So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Ferrara, Marco; Prandi, Adolfo; Randazzo, Pietro; Ronzoni, Silvano; Sinisi, Roberta; Seneci, Pierfausto; Summa, Vincenzo; Gallo, Mariana; Veneziano, Maria; Cellucci, Antonella; Mazzocchi, Nausicaa; Menegon, Andrea; Di Fabio, Romano researched the compound: 6-Fluoronicotinonitrile( cas:3939-12-6 ).Recommanded Product: 6-Fluoronicotinonitrile.They published the article 《Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS》 about this compound( cas:3939-12-6 ) in ACS Medicinal Chemistry Letters. Keywords: acid sensing ion channel inhibitor CNS. We’ll tell you more about this compound (cas:3939-12-6).
Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chem. starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound I is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.
Although many compounds look similar to this compound(3939-12-6)Recommanded Product: 6-Fluoronicotinonitrile, numerous studies have shown that this compound(SMILES:N#CC1=CC=C(F)N=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem