Category: 27550-59-0

27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, belongs to benzofurans compound, is a common compound. Product Details of 27550-59-0In an article, once mentioned the new application about 27550-59-0.

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[omega-[N-alkyl-N-(omega-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quantitative study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity.

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Benzofuran | C8H2148O – PubChem

Electric Literature of 27550-59-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione,introducing its new discovery.

The present invention provides compounds, compositions thereof, and methods of using the same.

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Benzofuran – Wikipedia,
Benzofuran | C8H2136O – PubChem

Reference of 27550-59-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, molecular formula is C8H4O4. In a Article，once mentioned of 27550-59-0

A variety of omega-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2157O – PubChem

Synthetic Route of 27550-59-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, molecular formula is C8H4O4. In a article，once mentioned of 27550-59-0

The present invention provides a 4 – hydroxy benzoic anhydride preparation method, using sodium nitrite, sulfuric acid under, the hydrolysis reaction, a step can be from 4 – amino phthalic acid to obtain 4 – hydroxy phthalic acid, finally the 4 – hydroxy phthalic acid vacuum sublimation to obtain 4 – hydroxy benzoic anhydride, the reaction yield of 82% or more. The method of the invention 4 – hydroxy phthalic acid extraction rate is high, hydrolysis process more stable, few by-products, reduces the difficulty and costs of the follow-up purification. In the preparation of all raw materials in the flow, at the same time the reaction process is simple, does not need complicated reaction equipment and stringent reaction conditions. (by machine translation)

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Benzofuran – Wikipedia,
Benzofuran | C8H2140O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 27550-59-0, name is 5-Hydroxyisobenzofuran-1,3-dione, introducing its new discovery. name: 5-Hydroxyisobenzofuran-1,3-dione

The modification of 3?-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3- dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with optimized potency and superior druglike properties. These analogues are more potent than 1 in vitro and are highly selective for mGluR2 vs other mGluR subtypes. They have significantly improved pharmacokinetic (PK) properties, with excellent oral bioavailability and brain penetration. The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2145O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 27550-59-0, name is 5-Hydroxyisobenzofuran-1,3-dione, introducing its new discovery. Computed Properties of C8H4O4

The kinetics and mechanism of the formation of phthalate mono-esters and phthalate di-esters from phthalic anhydride and a variety of mono- and di-hydric alcohols are reported and discussed. The kinetic work is extended to a mechanistic study of the same reactions using titanium tetra-n-butoxide and tri-n-butyltin ethoxide as catalysts. The results support a mechanism involving alkoxy ligand exchange at the metal as a crucial step in the catalysis.

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Benzofuran – Wikipedia,
Benzofuran | C8H2147O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C8H4O4. Introducing a new discovery about 27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione

Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/ or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H4O4, you can also check out more blogs about27550-59-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2129O – PubChem

27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, belongs to benzofurans compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 27550-59-0.

Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-gamma (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells. Based on a SAR (Structure-activity relationships) study and in silico analysis of paecilocin A-mimetic derivatives, additional N-substituted phthalimide derivatives were synthesized and evaluated for PPAR-gammaagonistic activity in both murine liver Ac2F cells and in human liver HepG2 cells by luciferase assay, and for adipogenic activity in 3T3-L1 cells. Docking simulation indicated PD6 was likely to bind most strongly to the ligand binding domain of PPAR-gamma by establishing crucial H-bonds with key amino acid residues. However, in in vitro assays, PD1 and PD2 consistently displayed significant PPAR-activation in Ac2F and HepG2 cells, and adipogenic activity in 3T3-L1 preadipocytes.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2146O – PubChem

Electric Literature of 27550-59-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, molecular formula is C8H4O4. In a Article，once mentioned of 27550-59-0

A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted to the desired aryl fluorides with high regioselectivity. Analysis of the solid-state structures of several Pd(II) complexes, as well as density functional theory (DFT) calculations, shed light on the origin of the enhanced reactivity observed with L1.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 27550-59-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2153O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 5-Hydroxyisobenzofuran-1,3-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, molecular formula is C8H4O4

We have developed a series of thalidomide-derived phthalimide-type estrogen receptor (ER) modulators with characteristic subtype (ERalpha/ERbeta) selectivity, and investigated their structure-activity relationship for ER agonistic and antagonistic activities.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 5-Hydroxyisobenzofuran-1,3-dione, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 27550-59-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2152O – PubChem