Day: February 6, 2023

The convenient use of fluorescamine for spectrofluorimetric determination of midodrine hydrochloride in pure form and its tablets formulation: Application to content uniformity testing was written by Omar, Mahmoud A.;Nagy, Dalia M.;Halim, Monica E.. And the article was included in Luminescence in 2019.HPLC of Formula: 38183-12-9 This article mentions the following:

A novel sensitive and simple spectrofluorimetric method was developed then validated for determination of midodrine in both its authentic pure form and its tablets. This method is based on the reaction between midodrine’s aliphatic primary amine moiety with fluorescamine reagent, using borate buffer at pH 7.8 and yielding a highly fluorescent product whose fluorescence intensity was measured at 462 nm after excitation at 388 nm. This method represents the first attempt for determination of midodrine spectrofluorimetrically. A calibration curve was constructed showing that the linear range was 0.2-3.0 μg/mL. The limit of detection and limit of quantitation values were 0.06 and 0.19 μg/mL resp. The correlation coefficient (r) and the determination coefficient (r²) values were 0.9992 and 0.9984 resp. The proposed method was validated according to ICH guidelines and successfully applied for determination of midodrine in its tablets with an overall % recovery of 99.56 ± 0.95. Finally, the presented method was adapted to study the content uniformity test according to USP guidelines. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A fluorescence turn-on assay for simple and sensitive determination of hemin and blood stains was written by Zhao, Liang;Chen, Fuqian;Huang, Wenyi;Bao, Huayu;Hu, Yingjie;Huang, Xin-an;Deng, Tao;Liu, Fang. And the article was included in Sensors and Actuators, B: Chemical in 2020.SDS of cas: 76-54-0 This article mentions the following:

Hemin, a sort of important Fe(III)-coordinated protoporphyrin IX complexes, plays critical roles in many biol. processes. Besides, hemin and its derivatives have been considered as biochem. markers to distinguish blood against other colored samples. The development of simple and sensitive methods for hemin determination is thus becoming important. In this research, a novel dihydrofluorescein derivative has been synthesized and applied as the fluorescence reporter. Inorganic H₂O₂ and organic tert-Bu hydroperoxide (TBHP), artemisinin (ART) have been used as peroxide sources to generate reactive radical species under hemin catalysis, which subsequently oxidize non fluorescent dihydrofluorescein to its fluorescent form. The limit of detection (LOD) was found down to picomolar levels (64 pM, 350 pM, 420 pM for H₂O₂, TBHP, ART systems resp.). Moreover, a simple detection strip has been prepared by incorporating both ART and fluorescence reporter into the filter papers, which offers a simple strategy to conveniently distinguish blood stains against other colored stains. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0SDS of cas: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.SDS of cas: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The Effect of a Weak Static Magnetic Field in the Range of Magnitudes from a “Zero” Field (0.01μT) to 100μT on the Production of Reactive Oxygen Species in Nonactivated Neutrophils was written by Novikov, V. V.;Yablokova, E. V.;Shaev, I. A.;Fesenko, E. E.. And the article was included in Biophysics (Moscow, Russian Federation) in 2020.Computed Properties of C20H10Cl2O5 This article mentions the following:

Abstract: It was shown that 40-min exposure of peritoneal neutrophils to hypomagnetic conditions (with a residual field of 0.01μT) caused a significant (25%) decrease in the intensity of intracellular dichlorofluorescein fluorescence. This effect of the weak magnetic field persisted if the constant magnetic field was increased to 1μT. Upon further increase of the field to 2.5μT, the effect of the field disappeared and reappeared at 5μT in a reduced form, reaching a maximum at 7μT. There was an equally pronounced and stable inhibitory effect under a sequential increase in the induction of a constant magnetic field (9, 15, and 19.5μT), the degree of manifestation of which was significantly reduced only at 30μT. Fluorescence intensity of the 2,7-dichlorodydrofluorescein oxidation products did not differ from the control values at a constant magnetic field of 45μT. There was no observed effect on these processes under further increase of the field to 74 and 100μT. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability was written by Alhalaweh, Amjad;Alzghoul, Ahmad;Mahlin, Denny;Bergstroem, Christel A. S.. And the article was included in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2015.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Amorphous materials are inherently unstable and tend to crystallize upon storage. In this study, we investigated the extent to which the phys. stability and inherent crystallization tendency of drugs are related to their glass-forming ability (GFA), the glass transition temperature (T_g) and thermodn. factors. Differential scanning calorimetry was used to produce the amorphous state of 52 drugs [18 compounds crystallized upon heating (Class II) and 34 remained in the amorphous state (Class III)] and to perform in situ storage for the amorphous material for 12 h at temperatures 20 °C above or below the T_g. A computational model based on the support vector machine (SVM) algorithm was developed to predict the structure-property relationships. All drugs maintained their Class when stored at 20 °C below the T_g. Fourteen of the Class II compounds crystallized when stored above the T_g whereas all except one of the Class III compounds remained amorphous. These results were only related to the glass-forming ability and no relationship to e.g. thermodn. factors was found. The exptl. data were used for computational modeling and a classification model was developed that correctly predicted the phys. stability above the T_g. The use of a large dataset revealed that mol. features related to aromaticity and π-π interactions reduce the inherent phys. stability of amorphous drugs. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential was written by Czerwonka, Arkadiusz;Lemieszek, Marta K.;Karpinska, Monika;Matysiak, Joanna;Niewiadomy, Andrzej;Rzeski, Wojciech. And the article was included in Medicinal Chemistry Research in 2018.Reference of 54802-10-7 This article mentions the following:

In this paper, we present the biol. effect of the newly synthesized 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one (DPBT) on human colon adenocarcinoma cell lines (HT-29 and LS180). Addnl., DPBT cytotoxicity was examined in human colon epithelial cells (CCD 841 CoTr) and human skin fibroblasts (HSF). The studies revealed a significant decrease in the proliferation of cancer cells after exposure to DPBT at concentrations in the range of 10-100 μM. Addnl., DPBT was not toxic to normal CCD 841 CoTr and HSF cells at concentrations that induced inhibition of cancer cell proliferation. The nature of the anti-proliferative action of DPBT in the cell cycle progression in colon cancer cells and the expression of proteins involved in this process were examined by flow cytometry and western blotting, resp. The investigations demonstrated higher sensitivity of LS180 than HT-29 to the DPBT treatment. The anti-proliferative action of DPBT in LS180 was attributed to cell cycle arrest in the G₁ phase via up-regulation of p27^KIP1 and down-regulation of cyclin D1 and CDK4 proteins. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Reference of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photoluminescence and infrared absorption spectra of aminated nanocrystalline diamond surface was written by Remes, Z.;Kozak, H.;Babchenko, O.;Ukraintsev, E.;Kromka, A.. And the article was included in Advanced Science, Engineering and Medicine in 2013.Computed Properties of C17H10O4 This article mentions the following:

The com. available protected gold on glass mirrors are coated by the nanocrystalline diamond (NCD) layers using the microwave based surface wave-discharge in linear antenna chem. vapor deposition (CVD) process. To demonstrate the high sensitivity of these mirrors for the surface characterization, the oxidized NCD surface is grafted by the wet amino-organosilane treatment. AFM reveals that the macroscopically homogeneous amino-organosilane coverage consists of the insulated microscopic organosilane clusters with submicron height. The presence of the amino groups on the NCD surface was tested by the photoluminescence spectroscopy in blue-green spectral region using fluorescamine reagent under UV excitation. The grazing angle reflectance Fourier transform IR (GAR FTIR) spectroscopy in the mid IR region detects with high sensitivity the characteristic mol. vibrations of the functional groups. From the signal to noise ratio follows that the GAR FTIR is a potentially suitable method for monolayer detection on surface-enhanced nanostructures. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges was written by Chen, Kai;Zhao, Li;Sun, Jie;Gu, Xuenan;Huang, Chenyang;Su, Haoran;Fan, Yubo. And the article was included in Science China Materials in 2022.Reference of 76-54-0 This article mentions the following:

Guided bone regeneration (GBR) is a therapeutic procedure used to enhance alveolar bone volume before dental implants. Com. non-absorbable membranes (i.e., titanium membranes) typically require a second surgery to remove, whereas absorbable membranes (i.e., collagen membranes) will fail when put over extensive bone lesions due to their low mech. strength. The GBR membrane that has been sought is still being developed. Biodegradable metals (BMs), particularly Mg and Zn, have recently been postulated as promising barrier membrane candidates. Herein, the goal of this research is to evaluate the mech. and biol. feasibility of using BMs as GBR membranes. It shows that BMs have a wide range of potential applications as GBR membranes, owing to their benign biocompatibility, sufficient mech. support, tunable degradation rate, good osteogenic capabilities, broad-spectrum antibacterial behavior, and improved wound healing ability. The rapid degradation rate, hydrogen evolution impact, and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes, which can be improved by surface modifications, heat treatment, alloying, etc. Due to its acceptable degradation rate and lack of gas production, Zn appears to be a better candidate for usage as a GBR membrane. In general, advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clin. trials. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators was written by Jumppanen, Mikael;Kinnunen, Sini M.;Valimaki, Mika J.;Talman, Virpi;Auno, Samuli;Bruun, Tanja;Boije af Gennas, Gustav;Xhaard, Henri;Aumuller, Ingo B.;Ruskoaho, Heikki;Yli-Kauhaluoma, Jari. And the article was included in Journal of Medicinal Chemistry in 2019.Reference of 54802-10-7 This article mentions the following:

Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4-NKX2-5 transcriptional synergy. Here, the chem. space around the mol. structure of 1 was explored by synthesizing and characterizing 220 derivatives and structurally related compounds In addition to the synergistic transcriptional activation, selected compounds were evaluated for their effects on transcriptional activities of GATA4 and NKX2-5 individually as well as potential cytotoxicity. The structure-activity relationship (SAR) anal. revealed that the aromatic isoxazole substituent in the southern part regulates the inhibition of GATA4-NKX2-5 transcriptional synergy. Moreover, inhibition of GATA4 transcriptional activity correlated with the reduced cell viability. In summary, comprehensive SAR anal. accompanied by data anal. successfully identified potent and selective inhibitors of GATA4-NKX2-5 transcriptional synergy and revealed structural features important for it. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Reference of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Reference of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation and reactions of a benzofurylmercuric compound was written by Izumi, Taeko;Takeda, Toru;Kasahara, Akira. And the article was included in Yamagata Daigaku Kiyo, Kogaku in 1974.Synthetic Route of C10H8O3 This article mentions the following:

2-Benzofurylmercuric chloride (I) was obtained by the reaction of benzofuran (II), 1 equivalent HgCl2, and 2 equivalentsNaOAc. 3H2O in aqueous EtOH at room temperature 5 days; m.p. 274-8°. I was also prepared by the reaction of Na coumarylate with an equivalent amount of HgCl2 in 1 l. water followed by decarboxylation under gentle reflux. Benzofurylation of olefins such as styrene, Et acrylate, Et crotonate, and H2C:CHCN were performed in the presence of Li2PdCl4 in MeOH or MeCN, accompanied by the formation of 2,2′-dibenzofuran (III). Carbonylation of I at 100° 6 hr under 50 atm CO pressure in the presence of Li2PdCl4 in MeOH gave Me coumarylate, 2,2′-dibenzofuryl ketone, and a small amount of III. 2-Acetylation and benzoylation of I with acyl chlorides, coupling reaction to 2,2′-dibenzofurylmercury by Na2S2O3, and 2-bromination with Br were reported. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aggregation-induced emission nanoparticles with NIR and photosensitizing characteristics for resistant bacteria elimination and real-time tracking was written by Yuan, Huanxiang;Li, Zelin;Bai, Haotian;Chen, Zhuo;Yao, Chuang;Jia, Shaochuan;Li, Li;Qi, Ruilian;Zhao, Cui-Hua. And the article was included in Materials Chemistry Frontiers in 2021.Reference of 76-54-0 This article mentions the following:

Because of the steady increase in multi-drug-resistant bacterial infections, we developed a viable treatment strategy using new antibacterial nanomaterials with photosensitizing effects. In this work, three triphenylamine derivates (TPA-2PE, TPA-PCN, and TPA-2PCN) and amphiphilic polystyrene maleic anhydride (PSMA) were used to successfully prepare three corresponding nanoparticles. Compared to TPA-2PE, the introduced cyano unit resulted in a red shift for TPA-PCN and TPA-2PCN with near-IR (NIR) emission. The specific aggregation-induced emission (AIE) characteristic contributed to the retentive photophys. property and the increased fluorescence quantum yield (QY) of these luminous mols. in nanoparticles. Our in vitro study indicated that the nanoparticles were able to tightly bind to the surface of bacteria by hydrogen bond interaction, and their bacterial toxicity was successfully directed against antibiotic-resistant Escherichia coli. The bactericidal performance was further amplified under white light irradiation by the supplied photosensitizing effect. Addnl., the killed bacteria were stained with the nanoparticles and subsequently emitted NIR emission, regardless of the interference of bacterial autofluorescence. The sterilization effects of the nanoparticles were tracked in situ and qual. characterized by the NIR self-reporting function. In the protocol reported herein, we describe all the essential factors for addressing antibiotic resistance, and therefore, this work includes all the necessary criteria for designing addnl. antibacterial nanomaterials in the future. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem