migration times and corrected peak areas were <3% for intra-day assay and <5% for inter-day assay. Limits of detection (LODs) were 0.12-1.70 nM for the eight analytes, which are well below the concentrations expected in real fluids. Compared with previously reported methods, 5 to 600-fold improvements in sensitivity were achieved using LIF detection. Sample preparation and anal. time were short and the derivatives of the analytes were highly stable. The method was fully validated with real plasma and urine and recoveries of spiked compounds were 95-102% with the relative standard deviation <4%. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Computed Properties of C25H15NO9).
2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C25H15NO9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem