Category: 3939-12-6

Quality Control of 6-Fluoronicotinonitrile. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about An efficient synthesis of highly functionalized chiral lactams. Author is Ornelas, Martha A.; Gonzalez, Javier; Sach, Neal W.; Richardson, Paul F.; Bunker, Kevin D.; Linton, Angelica; Kephart, Susan E.; Pairish, Mason; Guo, Chuangxing.

A new method was developed to synthesize highly functionalized lactams, e.g., I, via a one pot reductive amination/lactam formation reaction. This methodol. is amenable for parallel synthesis and was used to prepare a large number of lactam analogs in a library format with good ee (de) retention.

《An efficient synthesis of highly functionalized chiral lactams》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Fluoronicotinonitrile)Quality Control of 6-Fluoronicotinonitrile.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3939-12-6, is researched, Molecular C6H3FN2, about Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC, the main research direction is aryl halide amine HPMC catalyst nucleophilic aromatic substitution reaction; aromatic amine preparation green chem.Name: 6-Fluoronicotinonitrile.

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein.

Different reactions of this compound(6-Fluoronicotinonitrile)Name: 6-Fluoronicotinonitrile require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liang, Dong-Dong; Guo, Shen-Yi; Tong, Shuo; Wang, Mei-Xiang published an article about the compound: 6-Fluoronicotinonitrile( cas:3939-12-6,SMILESS:N#CC1=CC=C(F)N=C1 ).Reference of 6-Fluoronicotinonitrile. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3939-12-6) through the article.

A practical synthetic method has been developed for polyfunctionalized biaryls e.g., I, e.g., II based on a facile one-pot nucleophilic aromatic substitution (SNAr) reaction and [5,5]- or [3,3]-sigmatropic rearrangement reaction cascade. Under mild basic conditions, N-arylhydroxylamines ArN(R)OH (R = Bn, Me, Boc; Ar = Ph, 6-fluoropyridin-2-yl, 3,5-dichlorophenyl, etc.) reacted with o-activated fluoro (het)arenes R1F (R1 = 2-nitrophenyl, 6-fluoropyridin-2-yl, 4-cyanophenyl, etc.) to form N,O-diarylhydroxylamine intermediates which underwent spontaneously selective [5,5]-sigmatropic rearrangement reaction to produce diverse functionalized 4-amino-4′-hydroxy-1,1′-biaryls e.g., I. A sequential SNAr reaction and [3,3]-sigmatropic rearrangement took place between N-arylhydroxylamines and 2-fluoropyridine derivatives or 4-fluorobenzonitrile to afford functionalized 2-amino-2′-hydroxy-1,1′-biaryls e.g., II. As invaluable and unique building blocks, the resulting biaryls were applied in the straightforward synthesis of N2, O2-coronarene, carbazole, aza- and diaza carbazole derivatives e.g, III.

The article 《Polyfunctionalized biaryls accessed by a one-pot nucleophilic aromatic substitution and sigmatropic rearrangement reaction cascade under mild conditions》 also mentions many details about this compound(3939-12-6)Reference of 6-Fluoronicotinonitrile, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives, published in 2019-02-28, which mentions a compound: 3939-12-6, Name is 6-Fluoronicotinonitrile, Molecular C6H3FN2, SDS of cas: 3939-12-6.

A series of nitrobenzamide derivatives containing N-benzyl or N-pyridinylmethyl moieties I [R = H, 5-CF3, 5-F, etc.; R1 = F, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.; X = Y = CH; X = CH, Y = N; X = N, Y = CH] was designed and synthesized as new anti-tubercular agents. Many of synthesized compounds I exhibited potent in vitro antitubercular activity. Four compounds I [R = 5-NO2; R1 = 4-MeO, 4-(trifluoromethyl)-1-piperidyl, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl] had not only the same excellent MIC values against both drug-sensitive MTB strain H37Rv and two drug-resistant clin. isolates as PBTZ169 and the lead I [R = 5-NO2; R1 = 4-(trifluoromethyl)-1-piperidyl; X = Y = CH], but also acceptable safety indexes.

The article 《Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives》 also mentions many details about this compound(3939-12-6)SDS of cas: 3939-12-6, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of 6-Fluoronicotinonitrile. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer. Author is Mitch, Charles H.; Quimby, Steven J.; Diaz, Nuria; Pedregal, Concepcion; de la Torre, Marta G.; Jimenez, Alma; Shi, Qing; Canada, Emily J.; Kahl, Steven D.; Statnick, Michael A.; McKinzie, David L.; Benesh, Dana R.; Rash, Karen S.; Barth, Vanessa N..

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (25) had a Ki = 0.565 nM for κ opioid receptor binding while having a Ki = 35.8 nM for μ opioid receptors and a Ki = 211 nM for δ opioid receptor binding. Compound 25 was also a potent antagonist of κ opioid receptors when tested in vitro using a [35S]-guanosine 5’O-[3-thiotriphosphate] ([35S]GTP-γ-S) functional assay in CHO cells expressing cloned human opioid receptors. Compounds were also evaluated for potential use as receptor occupancy tracers. Tracer evaluation was done in vivo, using liquid chromatog.-tandem mass spectrometry (LC/MS/MS) methods, precluding the need for radiolabeling. (S)-3-Chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (18) was found to have favorable properties for a tracer for receptor occupancy, including good specific vs. nonspecific binding and good brain uptake.

After consulting a lot of data, we found that this compound(3939-12-6)Quality Control of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Fluoronicotinonitrile(SMILESS: N#CC1=CC=C(F)N=C1,cas:3939-12-6) is researched.Synthetic Route of CAgF3O3S. The article 《Regulating force-resistance and acid-responsiveness of pure organics with persistent phosphorescence via simple isomerization》 in relation to this compound, is published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. Let’s take a look at the latest research on this compound (cas:3939-12-6).

Stimulus-responsive purely organic room-temperature phosphorescence materials have been drawing massive attention due to their wide applications. Pyridine rings are introduced to supply π orbitals and cyanogroups are incorporated to boost the ISC efficiency by promoting the spin-forbidden transition. These groups are anticipated to enable the target mol. with multi-responsiveness because of the protonation of pyridine and their good crystallinity, which are able to regulate the acid-responsiveness and force-responsiveness, resp. Based on the above design concept, four new D-A-A’ type mols. using carbazole as the donor and the pyridine ring and cyanogroup as acceptors were designed and synthesized. The D-A-A’ structure bestows these isomers with an evident intramol. charge transfer (ICT) feature, particularly for 2-CNPyCZ and 3-CNPyCZ. All the isomers show intense long-lived phosphorescence with a lifetime over 500 ms. Particularly, 4-CNPyCZ has a high phosphorescence quantum yield of 27.1% owing to the strong intermol. interactions that stabilize the T*1 excitons. Interestingly, four isomers could retain their long-lived afterglow even after being heavily ground and the afterglow shows well resistance to external forces due to high crystallinity. 4-CNPyCZ manifests unique mechanochromism owing to the fluorescence shift and intensity change of phosphorescence. Moreover, the four isomers demonstrate distinctive acid-responsiveness and give out colorful emissions because the electron cloud dispersion of the nitrogen atom in the pyridine ring varied when altering the position of the cyanogroup. To the best of our knowledge, this is a limited work on room temperature phosphorescence about systematically regulating the responsiveness to external stimuli and proposing an effective mol. design strategy.

After consulting a lot of data, we found that this compound(3939-12-6)COA of Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C6H3FN2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors. Author is Yeh, Vince S. C.; Patel, Jyoti R.; Yong, Hong; Kurukulasuriya, Ravi; Fung, Steven; Monzon, Katina; Chiou, William; Wang, Jiahong; Stolarik, Deanne; Imade, Hovis; Beno, David; Brune, Michael; Jacobson, Peer; Sham, Hing; Link, J. T..

A series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biol. evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.

After consulting a lot of data, we found that this compound(3939-12-6)Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics, published in 2020-04-15, which mentions a compound: 3939-12-6, mainly applied to triazolopyridinone derivative preparation multireceptor atypical antipsychotic agent; 5-HT1A receptor; Antipsychotic; Multireceptor; Triazolopyridinone, Safety of 6-Fluoronicotinonitrile.

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.

After consulting a lot of data, we found that this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Ferrara, Marco; Prandi, Adolfo; Randazzo, Pietro; Ronzoni, Silvano; Sinisi, Roberta; Seneci, Pierfausto; Summa, Vincenzo; Gallo, Mariana; Veneziano, Maria; Cellucci, Antonella; Mazzocchi, Nausicaa; Menegon, Andrea; Di Fabio, Romano researched the compound: 6-Fluoronicotinonitrile( cas:3939-12-6 ).Recommanded Product: 6-Fluoronicotinonitrile.They published the article 《Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS》 about this compound( cas:3939-12-6 ) in ACS Medicinal Chemistry Letters. Keywords: acid sensing ion channel inhibitor CNS. We’ll tell you more about this compound (cas:3939-12-6).

Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chem. starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound I is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.

Although many compounds look similar to this compound(3939-12-6)Recommanded Product: 6-Fluoronicotinonitrile, numerous studies have shown that this compound(SMILES:N#CC1=CC=C(F)N=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3939-12-6, is researched, Molecular C6H3FN2, about Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides, the main research direction is radiofluorination peptide triflyl pyridine trimethylammonium diazabicyclooctane.Reference of 6-Fluoronicotinonitrile.

Radiolabeling of peptides with fluorine-18 is hurdled by their chem. sensitivity and complicated processes. Original triflyl-pyridine intermediates afforded ammonium precursors that were radiolabeled at low temperature From that study, a generic tag has been designed to allow a simple one-step/late-stage radiolabelling of peptides. The strategy has been transposed to an automated “”on-resin”” radiolabelling.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem