In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics, published in 2020-04-15, which mentions a compound: 3939-12-6, mainly applied to triazolopyridinone derivative preparation multireceptor atypical antipsychotic agent; 5-HT1A receptor; Antipsychotic; Multireceptor; Triazolopyridinone, Safety of 6-Fluoronicotinonitrile.
A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.
After consulting a lot of data, we found that this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem