Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges was written by Chen, Kai;Zhao, Li;Sun, Jie;Gu, Xuenan;Huang, Chenyang;Su, Haoran;Fan, Yubo. And the article was included in Science China Materials in 2022.Reference of 76-54-0 This article mentions the following:
Guided bone regeneration (GBR) is a therapeutic procedure used to enhance alveolar bone volume before dental implants. Com. non-absorbable membranes (i.e., titanium membranes) typically require a second surgery to remove, whereas absorbable membranes (i.e., collagen membranes) will fail when put over extensive bone lesions due to their low mech. strength. The GBR membrane that has been sought is still being developed. Biodegradable metals (BMs), particularly Mg and Zn, have recently been postulated as promising barrier membrane candidates. Herein, the goal of this research is to evaluate the mech. and biol. feasibility of using BMs as GBR membranes. It shows that BMs have a wide range of potential applications as GBR membranes, owing to their benign biocompatibility, sufficient mech. support, tunable degradation rate, good osteogenic capabilities, broad-spectrum antibacterial behavior, and improved wound healing ability. The rapid degradation rate, hydrogen evolution impact, and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes, which can be improved by surface modifications, heat treatment, alloying, etc. Due to its acceptable degradation rate and lack of gas production, Zn appears to be a better candidate for usage as a GBR membrane. In general, advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clin. trials. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).
2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 76-54-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem