Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Industrial & Engineering Chemistry Research called A Complex Process of Asymmetric Synthesis of β-Hydroxy Ester by Baker’s Yeast Accompanied by Resin Adsorption, Author is Yang, Zhong-Hua; Yao, Shan-Jing; Guan, Yi-Xin, the main research direction is bakers yeast asym reduction resin adsorption.SDS of cas: 90866-33-4.
Asym. reduction of β-oxo ester to chiral β-hydroxy ester by yeast cells is one of the most promising routes for synthesis of chiral pharmaceutical intermediates. But the stereoselectivity and initial substrate concentration of this asym. reduction reaction are usually unsatisfactory. When asym. reduction of Et 4-chloro-3-oxobutanoate to chiral Et 4-chloro-3-hydroxybutanoate by baker’s yeast was chosen as the model reaction, it was investigated to improve the stereoselectivity and initial substrate concentration of this asym. reduction reaction by introducing resin to slowly release the substrate and in situ adsorb the product. The experiments indicated that the stereoselectivity could be promoted from about 78% to 95% with this technique, and the initial substrate concentration could be increased from 70 to 150 mmol/L, but the yield and stereoselectivity were still satisfactory with introducing resin.
Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)SDS of cas: 90866-33-4 require different conditions, so the reaction conditions are very important.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem