Tag: 477.0178

A Structure-Activity Investigation on Modified Analogues of an Argininocalixarene Based Non-viral Gene Vector was written by Lomazzi, Michela;Franceschi, Valentina;Bagnacani, Valentina;Vezzoni, Carlo Alberto;Donofrio, Gaetano;Casnati, Alessandro;Sansone, Francesco. And the article was included in European Journal of Organic Chemistry in 2021.Name: (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride This article mentions the following:

The tetra-L-arginino-tetrahexyloxycalix[4]arene 1 has shown extraordinary abilities to compact and internalize different types of Nucleid Acid cargos (DNA, microRNA, PNA) into cells even known to be transfected with great difficulties by com. non-viral gene delivery systems. This activity, accompanied by negligible toxicity, makes this calixarene a rather promising prototype of vector for Gene Therapy. In this study we report how small structural changes like (i) the lower rim alkyl substituents, (ii) the type of the terminal cationic headgroups (guanidinium or primary ammonium), (iii) the length of the linker between the macrocycle and the terminal cationic headgroup, (iv) the presence/absence of the basic α-amino group of Arg, and (v) the stereochem. (L or D) of Arg, might affect the ability of the novel calixarene vectors to compact DNA and to deliver its cargo into the cells. In the experiment, the researchers used many compounds, for example, (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0Name: (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride).

(S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Name: (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates was written by Vernall, Andrea J.;Ballet, Steven;Abell, Andrew D.. And the article was included in Tetrahedron in 2008.Category: benzofurans This article mentions the following:

Olefin tethers of variable length, introduced into a natural amino acid (side-chain of Ser, Cys; N-terminus of Arg; C-terminus of Phe and Tic; and in both the side-chain and either the N- or C-terminus of Ser, Cys and Tyr), undergo metathesis on treatment with Grubbs’ second generation catalyst. Side-chain linked dimers of Ser, Cys and Tyr were obtained by cross-metathesis, while olefin installation at the N- and C-terminus led to dimers of Arg and Phe (or Tic), resp. Ring-closing metathesis of the doubly alkenylated derivatives of Ser, Cys and Tyr gave 12-, 20- and 24-membered macrocycles. In the experiment, the researchers used many compounds, for example, (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0Category: benzofurans).

(S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Deaminative Arylation of Amino Acid-derived Pyridinium Salts was written by Hoerrner, Megan E.;Baker, Kristen M.;Basch, Corey H.;Bampo, Earl M.;Watson, Mary P.. And the article was included in Organic Letters in 2019.Product Details of 257288-19-0 This article mentions the following:

A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines has been developed. Combined with formation of the pyridinium salts from amino acid derivatives, this method enables amino acid derivatives to be efficiently transformed into α-aryl esters and amides. Under the mild conditions, broad functional group tolerance on both the amino acid derivatives and the arylboroxine are observed, including protic functional groups. Mechanistic studies support an alkyl radical intermediate, similar to other cross-couplings of alkylpyridinium salts. In the experiment, the researchers used many compounds, for example, (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0Product Details of 257288-19-0).

(S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 257288-19-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem