Aggregation-induced emission nanoparticles with NIR and photosensitizing characteristics for resistant bacteria elimination and real-time tracking was written by Yuan, Huanxiang;Li, Zelin;Bai, Haotian;Chen, Zhuo;Yao, Chuang;Jia, Shaochuan;Li, Li;Qi, Ruilian;Zhao, Cui-Hua. And the article was included in Materials Chemistry Frontiers in 2021.Reference of 76-54-0 This article mentions the following:
Because of the steady increase in multi-drug-resistant bacterial infections, we developed a viable treatment strategy using new antibacterial nanomaterials with photosensitizing effects. In this work, three triphenylamine derivates (TPA-2PE, TPA-PCN, and TPA-2PCN) and amphiphilic polystyrene maleic anhydride (PSMA) were used to successfully prepare three corresponding nanoparticles. Compared to TPA-2PE, the introduced cyano unit resulted in a red shift for TPA-PCN and TPA-2PCN with near-IR (NIR) emission. The specific aggregation-induced emission (AIE) characteristic contributed to the retentive photophys. property and the increased fluorescence quantum yield (QY) of these luminous mols. in nanoparticles. Our in vitro study indicated that the nanoparticles were able to tightly bind to the surface of bacteria by hydrogen bond interaction, and their bacterial toxicity was successfully directed against antibiotic-resistant Escherichia coli. The bactericidal performance was further amplified under white light irradiation by the supplied photosensitizing effect. Addnl., the killed bacteria were stained with the nanoparticles and subsequently emitted NIR emission, regardless of the interference of bacterial autofluorescence. The sterilization effects of the nanoparticles were tracked in situ and qual. characterized by the NIR self-reporting function. In the protocol reported herein, we describe all the essential factors for addressing antibiotic resistance, and therefore, this work includes all the necessary criteria for designing addnl. antibacterial nanomaterials in the future. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).
2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 76-54-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem