Category: benzofurans

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides.Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides was described. The asym. reduction of Et γ-chloroacetoacetate catalyzed by chiral oxazaborolidines enantioselectively gave Et R-3-hydroxy-4-chlorobutyrate in good yield and enantioselectivity. In following two steps, such an ester was converted into L-carnitine hydrochloride in 68.3% overall yield with 94.6% ee and acetyl-L-carnitine hydrochloride in 62.6% overall yield with 96.8% ee. Some factors effecting the yield and the enantioselectivity of asym. reduction of Et γ-chloroacetoacetate were investigated.

《Enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Study of pharmaceutical availability of phenylbutazone and its sodium salt from selected suppository bases., the main research direction is phenylbutazone sodium release suppository.SDS of cas: 129-18-0.

Phenylbutazone Na [129-18-0] was released 2-10 times more rapidly than phenylbutazone [50-33-9] from suppositories, the exact ratio depending on the base. The former was also more stable in suppository formulations. The most rapid release was obtained from cocoa butter and Witepsol H 15.

《Study of pharmaceutical availability of phenylbutazone and its sodium salt from selected suppository bases.》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)SDS of cas: 129-18-0.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Immobilization of perfluoroalkylated enzymes in a biologically active state onto Perflex support, published in 1991-10-31, which mentions a compound: 70539-42-3, mainly applied to Perflex perfluoroalkylated enzyme immobilization, Category: benzofurans.

Perflex was introduced as a new fluorocarbon-based technol. for protein immobilization. Due to the hydrophobic character of the support, however, significant loss of enzymic activity may occur upon immobilization of certain enzymes, which appears to be due to a large conformational change of the protein (inversion). Pretreatment of the Perflex support with a neutral fluorosurfactant lessened the surface hydrophobicity, thus decreasing the hydrophobic interaction between the support and the protein. Modification of enzymes with a high number of fluorocarbon residues, which forms a hydrophobic envelope around the protein, also appeared to prevent enzyme inactivation upon immobilization on Perflex support. Moreover, preactivation of the support with either perfluorooctylpropylisocyanate or reactive poly(fluoroalkyl)sugar reagents greatly improved the enzyme particle activity by increasing the amount of immobilized enzyme. Fluorosurfactant treatment of the support activated with perfluorooctylpropylisocyanate improved the retention of activity for sensitive enzymes such as chymotrypsin and increased the wet ability and ease of handling of the Perflex particles.

《Immobilization of perfluoroalkylated enzymes in a biologically active state onto Perflex support》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fitzgerald, T. J.; Williams, Betsy; Uyeki, E. M. published the article 《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》. Keywords: antimitotic paw swelling; antiinflammatory agent edema; colchicine antimitotic.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).COA of Formula: C19H19N2NaO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

The antimitotics colchicine (I) [64-86-8] (2 mg/kg), vinblastin [865-21-4] (8 mg/kg), vincristine [57-22-7] (1 mg/kg), and podophyllotoxin [518-28-5] (2 or 10 mg/kg) produced in mice a significant suppression of paw swelling at similar dose levels. Deacetamidocolchicine [1420-08-2], a more potent antimitotic agent than I, was less active against paw swelling even when given in a 58-fold greater dose. The antiinflammatory agents prednisone [53-03-2] (12 mg/kg) and indomethacin [53-86-1] (20 mg/kg) inhibited paw swelling but phenylbutazone [50-33-9] (250 mg/kg), even at lethal doses, was inactive in this respect.

《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)COA of Formula: C19H19N2NaO2.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 90866-33-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Total synthesis of (+)-negamycin and its 5-epi-derivative. Author is Nishiguchi, Shigenobu; Sydnes, Magne O.; Taguchi, Akihiro; Regnier, Thomas; Kajimoto, Tetsuya; Node, Manabu; Yamazaki, Yuri; Yakushiji, Fumika; Kiso, Yoshiaki; Hayashi, Yoshio.

(+)-Negamycin was prepared in 13 steps in an overall yield of 31% from com. available Et (R)-(+)-4-chloro-3-hydroxybutanoate. The key step in the reaction sequence was a highly stereoselective Michael addition of chiral amine (1S,2R)-(-)-2-methoxybornyl-10-benzylamine (I) into the α,β-unsaturated ester II to give adduct III, thus establishing the second chiral center in (+)-negamycin. 5-Epi-Negamycin was also prepared in a similar fashion.

《Total synthesis of (+)-negamycin and its 5-epi-derivative》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Recommanded Product: 90866-33-4.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Age-dependence of succinate dehydrogenase (SDH) in rat liver and its inducibility after barbital and phenylbutazone pretreatment. Author is Barth, A.; Klinger, W..

The succinate dehydrogenase [9002-02-2] activity of rat liver homogenates increased 3-fold from 1 day before to 1 day after birth. Treatment for 3 days with barbital Na (I) [144-02-5] (150 mg/kg, i.p.) or phenylbutazone Na (II Na) [129-18-0] (50 or 100 mg/kg, i.p.) had no effect on the enzyme activity of rats aged 8, 30, 60, or 240 days.

《Age-dependence of succinate dehydrogenase (SDH) in rat liver and its inducibility after barbital and phenylbutazone pretreatment》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Application of 129-18-0.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Congo red interaction with alpha-proteins.》. Authors are Sereikaite, Jolanta; Bumelis, Vladas-Algirdas.The article about the compound:Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinatecas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O).Formula: C18H20N2O12. Through the article, more information about this compound (cas:70539-42-3) is conveyed.

The ability of Congo red to form complexes with alpha-proteins, human growth hormone and human interferon-alpha2b, was found by absorption difference spectroscopy. A human growth hormone-Congo red complex was isolated by gel-permeation chromatography, and its visible absorption spectrum was registered in comparison to free dye. The ability of Congo red to induce dimerization of human growth hormone was demonstrated using chemical cross-linking agents 1,3,5-triacryloyl-hexahydro-s-triazine and ethylene glycol bis(succinimidylsuccinate).

《Congo red interaction with alpha-proteins.》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Formula: C18H20N2O12.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Cloning, expression, and characterization of an (R)-specific alcohol dehydrogenase from Lactobacillus kefir. Author is Weckbecker, Andrea; Hummel, Werner.

Lactobacillus kefir DSM 20587 produces an (R)-specific NADP-dependent alc. dehydrogenase (ADH) with a broad substrate specificity. The gene of this ADH was isolated and the complete nucleotide sequence determined The adh gene comprises 759 bp and encodes a protein of 252 amino acids with a calculated mol. weight of 26 781 Da. The deduced amino acid sequence indicated a high degree of similarity to short-chain dehydrogenases. After cloning and expression in Escherichia coli the enzyme was purified and characterized. For the reduction of acetophenone the specific activity of the homogeneous recombinant ADH was 558 U mg-1. The enzyme shows its maximum activity at 50°C while the pH optimum was at pH 7.0. In order to demonstrate its preparative application, purified ADH was used for the stereoselective reduction of several aliphatic and aromatic ketones as well as β-keto esters. Glucose dehydrogenase was added for the regeneration of NADPH. All prochiral ketones were stereoselectively reduced to the corresponding alcs. with >99% ee and in the case of diketones >99% de.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C6H11ClO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about How cell physiology affects enantioselectivity of the biotransformation of ethyl 4-chloro-acetoacetate with Saccharomyces cerevisiae. Author is Bertau, M..

Saccharomyces cerevisiae (baker’s yeast) reduces Et 4-chloro-acetoacetate enantioselectively to (R)- or (S)-Et 4-chloro-3-hydroxybutyrate depending on the reaction conditions and the physiol. state of the yeast cells. The (S)-enantiomer is obtained under batch conditions with resting cells (55%, enantiomeric excess [ee]), and 4-chloro-acetate fed-batch actively metabolizing yeast affords the (R)-isomer (54%, ee). The enantioselective reduction of the substrate is accompanied by competing enzyme actions. Of the metabolites formed from the substrate, chloroacetone and the target compound (R)-Et 4-chloro-3-hydroxybutyrate emerged as most important effectors of enantioselectivity of the microbial reduction As a minor side-reaction, an aerobic reductive dehalogenation of the substrate was observed The unusual high enantiopurity of the dehalo-product (S)-Et 3-hydroxybutyrate confirms the stereo-directing effect of chloroacetone impressively. Hence, with S. cerevisiae either enantiomer can be obtained by variation of reaction conditions. The yeast further turned out to be a promising biocatalyst for dehalogenations.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)COA of Formula: C6H11ClO3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cuellar, Elena; Pastor, Laura; Garcia-Herbosa, Gabriel; Nganga, John; Angeles-Boza, Alfredo M.; Diez-Varga, Alberto; Torroba, Tomas; Martin-Alvarez, Jose M.; Miguel, Daniel; Villafane, Fernando published the article 《(1,2-Azole)bis(bipyridyl)ruthenium(II) Complexes: Electrochemistry, Luminescent Properties, And Electro- And Photocatalysts for CO2 Reduction》. Keywords: ruthenium azole bipyridyl complex preparation electrochem luminescence photocatalyst; crystal structure ruthenium azole bipyridyl complex.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Product Details of 2923-28-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

New cis-(1,2-azole)-aquo bis(2,2′-bipyridyl)ruthenium(II) (1,2-azole (az*H) = pzH (pyrazole), dmpzH (3,5-dimethylpyrazole), and indzH (indazole)) complexes are synthesized via chlorido abstraction from cis-[Ru(bipy)2Cl(az*H)]OTf. The latter are obtained from cis-[Ru(bipy)2Cl2] after the subsequent coordination of the 1,2-azole. All the compounds are characterized by 1H, 13C, 15N NMR spectroscopy as well as IR spectroscopy. Two chlorido complexes (pzH and indzH) and two aquo complexes (indzH and dmpzH) are also characterized by X-ray diffraction. Photophys. and electrochem. studies were carried out on all the complexes. The photophys. data support the phosphorescence of the complexes. The electrochem. behavior of all the complexes in an Ar atm. indicate that the oxidation processes assigned to Ru(II) → Ru(III) occurs at higher potentials in the aquo complexes. The reduction processes under Ar lead to several waves, indicating that the complexes undergo successive electron-transfer reductions that are centered in the bipy ligands. The first electron reduction is reversible. The electrochem. behavior in CO2 media is consistent with CO2 electrocatalyzed reduction, where the values of the catalytic activity [icat(CO2)/ip(Ar)] ranged from 2.9 to 10.8. Controlled potential electrolysis of the chlorido and aquo complexes affords CO and formic acid, with the latter as the major product after 2 h. Photocatalytic experiments in MeCN with [Ru(bipy)3]Cl2 as the photosensitizer and TEOA as the electron donor, which were irradiated with >300 nm light for 24 h, led to CO and HCOOH as the main reduction products, achieving a combined turnover number (TONCO+HCOO-) as high as 107 for 2c after 24 h of irradiation

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)Product Details of 2923-28-6 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem