Heterocyclic Building Block-benzofuran

54008-77-4,54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a hot oven-dried Schlenk tube under N2 atmosphere were added Ph3Bi (0.25 mmol, 110 mg, 1.0 equiv), 2-bromobenzofuran (0.825 mmol, 163 mg, 3.3 equiv), Cs2CO3 (0.75 mmol, 244 mg, 3.0 equiv), Pd(OAc)2 (0.025 mmol, 5.6 mg, 0.1 equiv), PPh3 (0.1 mmol, 26 mg, 0.4 equiv), and NMP (3 mL) solvent. The resulting mixture was stirred in preheated oil bath at 90 C for 1 h. After the reaction is over, the mixture was cooled, quenched with dil HCl and extracted with ethyl acetate. The combined organic extract was washed with water, brine, and dried over MgSO4 and concentrated. The crude was subjected to silica gel column chromatography (230-400 mesh) using petroleum ether as the eluent to obtain the pure 2-phenylbenzofuran (2.1) as a white solid (140 mg, 96%). The product was characterized by spectroscopy and in comparison with the literature data.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Rao, Maddali L.N.; Awasthi, Dheeraj K.; Talode, Jalindar B.; Tetrahedron Letters; vol. 53; 21; (2012); p. 2662 – 2666;,
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610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

610-93-5, 6-Nitrophthalide (10 mmol) was dissolved in ethyl acetate (100 mL) and methanol (25 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.2 g). After 24 h the reaction mixture was filtered through a bed of celite and the filtrate was removed under reduced pressure.The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide. 6-Hydroxyphthalide was synthesized by reacting a cold suspension of 6-aminophthalide (3 mmol) in 10 mL H2SO4 (50%) with a cold solution of NaNO2 (3.5 mmol in 3 mL H2O) to yield the diazonium salt. The resulting solution was added to boiling (125 C) H2SO4 (50%, 20 mL) and the reaction mixture was boiled for 5 min. The reaction was rapidly cooled in an ice bath, and subsequently extracted to diethyl ether (3×20 mL). The ether portions were combined, washed with a saturated solution of NaHCO3 (25 mL) and dried over anhydrous Na2SO4. The ether was removed under reduced pressure, leaving the brown 6-hydroxyphthalide residue. Yield 65%; m.p. 198-200 C; 1H NMR (300MHz, DMSO) delta 5.25 (s, 2H), 7.15-7.18 (m, 2H), 7.39 (d, J=9.0 Hz, 1H); ESI-MS m/z: 150.9 [M+H]+.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Zhimin; Wu, Jiajia; Yang, Xuelian; Cai, Pei; Liu, Qiaohong; Wang, Kelvin D.G.; Kong, Lingyi; Wang, Xiaobing; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5929 – 5940;,
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18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Further purification by column chromatography on silica gel (eluted with ethyl acetate/heptane 3:1) yielded 3.2 g of pure 5-nitro-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran which crystallized upon standing. Mp: 108-114 C. 5-Amino-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran: To a solution of all of the 5-nitrobenzofuran in 90% ethanol (50 ml) kept at reflux were added small portions of Fe powder (in total 2.5 g) and concentrated HCl (in total 0.1 ml) during 10 min. The mixture was refluxed for another hour. The inorganic precipitates were filtered off and the mixture was poured onto brine and ethyl acetate (250 ml). work-up of the organic phase afforded 1 g of crystalline 5-aminobenzofuran derivative., 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

Reference£º
Patent; H. Lundbeck A/S; US5807889; (1998); A;,
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652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, General procedure: To a solution of compounds 2a-2h (5 mmol) in acetic anhydride (5 mL) and triethylamine (2.5 mL) was added ethyl acetoacetate (0.71 mL, 5.5 mmol) under argon. The reaction mixture was stirred at rt for 12 h and then poured into the mixture of concentrated HCl (6 g) and ice-water (6 g). After that, the reaction mixture was stirred at rt for 30 min, additional HCl (8.8 mL, 5M) was added into the mixture, and then the reaction mixture was refluxed for 2 h. After the crude product was cooled to rt, water (100 mL) was added and the reaction mixture was extracted with DCM (2 100 mL). The combined organic layers were washed with brine and then dried (Na2SO4). After removing the solvent, the residue was purified by flash column chromatography.

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Article; Guo, Shenquan; Zhang, Niuniu; Tang, Xiangzheng; Mao, Zhifeng; Zhang, Xuejing; Yan, Ming; Xuan, Yining; Chinese Chemical Letters; vol. 30; 2; (2019); p. 406 – 408;,
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Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 5-ethenyl-2-benzofuran-1(3H)-one: 5-Bromophthalide (50g, 235 mmol), potassium vinyltrifluoroborate (62.9 g, 469 mmol), and PdCl2(dppf)-CH2Cl2 Adduct (9.58 g, 11.7 mmol) wereadded to ethanol (500 mL) then TEA (65.4 mL, 469 mmol) was added. The reaction mixture wasdegassed then heated at reflux for 8 h. The reaction was worked up by diluting with ethyl acetate and washing with brine twice. The organic layer was dried and evaporated to dryness. The crudeproduct was purified by MPLC (silica, 600g column) with 25% EtOAc/hexane (3 L) then with30% EtOAc/Hexane (2 L) to yield the title compound.

64169-34-2, The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.,209256-42-8

To a solution of 2,3-dihydrobenzofuran-4-aldehyde (1g, 6.7 mmol) (Example 2, Part C) and dimethyl malonate 0.89 g, 6.7 mmol) in benzene (30 mL) was added piperidine (0.11 g, 1.4 mmol) and acetic acid (0.40 g, 6.7 mmol). The resulting solution was stirred for 18 hr with continuous removal of water. The solution was cooled to ambient temperature and concentrated. The residues was chromatographed on silica gel (ethyl acetat:hexane, 3:7) to give the title compound (1.5g).

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP1041980; (2005); B1;,
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Benzofuran | C8H6O – PubChem

13099-95-1, Ethyl 3-oxo-2,3-dihydrobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 10-mL glass tube equipped with a stirring bar was charged with benzofuranone 1 (0.60 mmol, 1.5 equiv), nitroallylic acetate 2 (0.40 mmol, 1 equiv), the catalyst K (0.04 mmol, 10 mol %), and CH2Cl2 (4.0 mL). The resulting solution was stirred at rt for 12 h. The solvent was evaporated under reduced pressure and the crude product was directly purified by flash column chromatography (PE/EtOAc from 20:1 to15:1) to provide the desired products 3., 13099-95-1

The synthetic route of 13099-95-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Long; Raabe, Gerhard; Enders, Dieter; Synthesis; vol. 51; 6; (2019); p. 1391 – 1398;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166599-84-4,Benzofuran-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of benzofuran-4-carboxylic acid (11 mg), PyBOP (35 mg), DIEA (0.030 mL) in dry DMF (0.15 mL), was added a solution of (2RS)-(2-aminomethyl-azetidin-1-yl)45-(4-fluoro-phenyl)-2-methyl-thiazol-4-A-methanone (20 mg) in dry DMF (0.1 mL). The resulting reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The aqueous phase was extracted once again with EA, the combined organic extracts were dried (MgSO4), filtered and concentrated to yield a crude light brown oil.FC (EA to DCM/MeOH: 98/2) gave 23 mg (78%) of the title compound as a white solid.LC-MS: rt=0.94 min, 450 [M+H]+.

166599-84-4, The synthetic route of 166599-84-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2010/222600; (2010); A1;,
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Benzofuran | C8H6O – PubChem

115010-11-2, 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1; N-[7-(4-piperidinyl)oxy-1-benzofuran-5-yl]-2-methoxy-5-methylbenzenesulfonamide; Example 1 was prepared as follows: 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide is produced starting from 2,3-dihydrobensofuran. Treatment with chlorosulfonic acid gives the corresponding sulfonyl chloride, which is iodinated using iodine monochloride. Aromatization is done using NBS, resulting in 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide after treatment with cresidine. Hydrolysis of 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide in alkaline solution using copper as catalyst results in 7-hydroxy-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide. Reaction with a methyl carbamate protected mesylate of 4-hydroxypiperidine, results in methyl 4-[(5-{[(2-methoxy-5-methylphenyl)amino]sulfonyl}-1-benzofuran-7-yl)oxy]piperidine-1-carboxylate, which is hydrolysed in alkaline solution giving the title compound.

115010-11-2, As the paragraph descriping shows that 115010-11-2 is playing an increasingly important role.

Reference£º
Patent; Caldirola, Patrizia; Johansson, Gary; Sutin, Lori; US2006/293361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

54008-77-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
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