Recommanded Product: 90866-33-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Total synthesis of (+)-negamycin and its 5-epi-derivative. Author is Nishiguchi, Shigenobu; Sydnes, Magne O.; Taguchi, Akihiro; Regnier, Thomas; Kajimoto, Tetsuya; Node, Manabu; Yamazaki, Yuri; Yakushiji, Fumika; Kiso, Yoshiaki; Hayashi, Yoshio.
(+)-Negamycin was prepared in 13 steps in an overall yield of 31% from com. available Et (R)-(+)-4-chloro-3-hydroxybutanoate. The key step in the reaction sequence was a highly stereoselective Michael addition of chiral amine (1S,2R)-(-)-2-methoxybornyl-10-benzylamine (I) into the α,β-unsaturated ester II to give adduct III, thus establishing the second chiral center in (+)-negamycin. 5-Epi-Negamycin was also prepared in a similar fashion.
《Total synthesis of (+)-negamycin and its 5-epi-derivative》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Recommanded Product: 90866-33-4.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem