Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Systematic Investigation of Saccharomyces cerevisiae Enzymes Catalyzing Carbonyl Reductions. Author is Kaluzna, Iwona A.; Matsuda, Tomoko; Sewell, Aileen K.; Stewart, Jon D..
Eighteen key reductases from baker’s yeast (Saccharomyces cerevisiae) have been overproduced in Escherichia coli as glutathione S-transferase fusion proteins. A representative set of α- and β-keto esters was tested as substrates (11 total) for each purified fusion protein. The stereoselectivities of β-keto ester reductions depended both on the identity of the enzyme and the substrate structure, and some reductases yielded both L- and D-alcs. with high stereoselectivities. While α-keto esters were generally reduced with lower enantioselectivities, it was possible in all but one case to identify pairs of yeast reductases that delivered both alc. antipodes in optically pure form. Taken together, the results demonstrate not only that individual yeast reductases can be used to supply important chiral building blocks, but that GST-fusion proteins allow rapid identification of synthetically useful biocatalysts (along with their corresponding genes).
After consulting a lot of data, we found that this compound(90866-33-4)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem