Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3939-12-6, is researched, Molecular C6H3FN2, about Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC, the main research direction is aryl halide amine HPMC catalyst nucleophilic aromatic substitution reaction; aromatic amine preparation green chem.Name: 6-Fluoronicotinonitrile.
The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein.
Different reactions of this compound(6-Fluoronicotinonitrile)Name: 6-Fluoronicotinonitrile require different conditions, so the reaction conditions are very important.