Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70539-42-3, is researched, Molecular C18H20N2O12, about Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts, the main research direction is VIP receptor lymphoblast.Related Products of 70539-42-3.
125I-labeled VIP [37221-79-7] was covalently crosslinked with its binding sites on intact cultured human lymphoblasts by each of 3 bifunctional reagents: disuccinimidyl suberate [68528-80-3], ethylene glycol bis(succinimidyl succinate) [82540-27-0], and N-succinimidyl 6-(4′-azido-2′-nitrophenylamino)hexanoate [64309-05-3]. A 4th crosslinking agent with a shorter chain length, N-hydroxysuccinimidyl 4-azidobenzoate [53053-08-0], was much less effective in crosslinking 125I-VIP to the site. Anal. by SDS-polyacrylamide gel electrophoresis and autoradiog. demonstrated a band of mol. weight (Mr) ∼50,000, regardless of which crosslinker was used. The labeling of this band was specific in that it was prevented by 10-6M unlabeled VIP and was partially blocked by the homologous hormones secretin [1393-25-5] and glucagon [9007-92-5]. The relative potencies of these peptides in blocking the cross-linking of 125I-VIP to the Mr ∼50,000 band of the lymphoblasts (VIP > secretin ≥ glucagon) were similar to those previously found for competitive inhibition of 125I-VIP binding to its putative high-affinity receptor on these cells. The covalent crosslinking required a bifunctional reagent and it was dependent on both the number of Molt cells and the concentration of 125I-VIP. The apparent mol. weight of the crosslinked species was unchanged by treatment with dithiothreitol. Apparently, the Mr = 50,000 species represents 125I-VIP crosslinked to a specific plasma membrane receptor and the receptor does not contain interchain disulfide bonds.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem