Category: benzofurans

Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Characterization of a bombesin receptor on Swiss mouse 3T3 cells by affinity cross-linking. Author is Sinnett-Smith, James; Zachary, Ian; Rozengurt, Enrique.

A cell surface protein in Swiss 3T3 cells of apparent Mr 75,000-85,000 was identified previously by chem. crosslinking as a major component of the receptor for peptides of the bombesin family in these cells. Because bombesin-like peptides may interact with other cell surface mols., it was important to establish the correlation between receptor binding and functions of this complex and further characterize the Mr 75,000-85,000 cross-linked protein. Detailed time courses carried out at different temperatures demonstrated that the Mr 75,000-85,000 affinity-labeled band was the earliest cross-linked complex detected in Swiss 3T3 cells incubated with 125I-labeled gastrin-releasing peptide (125I-GRP). Furthermore, the ability of various nonradioactive bombesin agonists and antagonists to block the formation of the Mr 75,000-85,000 cross-linked complex correlated extremely well (r = 0.994) with the relative capacity of these peptides to inhibit 125I-GRP specific binding. Pretreatment with unlabeled GRP for up to 6 h caused only a slight decrease in both specific 125I-GRP binding and the affinity labeling of the Mr 75,000-85,000 protein. The cross-linked complex is a glycoprotein. First, solubilized affinity labeled Mr 75,000-85,000 complex applied to wheat germ lectin-Sepharose columns was eluted by addition of 0.3M N-acetyl-D-glucosamine. Second, treatment with endo-β-N-acetylglucosaminidase F reduced the apparent mol. weight of the affinity-labeled band from 75,000-85,000 to 43,000, indicating the presence of N-linked oligosaccharide groups.

After consulting a lot of data, we found that this compound(70539-42-3)Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 129-18-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Modification of the cardiac activity of digoxin by phenylbutazone and sodium salicylate. Author is Ammar, Elsayed M.; Elakkad, Ibrahim N.; Elbitar, Hussein H..

Daily oral treatment with the phenylbutazone-Na [129-18-0] or Na salicylate [54-21-7] for 2 weeks decreased the cardiac activity of digoxin (I) [20830-75-5], as indicated by an increase in its lethal dose in guinea pigs. The uptake of I by ventricular strips from rabbits, pretreated with phenylbutazone or sodium salicylate, was decreased, and this decrease may explain its decreased cardiac activity. Competition between the 2 antirheumatic drugs and I is discussed at both the plasma protein and the cardiac tissue levels. Thus, drug interactions and the subsequent decreased clinical effectiveness of I occur when I is prescribed in combination with phenylbutazone or sodium salicylate.

After consulting a lot of data, we found that this compound(129-18-0)Recommanded Product: 129-18-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about A new cleavable reagent for cross-linking and reversible immobilization of proteins. Author is Abdella, Peter M.; Smith, Paul K.; Royer, Garfield P..

A new bifunctional reagent was prepared for the crosslinking and reversible immobilization of proteins through their amino groups. This compound, ethylene glycol bis(succinimidyl succinate) (I), reacted rapidly with proteins, at pH 7 and at high dilution The resulting protein crosslinks were readily cleaved at pH 8.5 using hydroxylamine for 3-6 h at 37°. Substantial enzymic activity was observed with lactate dehydrogenase after such reversible crosslinking. Trypsin immobilized on agarose using this reagent retained full sp. activity, was stable for weeks in the cold, and could be released with hydroxylamine at 25°. This compound appears suitable for studies involving proteins with essential disulfide linkages.

After consulting a lot of data, we found that this compound(70539-42-3)Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Category: benzofurans. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Synthesis of 4-Hydroxy-2-oxo-1-pyrrolidineacetamide. Author is Chen, Xue; Lei, Yingjie; Ding, Mei; Bi, Ye.

Asym. reduction of Et 4-chloro-3-oxobutanoate to the title compound (i.e. (R)-oxyracetam) catalyzed by Saccharomyces cerevisiae and followed with the condensation of 2-amino-acetamide in alk. solution was investigated. The target compound was obtained in 52.7% yield and confirmed by sp. rotation and 1H NMR.

After consulting a lot of data, we found that this compound(90866-33-4)Category: benzofurans can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Systematic Investigation of Saccharomyces cerevisiae Enzymes Catalyzing Carbonyl Reductions. Author is Kaluzna, Iwona A.; Matsuda, Tomoko; Sewell, Aileen K.; Stewart, Jon D..

Eighteen key reductases from baker’s yeast (Saccharomyces cerevisiae) have been overproduced in Escherichia coli as glutathione S-transferase fusion proteins. A representative set of α- and β-keto esters was tested as substrates (11 total) for each purified fusion protein. The stereoselectivities of β-keto ester reductions depended both on the identity of the enzyme and the substrate structure, and some reductases yielded both L- and D-alcs. with high stereoselectivities. While α-keto esters were generally reduced with lower enantioselectivities, it was possible in all but one case to identify pairs of yeast reductases that delivered both alc. antipodes in optically pure form. Taken together, the results demonstrate not only that individual yeast reductases can be used to supply important chiral building blocks, but that GST-fusion proteins allow rapid identification of synthetically useful biocatalysts (along with their corresponding genes).

After consulting a lot of data, we found that this compound(90866-33-4)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Early cleavage of ethylene glycol bis(succinimidylsuccinate) (EGS)-linker moieties during enzymatic digestion of cross-linked proteins, the main research direction is sulfo EGS peptide enzymic digestion crosslinked protein.HPLC of Formula: 70539-42-3.

It has become popular to combine the crosslinking of proteins with mass spectrometry (MS) to study their tertiary structure or interactions. There are several difficulties with the method which make it a challenge. They include the limited availability of crosslinked peptides for MS anal. due to low yield of the crosslinking reaction and unwanted side chem. Recently, the authors have pointed out the uncontrolled quenching of azide linkers by buffer components rendering them almost useless for the intended task. Here, the authors describe a phenomenon involving cleavable crosslinkers. They have been designed to overcome the drawback that crosslinked peptides provide poor gas-phase fragmentation mass spectra because of their branched structure. Moreover, isotope coding on such linkers may assist in finding the low-abundance crosslinked peptides in mass spectra as described for ethylene glycol bis(succinimidylsuccinate) (EGS). In some of the authors’ experiments, this compound provided better crosslinking yields compared to other N-hydroxysuccinimide-derived reagents as detected by one-dimensional sodium dodecyl sulfate PAGE. For best results from crosslinking experiments using cleavable agents such as EGS, careful control of sample preparation protocols for early hydrolysis products is advisable.

After consulting a lot of data, we found that this compound(70539-42-3)HPLC of Formula: 70539-42-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 2923-28-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about The kinetic substitution reactions and structural analysis of manganese(I) acetylacetonato complexes. Author is Mokolokolo, Petrus P.; Alexander, Orbett T.; Brink, Alice; Visser, Hendrik G..

The methanol substitution reactions in the manganese acetylacetonato complex, fac-[Mn(CO)3(acac)(CH3OH)], was kinetically studied with a range of entering ligands including pyridine (Py), imidazole (Im) and 4-dimethylaminopyridine (DMAP). All the complexes were characterized by NMR, UV-visible and IR spectroscopy. Moreover, crystal structures of fac-[Mn(CO)3(acac)(CH3OH)] (1), fac-[Mn(CO)3(acac)(Py)] (2) and fac-[Mn(CO)3(acac)(DMAP)] (3) are reported. The substitution of methanol in fac-[Mn(CO)3(acac)(CH3OH)] (1) by DMAP is ∼2 times faster than Py, and 1.7 times faster when compared to Im. The results correlate well with the pKa of the entering nucleophile where pyridine (Py) < imidazole (Im) < 4-dimethylaminopyridine (DMAP). The activation parameters for 1 were determined as ΔH≠ = 73.9 ± 0.6 kJ mol-1 and the entropy of activation ΔS≠ = -28 ± 2 JK-1 indicating an interchange associative mechanism. The article 《The kinetic substitution reactions and structural analysis of manganese(I) acetylacetonato complexes》 also mentions many details about this compound(2923-28-6)Recommanded Product: 2923-28-6, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Stereoselective Synthesis of 5-Substituted Pyrrolo[1,2-c]imidazol-3-ones: Access to Annulated Chiral Imidazol(in)ium Salts, published in 2010-01-01, which mentions a compound: 767291-67-8, mainly applied to pyrroloimidazolone stereoselective lithiation phosphorus oxychloride salt formation; heterocyclic carbene precursor stereoselective preparation palladium complexation; palladium heterocyclic carbene complex preparation, Name: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A two-step synthesis of N-heterocyclic carbene (NHC) precatalysts by diastereoselective or enantioselective lithiation of pyrrolo[1,2-c]imidazol-3-ones followed by POCl3-induced salt formation is described. The resulting 3-chloro-pyrroloimidazol(in)ium salts may be coordinated to palladium(II) upon NHC generation with t-BuLi at low temperature The method may facilitate exploitation of these compounds as chiral organocatalysts or ligands in metal catalysis.

Although many compounds look similar to this compound(767291-67-8)Name: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, numerous studies have shown that this compound(SMILES:CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Category: benzofurans. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Quaternary structure of Artemia haemoglobin II: analysis of T and C polymer alignment and interpolymer interface. Author is Chyou, David T.; Rawle, Vincent L.; Trotman, Clive N. A..

The brine shrimp Artemia expresses four different types of Hb subunits namely C1, C2, T1 and T2. Two of these four subunits dimerize in different combinations to produce the three isoforms of the heterodimeric Artemia Hb: HbI (C1 and C2), HbII (C1 and T2) and HbIII (T1 and T2). Previous biochem., biophys. and computational analyses demonstrate that the T and C polymers are rings of nine concatenated globin domains, which are covalently joined by interdomain linkers. Two such rings stacked coaxially give the functional mol. This research aimed to construct a quaternary structural model of Artemia HbII that shows the interpolymer interface and domain-domain alignment, using the MS3D (mass spectrometry for three dimensional anal.) approach. This involved introducing chem. crosslinks between the two polymers, cleaving with trypsin and analyzing the resulting products by mass spectrometry. This was followed by computational anal. of the mass spectrometry data using the program SearchXlinks to identify putatively crosslinked peptides. Six putative EGS (ethylene glycol bis[succinimidylsuccinate]) crosslinked tryptic peptides were identified. All of them support a model in which the EF helixes of all domains are in contact along the interpolymer surface, and Domain 1 of the T-polymer aligns with Domain 1 of the C-polymer. Any two adjacent interpolymer domain pairs contact through the early Helix H and early Helix A. The orientation of domains is different from the subunit proposed model proposed previously by this group. Crosslinking with GMBS (N-[γ-maleimidobutyryloxy]succinimide ester) was also performed, and the results show good agreement with this model. The interpolymer EF-contact allows the hydrophobic E and F helixes to be buried in the interface and therefore allow the complex to solubilize readily to facilitate efficient oxygen transport. Furthermore the EF-contact is a common contact in cooperative Hbs and thus the model is consistent with the cooperative behavior of Artemia HbII.

Although many compounds look similar to this compound(70539-42-3)Category: benzofurans, numerous studies have shown that this compound(SMILES:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70539-42-3, is researched, Molecular C18H20N2O12, about Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts, the main research direction is VIP receptor lymphoblast.Related Products of 70539-42-3.

125I-labeled VIP  [37221-79-7] was covalently crosslinked with its binding sites on intact cultured human lymphoblasts by each of 3 bifunctional reagents: disuccinimidyl suberate  [68528-80-3], ethylene glycol bis(succinimidyl succinate) [82540-27-0], and N-succinimidyl 6-(4′-azido-2′-nitrophenylamino)hexanoate  [64309-05-3]. A 4th crosslinking agent with a shorter chain length, N-hydroxysuccinimidyl 4-azidobenzoate  [53053-08-0], was much less effective in crosslinking 125I-VIP to the site. Anal. by SDS-polyacrylamide gel electrophoresis and autoradiog. demonstrated a band of mol. weight (Mr) ∼50,000, regardless of which crosslinker was used. The labeling of this band was specific in that it was prevented by 10-6M unlabeled VIP and was partially blocked by the homologous hormones secretin  [1393-25-5] and glucagon  [9007-92-5]. The relative potencies of these peptides in blocking the cross-linking of 125I-VIP to the Mr ∼50,000 band of the lymphoblasts (VIP > secretin ≥ glucagon) were similar to those previously found for competitive inhibition of 125I-VIP binding to its putative high-affinity receptor on these cells. The covalent crosslinking required a bifunctional reagent and it was dependent on both the number of Molt cells and the concentration of 125I-VIP. The apparent mol. weight of the crosslinked species was unchanged by treatment with dithiothreitol. Apparently, the Mr = 50,000 species represents 125I-VIP crosslinked to a specific plasma membrane receptor and the receptor does not contain interchain disulfide bonds.

Although many compounds look similar to this compound(70539-42-3)Related Products of 70539-42-3, numerous studies have shown that this compound(SMILES:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem