Category: benzofurans. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Quaternary structure of Artemia haemoglobin II: analysis of T and C polymer alignment and interpolymer interface. Author is Chyou, David T.; Rawle, Vincent L.; Trotman, Clive N. A..
The brine shrimp Artemia expresses four different types of Hb subunits namely C1, C2, T1 and T2. Two of these four subunits dimerize in different combinations to produce the three isoforms of the heterodimeric Artemia Hb: HbI (C1 and C2), HbII (C1 and T2) and HbIII (T1 and T2). Previous biochem., biophys. and computational analyses demonstrate that the T and C polymers are rings of nine concatenated globin domains, which are covalently joined by interdomain linkers. Two such rings stacked coaxially give the functional mol. This research aimed to construct a quaternary structural model of Artemia HbII that shows the interpolymer interface and domain-domain alignment, using the MS3D (mass spectrometry for three dimensional anal.) approach. This involved introducing chem. crosslinks between the two polymers, cleaving with trypsin and analyzing the resulting products by mass spectrometry. This was followed by computational anal. of the mass spectrometry data using the program SearchXlinks to identify putatively crosslinked peptides. Six putative EGS (ethylene glycol bis[succinimidylsuccinate]) crosslinked tryptic peptides were identified. All of them support a model in which the EF helixes of all domains are in contact along the interpolymer surface, and Domain 1 of the T-polymer aligns with Domain 1 of the C-polymer. Any two adjacent interpolymer domain pairs contact through the early Helix H and early Helix A. The orientation of domains is different from the subunit proposed model proposed previously by this group. Crosslinking with GMBS (N-[γ-maleimidobutyryloxy]succinimide ester) was also performed, and the results show good agreement with this model. The interpolymer EF-contact allows the hydrophobic E and F helixes to be buried in the interface and therefore allow the complex to solubilize readily to facilitate efficient oxygen transport. Furthermore the EF-contact is a common contact in cooperative Hbs and thus the model is consistent with the cooperative behavior of Artemia HbII.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem