Downstream synthetic route of 16859-59-9

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Carboxybenzaldehyde (16, 10.00 g, 66.61 mmol) and ferric chloride (0.030 g, 0.185 mmol) were diluted with thionyl chloride (25 mL) and the mixture was heated at reflux for 1 h. The reaction mixture was allowed to cool to room temperature and concentrated to provide a brown oil. The oil was diluted with hexanes (20 mL) and concentrated to provide a brown solid. The solid was extracted with boiling hexanes (5 x 50 mL), and concentration of the extract provided a white solid (10.96 g, 98percent): mp 52-56 0C (Sloan, et al., 1983; mp 57-59 0C). 1H NMR (300 MHz, CDCl3) delta 7.95-7.93 (m, 1 H), 7.82 (t, J= 7.4 Hz, 1 H), 7.68-7.60 (m, 2 H), 7.10 (s, 1 H).

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; PURDUE RESEARCH FOUNDATION; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH & HUMAN SERVICES; WO2009/140467; (2009); A1;,
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Some tips on 77095-51-3

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Benzofuran-6-carboxylic acid (VI) (50 gms , 0.3086 moles) was suspended in 250 ml MDC and cooled to l5-20C. 5 ml DMF was added at l5-20C followed by thionyl Chloride ( 34 ml , 0.4629 moles). The temperature was raised to 35-40C and the reaction mixture was further stirred for 2 hours. The solvent was removed under vacuum at 45C. The residue was stirred in 250 ml MDC and the solution was cooled to 5-l0C. The solution of 5,7-dichloro-l,2,3,4-tetrahydroisoquinoline- 6-carboxylic acid HC1 (V) ( 74.12 gms , 0.2623 moles) and tri ethyl amine ( 215 ml , 1.5432 moles) in 500 ml MDC , was cooled to 5-l0C. To this solution was added benzofuran-6-carboxylic chloride (VII) maintaining temperature at 5-l0C. The temperature was raised to 25-30C and the reaction mixture was further stirred for 2 hours. The reaction mixture was quenched in 500 ml of water. The organic layer was separated, washed with water and stirred with 2.5 gms of charcoal for 30 minutes. The reaction mixture was filtered over hyflo and the clear filtrate evaporated under vacuum at 40-45C. The residue was stirred in 250 ml ethyl acetate and stirred for an hour at 25-30C. The solid was isolated by filtration and dried to yield titled compound. Yield: 95-98%

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

Reference£º
Patent; CIPLA LIMITED; PHULL, Manjinder Singh; RAO, Dharmaraj Ramachandra; MALHOTRA, Geena; THOPPIL, Sanoj Jose; PAWAR, Sunil Akaram; (28 pag.)WO2019/97547; (2019); A1;,
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Analyzing the synthesis route of 10242-10-1

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Synthesis Example 69 (0667) (5-Chloro-benzofuran-2-yl)methanol (0668) To a tetrahydrofuran solution (12 mL) of 5-chlorobenzofuran-2-carboxylic acid (620 mg, 3.15 mmol), borane-tetrahydrofuran complex (7.88 mL, 7.88 mmol, tetrahydrofuran solution) was added at 0 C. and the resultant solution was stirred at room temperature for 3 hours, at 60 C. for 1 day, and at room temperature for 1 day. After completion of the reaction, concentration under reduced pressure was carried out three times with adding methanol to the reaction solution and the concentrated solution was purified by silica gel column chromatography (hexane/ethyl acetate=3/1?1/1 (v/v)) to obtain the title compound (268 mg, yield 47%).

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; Saito, Noriko; Egi, Jun; Nagai, Hiroshi; Ueno, Megumi; Shintani, Yusuke; Inaba, Yusuke; Adachi, Michiaki; Hirai, Yuichi; Kawazu, Takeshi; Yasutake, Koichi; Takahashi, Daiki; (220 pag.)US9403798; (2016); B2;,
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New learning discoveries about 201809-69-0

201809-69-0, As the paragraph descriping shows that 201809-69-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.201809-69-0,6-Bromobenzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

[A] (rac)-6-Bromo-2,3-dihydro-benzofuran-3-ol To a solution of 6-bromo-benzofuran-3-one (10.5 g, 49.28 mmol) in methanol (100 ml) was added NaBH4 (2.37 g, 64.07 mmol) at 0 C. The reaction mixture was then stirred for 2 hours at room temperature. It was subsequently quenched with saturated ammonium chloride solution (50 ml) and extracted twice with ethyl acetate (2*50 ml). The combined organic phases were dried over Na2SO4 and evaporated under reduced pressure to give 9.75 g (92%) of the title compound as colorless liquid.

201809-69-0, As the paragraph descriping shows that 201809-69-0 is playing an increasingly important role.

Reference£º
Patent; Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan; US2013/18055; (2013); A1;,
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New learning discoveries about 81742-10-1

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, General procedure: Place 5 mL concentrated H2SO4 in a 50 mL round bottom flask and cool in an ice/water bath. Compound 20 (300 mg, 0.5 mmol) is added in portions, and the reaction mixture is stirred at room temperature until TLC shows complete consumption of compound 20. The mixture is added to the stirring Et2O solution (400 mL) at 0 C. The resulting precipitate is filtered, washed with EtOAc, and dried. The crude product is purified by RP-HPLC using TEAA/ACN give compound 5a (96 mg, 20%) and compound 5b (101 mg, 21%).

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ying, Laiqiang; (22 pag.)US10513610; (2019); B1;,
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Some tips on 59434-19-4

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

To a stirred mixture of 4-(trifluoromethyl)benzaldehyde (2.8 g, 16.1 mmol) and anhydrous Magnesium sulfate (16 g, 134 mmol) in anhydrous acetonitrile (200 mL) was added 4-aminoisobenzofuran-1(3H)-one (2 g, 13.4 mmol) at room temperature. After the addition, the mixture was stirred at reflux for overnight. The mixture was filtered and the cake was washed with ethyl acetate (50 mL¡Á3). The filtrate was concentrated to give crude product. The crude product was washed with petroleum ether and re-crystallized from ethyl acetate to give the title compound (2.8 g, yield: 68%). LC-MS (ESI) m/z: 306 (M+1)+

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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New learning discoveries about 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of aniline (0.690 g, 7.41 mmol) in dichloromethane (25 mL), 3-methylbenzofuran-2-carboxylic acid (1c) (1.00 g, 5.7 mmol) was added with stirring. Then DMAP (0.116 g, 0.57 mmol) was added, followed by DCC (1.220 g, 5.9 mmol). The reaction was left to stir at room temperature for 23 h. The reaction mixture was then filtered and the filtrate washed with water (20 mL * 2), then 5% acetic acid (20 mL * 2) and again with water (20 mL * 2). The crude product was recrystallized from methanol to yield 2c as off-white crystals (0.896 g, 63%), mp 118-120 C. 1H NMR (300 MHz, CDCl3) delta 2.68 (s, 3H), 7.13-7.18 (t, J = 7.4 Hz, 1H), 7.30-7.52 (m, 5H), 7.62-7.65 (d, J = 7.57 Hz, 1H) 7.72-7.73 (d, J = 8.57 Hz, 2H), 8.35 (s, 1H). 13C NMR (300 MHz, CDCl3) delta 9.1, 111.6, 120.0, 121.1, 123.4, 123.9, 124.6, 127.5, 129.2, 129.9, 137.5, 142.4, 153.3, 158.1. MS(ESI)+ calcd for C16H14NO2 [M+H]+: 252.1025, found: 252.1027., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Article; Marriott, Karla-Sue C.; Morrison, Andrew Z.; Moore, Misty; Olubajo, Olarongbe; Stewart, Leonard E.; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6856 – 6861;,
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New learning discoveries about 41019-56-1

41019-56-1, 41019-56-1 Methyl benzofuran-4-carboxylate 22326486, abenzofuran compound, is more and more widely used in various.

41019-56-1, Methyl benzofuran-4-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of LiOH (1.44 g, 34.3 mmol) in water (20 mL) wasadded to a solution of the above ester (2.02 g, 11.4 mmol) in THF(20 mL) and MeOH (20 mL) and the solution was stirred at 20 Cfor 16 h and then evaporated. The residue was dissolved in water(50 mL) and acidified with conc. HCl and the precipitate was filteredand dried to give benzofuran-4-carboxylic acid (1.83 g,99%). 1H NMR (DMSO d6) d 13.10 (s, 1H), 8.14 (d, J = 2.1 Hz, 1H),7.85-7.91 (m, 2H), 7.43 (t, J = 7.9 Hz, 1H), 7.33 (dd, J = 2.1, 1.0 Hz,1H). Found: [MH] = 161.1.

41019-56-1, 41019-56-1 Methyl benzofuran-4-carboxylate 22326486, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1797 – 1809;,
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Analyzing the synthesis route of 58546-89-7

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

58546-89-7, A solution of Alloc-THP protected PBD-Py acid 14a (150 mg, 0.23 mmol, 1.0 equivalent) was dissolved in DMF. EDCI (0.46 mmol, 2.0 eq) and DMAP (0.58 mmol, 2.5 eq) were added to the stirred solution of 14a at room temperature and the mixture was allowed to stir for 30 minutes after which the benzofuran-5-amine (38.3 mg, 0.29 mmol, 1.25 eq) was added. The reaction mixture was allowed to stir for a further 3 hour at which point TLC showed completion of reaction. The reaction was quenched by pouring it onto a mixture of ice/water mixture and the resulting mixture was extracted with ethyl acetate (3 x 150 mL). The combined extracts were sequentially washed with citric acid (50 mL), saturated aqueous NaHC03 (50 mL), water (50 mL), brine (50 mL) and finally dried over MgS04. Excess ethyl acetate was evaporated by rotary evaporator under reduced pressure and the crude product was directly used in the next step without further purification. m/z (+EI) calc. for C4oH45N5010 (M)+ 755.91 found 756.76 ([M+H]+

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

Reference£º
Patent; UCL BUSINESS PLC; SPIROGEN SARL; HOWARD, Philip Wilson; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; TAYLOR, Peter William; WO2013/164592; (2013); A1;,
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Downstream synthetic route of 4687-25-6

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

4687-25-6,4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A stirred mixture of heterocycle-carboxaldehyde 5(1.0 mmol) and p-toluene-sulfonylmethyl isocyanide (TosMIC)(1.1 mmol, 0.21 g) in 1:1 DME/MeOH (15 mL, both anhydrous) wasrefluxed with Ambersep 900(OH) ion exchange resin (2.0 g, exchangecapacity 1.18 meq/mL) for 2 h. The reaction mixture wasfiltered, the resin was washed by MeOH twice (2 5 mL), and thecombined filtrates were concentrated under reduced pressure togive the crude product, which was purified by column chromatography on silica gel (eluent: petroleum ether/acetone 4:1) to afford the pure compound 6.

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Ming-Zhi; Jia, Chen-Yang; Gu, Yu-Cheng; Mulholland, Nick; Turner, Sarah; Beattie, David; Zhang, Wei-Hua; Yang, Guang-Fu; Clough, John; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 669 – 674;,
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