In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Immobilization of perfluoroalkylated enzymes in a biologically active state onto Perflex support, published in 1991-10-31, which mentions a compound: 70539-42-3, mainly applied to Perflex perfluoroalkylated enzyme immobilization, Category: benzofurans.
Perflex was introduced as a new fluorocarbon-based technol. for protein immobilization. Due to the hydrophobic character of the support, however, significant loss of enzymic activity may occur upon immobilization of certain enzymes, which appears to be due to a large conformational change of the protein (inversion). Pretreatment of the Perflex support with a neutral fluorosurfactant lessened the surface hydrophobicity, thus decreasing the hydrophobic interaction between the support and the protein. Modification of enzymes with a high number of fluorocarbon residues, which forms a hydrophobic envelope around the protein, also appeared to prevent enzyme inactivation upon immobilization on Perflex support. Moreover, preactivation of the support with either perfluorooctylpropylisocyanate or reactive poly(fluoroalkyl)sugar reagents greatly improved the enzyme particle activity by increasing the amount of immobilized enzyme. Fluorosurfactant treatment of the support activated with perfluorooctylpropylisocyanate improved the retention of activity for sensitive enzymes such as chymotrypsin and increased the wet ability and ease of handling of the Perflex particles.
《Immobilization of perfluoroalkylated enzymes in a biologically active state onto Perflex support》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Category: benzofurans.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem