Day: February 27, 2023

Dihydrobenzofurans and Propynylthiophenes From the Roots of Eupatorium heterophyllum was written by Hu, Yiming;Saito, Yoshinori;Gong, Xun;Matsuo, Yosuke;Tanaka, Takashi. And the article was included in Natural Product Communications in 2022.Synthetic Route of C8H8O This article mentions the following:

Seven new dihydrobenzofurans and 2 new propynyl thiophenes were isolated from the roots of Eupatorium heterophyllum together with 13 known compounds The compounds were characterized using spectroscopic methods including 2D NMR, IR, and mass spectrometric techniques. Aerial parts of this plant have been known to contain various sesquiterpenoids and displayed high chem. diversity (several compounds isolated and/or identified) among their chem. constituents depending on the collection site. Nevertheless, we found that the chem. diversity in the roots was lower than in the aerial parts. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Synthetic Route of C8H8O).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Synthetic Route of C8H8O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effect of Solvents on Persistent Free Radical Content in the Absence of Reactions was written by Tannous, Joy H.;Tulegenova, Diana;de Klerk, Arno. And the article was included in Energy & Fuels in 2022.SDS of cas: 496-16-2 This article mentions the following:

The impact of a solvent environment on persistent free radical concentrations at ambient conditions was studied by ESR spectrometry. The analyte selected was Canadian oil-sand-derived bitumen due to its high persistent free radical content. The ability of 54 different solvents to produce a homogeneous 5 wt % solution of bitumen was evaluated. The influence of solvents on the free radical content in bitumen was determined exclusively for solvents that were capable of quant. dissolving the bitumen. These were compounds in the classes of alkynes, mono- and bicyclic benzene-derivatives, and heteroatom-containing compounds containing nitrogen, oxygen, sulfur, and chlorine. It was found that a shift in the g-factor of bitumen occurred when the solvent was changed. The shift was attributed to the radical-solvent interaction that is affected by the polarity of the solvent and reflected in the solvent dipole moment property. The change in the free radical concentration was independent of changes in g-factor and was not correlated with any of the following solvent properties: mol. weight, dipole moment, dielec. constant, refractive index, d., and viscosity. There was a relationship between the free radical concentration in bitumen and the ionization potential of sulfur-containing and diarom. hydrocarbon solvents. It was concluded that the bulk liquid properties that affected the electronic environment of the free radical species, resulting in a shift in g-factor, were not related to the bulk liquid properties that affected the dissociation equilibrium and resulted in a change in the free radical concentration In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2SDS of cas: 496-16-2).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.SDS of cas: 496-16-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling was written by Jayasingha, Jayasingha Arachchige Chathuranga Chanaka;Lee, Kyoung Tae;Choi, Yung Hyun;Kang, Chang-Hee;Lee, Mi-Hwa;Kim, Gi-Young. And the article was included in Asian Pacific Journal of Tropical Biomedicine in 2022.Related Products of 1461-15-0 This article mentions the following:

To investigate the effect of an aqueous extract of Protaetia brevitarsis (AEPB) on osteogenesis using preosteoblast MC3T3-E1 cells and zebrafish larvae. Flow cytometric anal. was used to measure the cytotoxicy. Alk. phosphatase activity was detetmined using p-nitrophenyl phosphate as a substrate. Calcium deposition was detected using alizarin red staining along with osteogenic marker expression in preosteoblast MC3T3E1 cells. In addition, vertebral formation in zebrafish larvae was detected using calcein staining and osteogenic gene expression. AEPB highly promoted the expression of osteogenic markers including runt-related transcription factor 2, osterix, and alk. phosphatase, along with elevated levels of mineralization in MC3T3-E1 cells. Moreover, AEPB accelerated vertebral formation in zebrafish larvae accompanied by upregulated expression of osteogenic genes. FH535, an inhibitor of Wnt/β-catenin, suppressed AEPB-induced osteogenic gene expression and vertebral formation, indicating that AEPB stimulates osteogenesis by activating the Wnt/ β-catenin signaling pathway. AEPB stimulates osteoblast differentiation and bone formation by activating β-catenin. Therefore, AEPB is a promising material that induces osteogenesis, and is useful for the treatment of bone resorption diseases. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0Related Products of 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Related Products of 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Thermochromic systems based on complexes of some triarylmethane dyes was written by Raditoiu, Valentin;Raditoiu, Alina;Wagner, Luminita;Amariutei, Viorica;Nicolae, Cristian Andi. And the article was included in Revista de Chimie (Bucharest, Romania) in 2013.Name: Crystal violet lactone This article mentions the following:

The paper presents some triarylmethane dyes and their use in thermochromic systems of donor-accepting type. Compounds are characterized by FT-IR spectra, UV-Vis reflectance spectra and color measurements in CIELAB system and thermal anal. Some considerations are made in relationship with dyestuff structure, developing agent and solvents used to obtain thermochromic systems. The effect of the ratio between the developing agent and lactone dye on the color differences was studied from reflectance spectra and color measurements while the influence of the solvent type on the transition temperature was analyzed using dynamic scanning calorimetry. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Name: Crystal violet lactone).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: Crystal violet lactone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Solar photocatalytical treatment of carbofuran at lab and pilot scale: Effect of classical parameters, evaluation of the toxicity and analysis of organic by-products was written by Lopez-Alvarez, Blady;Torres-Palma, Ricardo A.;Penuela, Gustavo. And the article was included in Journal of Hazardous Materials in 2011.HPLC of Formula: 1563-38-8 This article mentions the following:

The TiO₂ solar-photocatalytical degradation of the pesticide carbofuran (CBF) in water, at laboratory- and pilot-scale, was studied. At laboratory-scale the evaluation of CBF concentration (14-282 μmol/L) showed that the system followed a Langmuir-Hinshelwood kinetics type. TiO₂ concentration (0.05-2 g/L) and initial pH (3-9) were also evaluated and optimized using the surface response methodol. and the Pareto diagram. In the range of variables studied, initial pH 7.60 and 1.43 g/L of TiO₂ favored the efficiency of the process. Under optimal conditions the evolution of substrate, COD, dissolved organic C, toxicity and organics byproducts were evaluated. In the pilot-scale tests, using direct sunlight, 55 mg/L of CBF in a com. formulation was eliminated after 420 min; while after 900 min of treatment 80% of toxicity (1/E₅₀ on Vibrio fischeri), 80% of COD and 60% of dissolved organic C were removed. The anal. and evolution of 5 CBF byproducts, as well the evaluation of the treatment in the presence of isopropanol or using acetonitrile as a solvent suggest that the degradation is mainly carried out by [rad]OH radical attack. A schema depicting the main degradation pathway is proposed. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8HPLC of Formula: 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Investigation of air and soil pollution in the residential areas of the city of Grozny by persistent organic pollutants was written by Shakhtamirov, I. Ya.;Amirova, Z. K.. And the article was included in Ekologiya Urbanizirovannykh Territorii in 2011.Related Products of 205-39-0 This article mentions the following:

The results of studies of contamination by persistent organic pollutants (PAHs, PCBs, organochlorine pesticides), air and soil of the city of Grozny. Studies performed in the monitoring of POPs in Europe within the framework of MONET-CEEC regional center for POPs, Brno, Czech Republic. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Related Products of 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Use of compounds in conjunction with fertilizers was written by Anonymous. And the article was included in Research Disclosure in 1975.Electric Literature of C8H6O2 This article mentions the following:

Compounds of the formula I (where R1 to R4 may be the same or different alkyl groups) are used in conjunction with fast or slow acting fertilizers to retard plant growth. Thus, I (R1 = R2 = R4 = Me; R3 = Et [26225-79-6]) was applied either at the same time or 3-4 weeks subsequent to the application of solid or liquid form fertilizers. When applied as a mixture with a slow-release fertilizer the preferred proportion was 15-60 parts by weight of N and 1-4 parts I. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Electric Literature of C8H6O2).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C8H6O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats was written by Jang, Soo Min;Bae, Soo Hyeon;Choi, Woong-Kee;Park, Jung Bae;Kim, Doyun;Min, Jee Sun;Yoo, Hunseung;Kang, Minseok;Ryu, Keun Ho;Bae, Soo Kyung. And the article was included in Xenobiotica in 2015.HPLC of Formula: 6807-83-6 This article mentions the following:

SKI3301, a standardized dried 50% ethanolic extracts of Sophora tonkinensis, contains four marker compounds (trifolirhizin, TF; (-)-maackiain, Maack; (-)-sophoranone, SPN, and (2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran, ABF), is being developed as an herbal medicine for the treatment of asthma in Korea. This study investigates the pharmacokinetic properties of SKI3301 extract in rats.2. The dose-proportional AUCs suggest linear pharmacokinetics of TF, Maack, SPN and ABF in the SKI3301 extract i.v. dose range of 5-20 mg/kg. After the oral administration of 200-1000 mg/kg of the extract, TF and Maack exhibited non-linearity due to the saturation of gastrointestinal absorption. However, linear pharmacokinetics of SPN and ABF were observed3. The absorptions of TF, Maack, SPN and ABF in the extract were increased relative to those of the resp. pure forms due to the increased solubility and/or the decreased metabolism by other components in the SKI3301 extract4. No accumulation was observed after multiple dosing, and the steady-state pharmacokinetics of TF, Maack, SPN and ABF were not significantly different from those after a single oral administration of the extract5. The pharmacokinetics of TF, SPN and ABF were not significantly different between male and female rats after oral administration of the extract, but a significant gender difference in the pharmacokinetics of Maack in rats was observed6. Our findings may help to comprehensively elucidate the pharmacokinetic characteristics of TF, Maack, SPN and ABF and provide useful information for the clin. application of SKI3301 extract In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6HPLC of Formula: 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase was written by Bagal, Sharan K.;Gregson, Clare;O Donovan, Daniel H.;Pike, Kurt G.;Bloecher, Andrew;Barton, Peter;Borodovsky, Alexandra;Code, Erin;Fillery, Shaun M.;Hsu, Jessie Hao-Ru;Kawatkar, Sameer P.;Li, Chengzhi;Longmire, David;Nai, Youfeng;Nash, Samuel C.;Pike, Andrew;Robinson, James;Read, Jon A.;Rawlins, Phillip B.;Shen, Minhui;Tang, Jia;Wang, Peng;Woods, Haley;Williamson, Beth. And the article was included in Journal of Medicinal Chemistry in 2021.Product Details of 2135600-87-0 This article mentions the following:

In this paper the discovery of potent and orally bioavailable EED ligands with good solubilities was disclosed. The solubility of the EED ligands was optimized through a variety of design tactics, with the resulting compounds exhibiting in vivo efficacy in EZH2-driven tumors. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0Product Details of 2135600-87-0).

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 2135600-87-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid characterization of the chemical constituents of Sijunzi decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry was written by Guan, Zhibo;Wang, Miao;Cai, Yi;Yang, Hongmei;Zhao, Min;Zhao, Chunjie. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2018.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Sijunzi decoction, a renowned Chinese prescription drug, has long been utilized to treat gastrointestinal problems. Ultra-HPLC combined with Fourier transform ion cyclotron resonance MS was used to sep. and characterize the components of Sijunzi decoction. The UHPLC was carried out on a C8 column (150 × 2.1 mm, 1.8 μm); the mobile phase consisted of 0.2% formic acid (A) and acetonitrile (B). Characterization of 120 chem. compounds was performed by UHPLC-MS. The key constituents among them included ginsenosides (in Radix Ginseng), 16 triterpene carboxylic acids (in Poria), sesquiterpenes (in Rhizoma Atractylodis Macrocephalae), triterpene saponins (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) as well as flavonoids (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) in Sijunzi decoction. This research developed the bases for prospective research associated with Sijunzi decoction, together with being expected to be useful to rapidly extract and characterize the constituents in other Traditional Chinese herbal formulations. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem