Brief introduction of 3939-12-6

After consulting a lot of data, we found that this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics, published in 2020-04-15, which mentions a compound: 3939-12-6, mainly applied to triazolopyridinone derivative preparation multireceptor atypical antipsychotic agent; 5-HT1A receptor; Antipsychotic; Multireceptor; Triazolopyridinone, Safety of 6-Fluoronicotinonitrile.

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.

After consulting a lot of data, we found that this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem