Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides.Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate.
The enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides was described. The asym. reduction of Et γ-chloroacetoacetate catalyzed by chiral oxazaborolidines enantioselectively gave Et R-3-hydroxy-4-chlorobutyrate in good yield and enantioselectivity. In following two steps, such an ester was converted into L-carnitine hydrochloride in 68.3% overall yield with 94.6% ee and acetyl-L-carnitine hydrochloride in 62.6% overall yield with 96.8% ee. Some factors effecting the yield and the enantioselectivity of asym. reduction of Et γ-chloroacetoacetate were investigated.
《Enantioselective synthesis of L-carnitine and acetyl-L-carnitine hydrochlorides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem