Category: benzofurans

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3 ) is researched.Application of 70539-42-3.Massague, Joan; Guillette, Barbara J.; Czech, Michael P. published the article 《Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues》 about this compound( cas:70539-42-3 ) in Journal of Biological Chemistry. Keywords: multiplication stimulating activity receptor; membrane multiplication stimulating activity receptor; adipose multiplication stimulating activity receptor; placenta multiplication stimulating activity receptor; liver multiplication stimulating activity receptor. Let’s learn more about this compound (cas:70539-42-3).

Plasma membranes from rat adipocytes and liver and from human placenta were labeled by covalent crosslinking to membrane-bound 125I-labeled multiplication-stimulating activity (125I-MSA) with 3 different bishydroxysuccinimide esters: disuccinimidyl suberate, disuccinimidyl succinate, and ethyleneglycolylbis(succinimidyl succinate). Dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiog. anal. of the 125I-MSA-labeled material in the presence of dithiothreitol reveals 1 single-labeled protein migrating with an apparent Mr = 255,000 regardless of the kind and concentration of crosslinker used. Electrophoresis in the absence of reductant indicates that the affinity-labeled species is not disulfide-linked to any other protein in the native plasma membrane, but contains internal disulfide bonds that compact its structure. The labeling of the Mr = 255,000 species increases with increasing concentrations of 125I-MSA of 0.3-3 nM. Labeling is abolished in a competitive manner by nonradioactive MSA but not by similar concentrations of insulin, proinsulin, or epidermal growth factor in all 3 tissues examined The unique labeling of this Mr = 225,000 membrane component and its selective inhibition by MSA suggest that this protein is a plasma membrane receptor for MSA.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Application of 70539-42-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate(SMILESS: O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O,cas:70539-42-3) is researched.Application of 70539-42-3. The article 《Cleavable ester-linked magnetic nanoparticles for labeling of solvent-exposed primary amine groups of peptides/proteins》 in relation to this compound, is published in Analytical Biochemistry. Let’s take a look at the latest research on this compound (cas:70539-42-3).

To study the solvent-exposed lysine residues of peptides/proteins, we previously reported disulfide-linked N-hydroxysuccinimide ester-modified silica-coated iron oxide magnetic nanoparticles (NHS-SS-SiO2@Fe3O4 MNPs). The presence of a disulfide bond in the linker limits the use of disulfide reducing agent during protein digestion and allows unwanted disulfide formation between the MNPs and protein. In the current work, the disulfide bond was replaced with a cleavable ester group to synthesize NHS ester-modified SiO2@Fe3O4 MNPs. Use of the cleavable ester group provides an improved method for protein labeling and allows the use of disulfide reducing agents during protein digestion.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Application of 70539-42-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3939-12-6, is researched, Molecular C6H3FN2, about Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC, the main research direction is aryl halide amine HPMC catalyst nucleophilic aromatic substitution reaction; aromatic amine preparation green chem.Name: 6-Fluoronicotinonitrile.

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein.

Different reactions of this compound(6-Fluoronicotinonitrile)Name: 6-Fluoronicotinonitrile require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Category: benzofurans. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about The stability and functionality of chemically crosslinked microtubules. Author is Boal, Andrew K.; Tellez, Hernesto; Rivera, Susan B.; Miller, Nicholas E.; Bachand, George D.; Bunker, Bruce C..

A variety of bifunctional crosslinking agents have been explored for stabilizing microtubule shuttles used for the active transport of nanomaterials in artificial environments. Crosslinking agents that target amine residues form intertubulin crosslinks that produce crosslinked microtubules (CLMTs) with structural and functional lifetimes that can be up to four times as long as those achieved with taxol stabilization. Such CLMTs are stable at temperatures down to -10°C, are resistant to depolymerization induced by metal ions such as Ca2+, and yet continue to be adsorbed and transported by self-assembled monolayers containing the motor protein kinesin. However, crosslinkers that target cysteine residues depolymerize the MTs, probably by interfering with the guanosine triphosphate binding site. The impact of crosslink attributes, including terminal group chem., chain length, crosslink d., and specific location on the tubulin surface, on microtubule stability and functionality are discussed.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Category: benzofurans require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70539-42-3, is researched, SMILESS is O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O, Molecular C18H20N2O12Journal, Comparative Study, Article, Research Support, Non-U.S. Gov’t, Biochemical and Biophysical Research Communications called The dimerization domain of upstream binding factor contains multiple helical structures, Author is Lai, Yu-Shen; Tseng, Hua-Bin; Hu, Chin-Hwa, the main research direction is transcription factor UBF dimerization binding DNA; upstream binding factor dimerization binding DNA.Formula: C18H20N2O12.

The upstream binding factor, UBF, is an RNA polymerase I transcription factor which contains multiple DNA binding domains and a novel protein dimerization domain. Active UBF forms homodimers in vivo through the intramol. interactions of its dimerization domain, which spans a hundred amino-terminal residues. In the presence of both UBF dimerization domain and its immediately adjacent lysine-rich basic DNA binding domain, the E. coli expressed recombinant polypeptide, dbUBF (dimerization plus basic motifs of UBF), forms homodimers in vitro and binds to double-stranded DNA nonselectively. In gel retardation assay, dbUBF dimers make multiple shift-ladders corresponding to numerous protein dimer-DNA complexes. The UBF dimerization domain contains multiple helical structures, as predicted by EMBO-PHD program. Most of hydrophobic residues in the dimerization domain are confirmed in the hydrophobic phase of these hypothetic helixes. Mutating these hydrophobic residues to glutamate prohibits dbUBF association and gives a different shift pattern in gel retardation assay. The results we present here argue that UBF association is largely exerted by the hydrophobic interactions between the multiple helixes to bring two mols. together.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Formula: C18H20N2O12 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C6H11ClO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Stereoselective reduction by ethyl 4-chloro-3-oxobutanoate by a microbial aldehyde reductase in an organic solvent-water diphasic system. Author is Shimizu, Sakayu; Kataoka, Michihiko; Katoh, Masaaki; Morikawa, Tadashi; Miyoshi, Teruzo; Yamada, Hideaki.

Enzyme-catalyzed asym. reduction of Et 4-chloro-3-oxobutanoate (I) in an organic solvent-water diphasic system was studied. NADPH-dependent aldehyde reductase isolated from Sporobolomyces salmonicolor AKU4429 and glucose dehydrogenase were used as catalysts for reduction of I and recycling of NADPH, resp., in this system. In an aqueous system I was unstable. Inhibition of the reaction and inactivation of the enzymes by the substrate and the product were also observed BuOAc-H2O diphasic system very efficiently overcame these limitations. In a 1600-mL-1600-mL scale diphasic reaction, Et (R)-4-chloro-3-hydroxybutanoate (0.80 mol; 86% enantiomeric excess) was produced from I in a molar yield of 95.4% with an NADPH turnover of 5500 mol/mol.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)COA of Formula: C6H11ClO3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Mathematical modeling of asymmetric reduction of ethyl 4-chloro acetoacetate by bakers’ yeast, the main research direction is chloro acetoacetate stereoselective enzymic reduction Saccharomyces; stereoselective reduction reaction kinetics modeling.Application of 90866-33-4.

A mathematic model was developed to simulate the asym. reduction of Et 4-chloro acetoacetate (ECA) by bakers’ yeast. The model of the process considered the kinetics of enzymic reaction, the effect of substrate inhibition and the spontaneous degradation of the substrate. The reaction kinetics of the ECA degradation was determined empirically. The inhibition by the substrate was analyzed and the apparent kinetic constants of the overall enzymic reaction, of the S-enzymes and of the R-enzymes, were estimated individually. The system of equations was solved numerically using the Runge-Kutta method. The close correlation between the predicted and exptl. results concerning product formation, reaction yield and optical purity of product under various substrate concentrations, implied the reliability of the established model.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application of 90866-33-4 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 70539-42-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Chemical crosslinking of mitochondrial NADH dehydrogenase from bovine heart. Author is Cleeter, Michael W. J.; Banister, Susan H.; Ragan, C. Ian.

The structure of bovine heart mitochondrial NADH dehydrogenase was investigated by using 2 cleavable crosslinking agents, disuccinimidyl tartrate and (ethylene glycol)yl bis(succinimidyl succinate). Crosslinking was analyzed primarily by immunoblotting to detect products containing subunits of the Fe-protein fraction from chaotropic resolution of the enzyme, namely those of 75, 49, 30, and 13 kilodaltons. Crosslinks were identified between these 4 subunits, from these subunits to the largest subunit of the flavoprotein fraction (which contains the active site for NADH), and from these subunits to polypeptides in the hydrophobic shell (which surrounds the hydrophilic Fe-protein and flavoprotein fractions).

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Recommanded Product: 70539-42-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electric Literature of C9H7BrO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about Catalytic cascade aldol-cyclization of tertiary ketone enolates for enantioselective synthesis of keto-esters with a C-F quaternary stereogenic center. Author is Sha, Wanxing; Zhang, Lijun; Zhang, Wenzhong; Mei, Haibo; Soloshonok, Vadim A.; Han, Jianlin; Pan, Yi.

The first asym. catalytic aldol-cyclization reaction of detrifluoroacetylatively in situ generated enolates with Me 2-formylbenzoate was reported. This reaction tolerates a wide range of substrates, affording fluorinated quaternary stereogenic α,α-dialkyl/cyclo-alkyl-β-ketoesters, e.g., I, with good yields, high diastereo-(94% de) and enantioselectivity (96% ee) at room temperature

Different reactions of this compound(Methyl 4-bromo-2-formylbenzoate)Electric Literature of C9H7BrO3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Advanced Synthesis & Catalysis called New chiral diphosphine ligands designed to have a narrow dihedral angle in the biaryl backbone, Author is Saito, Takao; Yokozawa, Tohru; Ishizaki, Takero; Moroi, Takashi; Sayo, Noboru; Miura, Takashi; Kumobayashi, Hidenori, the main research direction is chiral diphosphine ligand preparation narrow dihedral angle biaryl backbone; bibenzodioxole diyl diarylphosphine ligand preparation ruthenium complexation; asym catalytic hydrogenation catalyst benzodioxolediyl diarylphosphine ruthenium complex preparation; carbonyl compound asym catalytic hydrogenation catalyst benzodioxolediyl diarylphosphine ruthenium; SEGPHOS ruthenium complex preparation asym hydrogenation catalyst.Safety of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

A series of novel optically active diphosphine ligands, (4,4′-bi-1,3-benzodioxole)-5,5′-diyl-bis(diarylphosphine)s, which are called SEGPHOS, has been designed and synthesized with dihedral angles in the Ru complexes being less than that in the corresponding BINAP-Ru complex. The stereorecognition abilities of SEGPHOS-Ru complex catalysts in the asym. catalytic hydrogenation of a wide variety of carbonyl compounds are superior to those observed with BINAP-Ru complex catalysts.

《New chiral diphosphine ligands designed to have a narrow dihedral angle in the biaryl backbone》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Safety of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem