Heterocyclic Building Block-benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

General procedure: The target thiosemicarbazones were prepared by dissolving corresponding ketone (2a-b) (0.005 mol) and appropriate thiosemicarbazide (1a-q) (0.005 mol) in ethanol containing 1-2 drops of HCl as catalyst. The reaction mixture was heated under reflux at 80 C for 2-3 h and course of the reaction was monitored by TLC. After the reaction completion,the excess solvent was evaporated under vacuum and the crystalline or amorphous product formed was filtered, washed with hot ethanol and then with diethyl ether to afford the required thiosemicarbazones (3a-u) in excellent yields. The synthesized thiosemicarbazones were further recrystallized by mixture of chloroform-ethanol (1:1). For X-ray measurements, single crystal of 3m was mounted on a MiTeGen loop with grease and examined on a Bruker D8 Venture APEX diffractometer equipped with Photon 100 CCD area detector and Oxford Cryostream cooler at 296 (2) K using graphite-monochromated Mo-Kalpharadiation (lambda=0.71073 A). Data was collected using the APEX-II software [33], integrated using SAINT [34] and corrected for absorption using a multi-scan approach (SADABS) [35]. The structure was solved using intrinsic phasing (SHELXT) [36]. Final cell constants were determined from full least squares refinement of all observed reflections. All non-H atoms were located in subsequent difference maps and refined anisotropically with SHELXL-97 [37], using full least squares refinement against F2. H-atoms were added at calculated positions and refined with a riding model. The structure has been deposited with the CCDC (CSD deposition numbers 1874544).

The synthetic route of 90843-31-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Islam, Muhammad; Khan, Ajmal; Shehzad, Muhammad Tariq; Hameed, Abdul; Ahmed, Nadeem; Halim, Sobia Ahsan; Khiat, Mohammed; Anwar, Muhammad Usman; Hussain, Javid; Csuk, Rene; Shafiq, Zahid; Al-Harrasi, Ahmed; Bioorganic Chemistry; vol. 87; (2019); p. 155 – 162;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

35700-40-4, 2,3-Dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 2,3-dihydro-benzofiran-7-carboxylic acid, (TCI, 20.0 g, 121.8 mmol) in 600 mL of dry acetonitrile was cooled to 0 0C and treated with N,O-dirnethylhydroxylamine hydrochloride (14.25 g, 146.1 mmol). The reaction was allowed to stirfor 10 minutes and EDCI (24.6 g, 158.3 mmol) was added, followed by HOBT (3.2 g, 24.2 mmol) and the resulting mixture was allowed to stirfor 5 minutes. Triethylamine (365.4 mmol) was then added and the reaction mixture was allowed to stirfor 18 hours at room temperature, then diluted with aqueous IN HCl (250 mL) and extracted with ethyl acetate (1.0 L). The organic layer was sequentially washed with aqueous 10% potassium carbonate (200 mL), aqueous IN HCl (200 mL), and brine (200 mL). The organic layer was then dried over magnesium sulfate, filtered and concentrated in vacuo to provide compound 2A (23.37 g, 93 %) as a colorless oil. M.S. found for CnHnNO3: 230.1 1 (M^Na)+.

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; WO2009/152200; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28281-76-7,5-Methoxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A mixture of 4-methoxyphthalic anhydride (27.8 g, 0.16 mol) and formamide (175 ml) was stirred and held at 21O0C for 5 hours and was then allowed to cool to room temperature overnight. The solid material was filtered off, washed sequentially with water (100 ml), 50% aqueous acetone (50 ml) and diethyl ether (200 ml) and sucked dry under reduced pressure to afford A- methoxyphthalimide (21.3 g, 77%) as a pale yellow solid. 1H NMR (DMSOd6) 11.15 (1 H, br s), 7.74 (1 H, d), 7.33-7.28 (2H, m), 3.92 (3H, s).

As the paragraph descriping shows that 28281-76-7 is playing an increasingly important role.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; WO2008/44041; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem