COA of Formula: C6H11ClO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Stereoselective reduction by ethyl 4-chloro-3-oxobutanoate by a microbial aldehyde reductase in an organic solvent-water diphasic system. Author is Shimizu, Sakayu; Kataoka, Michihiko; Katoh, Masaaki; Morikawa, Tadashi; Miyoshi, Teruzo; Yamada, Hideaki.
Enzyme-catalyzed asym. reduction of Et 4-chloro-3-oxobutanoate (I) in an organic solvent-water diphasic system was studied. NADPH-dependent aldehyde reductase isolated from Sporobolomyces salmonicolor AKU4429 and glucose dehydrogenase were used as catalysts for reduction of I and recycling of NADPH, resp., in this system. In an aqueous system I was unstable. Inhibition of the reaction and inactivation of the enzymes by the substrate and the product were also observed BuOAc-H2O diphasic system very efficiently overcame these limitations. In a 1600-mL-1600-mL scale diphasic reaction, Et (R)-4-chloro-3-hydroxybutanoate (0.80 mol; 86% enantiomeric excess) was produced from I in a molar yield of 95.4% with an NADPH turnover of 5500 mol/mol.
Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)COA of Formula: C6H11ClO3 require different conditions, so the reaction conditions are very important.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem