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The reaction of n-BuLi with phthalic anhydride derivatives leads to (Z)-3-butylidenephthalide derivatives.

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Oxy-diphthalic anhydrides are prepared by reacting a halophthalic anhydride with an hydroxyphthalic anhydride in a polar aprotic solvent and in the presence of an alkali metal compound such as KF, CsF or K2 CO3.

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Chemistry is traditionally divided into organic and inorganic chemistry. category: benzofuran, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 27550-59-0

Two series of poly(ester imide)s derived from bis(trimellitic acid anhydride) phenyl ester (TAHQ) and bis[(3,4-dicarboxylic anhydride) phenyl] terephthalate (PAHP), as well as poly(ether imide)s based on hydroquinone diphthalic anhydride (HQDPA), were synthesized with aromatic diamines via solution polycondensation. These polyimide films were transparent with an ultraviolet-visible absorption cut-off wavelength below 375 nm, and with tensile strengths of 42.0-83.8 MPa, tensile moduli of 2.5-4.7 GPa and elongations at break of 2.1-5.4%. Compared with the poly(ether imide)s, the poly(ester imide)s showed higher glass transition temperatures (Tg), lower water absorption (WA) and lower temperature of 5% weight loss (Td5%). Moreover, the poly(ester imide)s derived from PAHP with a low electron affinity of 2.04 eV by theoretical calculation achieved better transparency, lower WA and slightly lower Tg than the corresponding TAHQ-based poly(ester imide)s.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2161O – PubChem

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The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2134O – PubChem

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The first asymmetric synthesis of (S)- and (R)-5-hydroxythalidomides, one of thalidomide’s major metabolites, was achieved using HMDS/ZnBr2-induced imidation as a key reaction. 5-Hydroxythalidomide was found to be configurationally more stable than thalidomide at physiological pH. Stereochemical biological effects of thalidomide and 5-hydroxythalidomide on anti-angiogenesis and antitumor activities were also investigated using racemic and pure enantiomers.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2160O – PubChem

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H4O4. Introducing a new discovery about 27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione

An attempt was made to estimate the dihedral angles phi, psi, omega1 and omega2, of bis(4-hydroxyphthalimide)s (BHPI) and bis-(phenylphthalimides)s (BPI) having diphenyl ether or benzophenone linkages at the center of molecules using solid-state 13C CP/MAS NMR and ab initio nuclear shielding calculations. The TOSS and TOSS & DD pulse sequences were performed in the NMR measurements to obtain exact chemical shifts of each carbon. Total energies were calculated using the B3LYP/6-31G(d) level of theory, and shielding constants were calculated using the RHF/6-31G(d) level of theory for diphenyl ether and benzophenone by varying the angles of phi, psi from 0 to 180 at intervals of 10. The comparison of nuclear shielding calculations between RHF/6-31G(d) and B3LYP/6-311 +G(2d,p) levels of theory indicates that RHF/6-31G(d) has sufficient reliability for calculating shielding constants of diphenyl structures. Since the nuclear shieldings are displaced depending on the dihedral angles, the dihedral angles of BHPIs and BPIs can be estimated by comparing the experimental chemical shifts with the calculated shielding constants. The BHPIs, BPIs and a related polyimide ODPA/ODA were estimated to have symmetric conformations having identical phi and psi and identical omega1 and omega2.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2141O – PubChem

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27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, belongs to benzofurans compound, is a common compound. HPLC of Formula: C8H4O4In an article, once mentioned the new application about 27550-59-0.

Novel thalidomide-deoxyribonucleoside chimeras have been synthesized as potentially safe, thalidomide-based antitumour agents. Copyright

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Benzofuran – Wikipedia,
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Dental material which contains a polymerizable phthalic acid derivative of the general Formula I: with R1?H, methyl or a C1-C5 alkyl residue; R2?H, a phenyl, benzyl or C1-C8 alkyl residue; Q1=is absent or is a C1-C15 alkylene residue, wherein the carbon chain can be interrupted by O or S; Q2=is absent or a (n+1)-valent aliphatic C1-C20 residue, wherein the carbon chain can be interrupted by O or S and wherein Q1 and Q2 cannot be absent simultaneously; X=is absent, is O, S or (?CO?NR4?)?, wherein R4 is H, CH3 or C2H5; Y=is absent, is O, S or (?CO?NR5?)?, wherein R5 is H, CH3 or C2H5; n, m=independently of one another in each case mean 1, 2 or 3; R3?H, CH3, C2H5, Cl, Br or OCH3, and wherein the two carboxyl groups of the benzene ring can together form an anhydride group.

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Benzofuran – Wikipedia,
Benzofuran | C8H2131O – PubChem

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[A] a polyimide, a polyamide, a polyester, a polyamide imide, polyester imide, polyimide resin such as isocyanurate skeleton of various materials, such as modifiers useful as a raw material, a phosphorus atom or a silicon atom or an acid anhydride group 2. (1) An aromatic acid dianhydride represented by the general formula [a] poly. [In the formula, R is, straight or branched alkyl groups such as 1 – 6 carbon atoms, X is, the phosphorus atom or silicon atom, Y is, straight or branched alkyl group such as 1 – 10 carbon atoms, the number of 0 – 3 l, n is 1 or 2, are shown. However, if X is a phosphorus atom, Z is an oxygen atom is n 1, X in the case of the silicon atom, Z is n is 2 is omitted. ][Drawing] no (by machine translation)

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Benzofuran – Wikipedia,
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Objectives The purpose of this work was to study the chemical stability of the new antitumoral beta-lapachone (betaLAP) to determine the degradation pathway/s of the molecule and the degradation kinetics in addition to identifying several degradation products. Method Samples of betaLAP in solution were stored under conditions of darkness and illumination at 40C at which the pseudo-first order rate constants for the betaLAP degradation were determined. Furthermore, drug degraded solutions were concentrated and purified using Sephadex LH-20 and preparative thin-layer chromatography and degradation products were identified by nuclear magnetic resonance spectroscopy. Key findings The results revealed that betaLAP shows two different degradation routes: hydrolysis in the dark and photolysis under the light. The betaLAP exposure to light accelerated the drug degradation about 140 fold, compared with the samples stored in the absence of light. The hydrolysis produced hydroxylapachol as the main degradation product. The photolysis yielded phthalic acid, 6-hydroxy-3methylene-3H-isobenzofuran-1-one and a benzomacrolactone together with a complex mixture of other phthalate-derivatives such as 2-(2-carboxy-acetyl)-benzoic acid. Conclusions This study provides useful information for the development of betaLAP dosage forms, their storage, manipulation and quality control.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2144O – PubChem