Category: 129-18-0

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat, published in 1981-09-30, which mentions a compound: 129-18-0, mainly applied to phenylbutazone stomach ulcer mechanism, Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The nonsteroid anti-inflammatory drugs including phenylbutazone produce significant gastric ulceration and hemorrhage even when administered by an extragastric route. To investigate the mechanism involved, cervical sectioned rats received an intraileal injection of phenylbutazone Na (I Na) [129-18-0] in methylcellulose. Gastric contractile activity was recorded with a miniature gastric balloon, and the stomach was perfused with either acid at pH 1 or buffer at pH 7. Rats receiving I developed a pattern of abnormally strong contractile activity that began 60-90 min after drug administration. The contracting stomachs of rats perfused with acid developed more ulceration and bled more severely than buffer-perfused rats. Vagotomy or atropine prevented the gastric contractile response to I, and such rats failed to develop significant ulceration in spite of the fact that their stomachs were perfused with acid. Cervical sectioned rats treated with methylcellulose alone failed to develop the abnormal contractile pattern and showed no significant gastric injury or hemorrhage. Thus, the focal hemorrhagic lesions induced by the extragastric administration of I in the rat are the result of mucosal compression at specific sites secondary to the passage of extremely strong peristaltic waves. They are vagally mediated and although the presence of acid does not appear essential for their initiation, it plays a synergistic role in their development and hemorrhage.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Sequence of release of neurohormones on nervous stimulation of frog’s stomach muscle》. Authors are Singh, I..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).COA of Formula: C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The experiments were performed on the stomach muscle of Rana tigrina. The nerve-muscle preparations were made as described by S., et al. (CA 56, 9285e), and were immersed in saline, or in 0.112M sucrose. The contraction produced by nerve stimulation showed seasonal variations. In summer (room temperature 29-31°), the latent period of response was 2-5 sec., and in winter (room temperature 23-5°), the latent period was 20-50 sec. In winter and in summer, atropine sulfate (I) did not abolish the contraction, unless it was previously treated with 2-bromo-D-lysergic acid diethylamide (II). Neopyramine (III) did not abolish the contraction of untreated muscles, but it abolished the contraction of muscles treated with I and II. The effects of II are different in summer and in winter. In winter, the contraction were diminished or abolished. In summer, the contractions were enhanced, but if the muscles were soaked in sucrose solution, the effect in summer was similar to that in winter. A combination of I, II, and III did not affect, or slightly diminished contractions in summer and in winter. If the muscle is soaked in sucrose, the contraction persists, indicating a release of substance P. Substance P itself caused contraction in sucrose-soaked muscles. As in winter, nervous stimulation in summer also produced relaxation, which was abolished by II the relaxation produced by adrenaline or noradrenaline was not affected.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Bulletin of the Faculty of Pharmacy (Cairo University) called Formulation and stabilization of phenylbutazone sodium injectable solution, Author is Kassem, Aly Aly; Abd El-Bary, Ahmed, the main research direction is phenylbutazone sodium injection stabilization.Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The most appropriate pH for phenylbutazone sodium solutions is 8.2. Sterilization at 100° for 30 min in the presence of 0.2% chlorocresol is the most satisfactory. Light has a deleterious effect on this solution The stability of the product improves in the presence of propylene glycol,sodium metabisulfite and diethylenetriaminepentaacetic acid. The use of the antioxidant and the complexing agent in combination gave better results than the use of either of these alone.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《N-[5-(2-Methoxyethoxy)-2-pyrimidinyl] benzenesulfonamide (glycodiazine). V. Effect of phenylethylbarbituric acid on the metabolism and hypoglycemic effect of glycodiazine in vitro and vivo》. Authors are Gerhards, E.; Kolb, K. H.; Schulze, P. E..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

cf. CA 64, 18224g. The metabolism of glycodiazine, 2-benzenesulfonamido-5-(βhydroxyethoxy)diazine (II), and tolbutamide after Luminal treatment was studied in the rat, dog, and in man. The 20,000 g liver supernatant from untreated rats metabolized 25% of the glycodiazine and tolbutamide in vitro, whereas that fraction from rats treated with Luminal (2 × 5 mg./100 g. body weight/ day for 3 days intraperitoneally) metabolized 60-70% of the drugs. The formation of 2-benzenesulfonamido-5-(carboxymethoxy)diazine from II was increased from 2% with liver fractions from untreated rats to 8% with that from Luminal-treated rats. After oral administration of glycodiazine-3H to untreated rats, 35% of the radioactivity was excreted in the urine within the 1st 4 hrs., whereas Luminal-treated rats excreted 65%. Pretreatment of dogs with Luminal (10 mg./kg./ day for 7 days orally) increased the urinary excretion of 3H following oral administration of 900 mg. of glycodiazine-3H 1.6-fold within 12 hrs., compared with nonpretreated controls. Luminal did reduce the concentration of glycodiazine in the blood, however. In man, pretreatment with Luminal reduced the level of glycodiazine about 2-fold when compared with controls. Luminal did not affect the hypoglycemic effect of glycodiazine in rats, dogs, or humans, indicating that the former has no effect on the influence of the latter on insulin secretion. 23 references.

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Related Products of 129-18-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacological properties of butazolidine and of its calcium and sodium salts. Author is Wilhelmi, G..

The antiinflammatory effect of butazolidine Ca (I) was compared with that of butazolidine (II) and of its Na salt (III). I had a less potent effect than II or III against formalin peritonitis in the rat and ultraviolet erythema in the guinea pig. It showed a potency equal to II and III against formalin edema in the rat and croton oil inflammation in the mouse ear. I was more effective than II or III with respect to inhibition of exudation in the granuloma pouch.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Rev. Rhumat. called Action of antirheumatic drugs on the rheumatoid arthritic serum factors (hemagglutinating factor, the latex-agglutinating factors 1 and 2, and the streptococcal agglutinating factor), Author is Seifert, H., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The specific destruction of so-called rheumatoid factor is suggested as the cause of the lowering of the titers of the Waaler-Rose test, the latex-fixation test, and streptococcal-agglutinating test, frequently observed during antirheumatic therapy. The concept of a rheumatoid factor is abandoned in favor of 4 factors isolated from the serum of patients with rheumatoid arthritis: hemagglutinating factor; latex-agglutinating factor LF1; latex agglutinating factor LF2 (which agglutinates only particles of latex pretreated with human γ-globulin); and streptococcal-agglutinating factor. Earlier studies showed that each of these 4 factors consists of an a (agglutinating) fraction and a p (precipitating) fraction. These factors were treated in vitro with antirheumatic drugs for 5 hrs. to demonstrate their lability. The greatest destructive effect was produced by hydrocortisone. Approx. 6-8 mg. sufficed to destroy 1 mg. of factor. Using this procedure, the factor-destroying capacity of known antirheumatic drugs can be determined and other possible agents can be screened. Whether the factor-destroying capacity in each case parallels antirheumatic potency requires further investigation.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Imamura, Yorishige; Shigemori, Keiko; Ichibagase, Hisashi researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Effects of simultaneous administration of drugs on absorption and excretion. V. Effect of phenylbutazone on antibacterial activity and distribution of sulfadimethoxine in rabbits》 about this compound( cas:129-18-0 ) in Chemical & Pharmaceutical Bulletin. Keywords: sulfadimethoxine bactericide pharmacokinetics phenylbutazone; sulfanilamide pharmacokinetics phenylbutazone; salicylate sulfanilamide pharmacokinetics. We’ll tell you more about this compound (cas:129-18-0).

The antibacterial activities of sulfadimethoxine [122-11-2] (25 mg/kg, i.v.) in rabbit plasma were significantly increased by concomitant injection of Na phenylbutazone (Na I) [129-18-0] (50 mg/kg, i.v.). The levels of unchanged sulfadimethoxine in rabbit plasma were significantly reduced by concomitant injection of phenylbutazone. These results suggest that phenylbutazone increases the transfer of sulfadimethoxine from plasma to tissues in rabbits.

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Benzofuran – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Testing of the antiphlogistic effect of antirheumatic drugs》. Authors are Seidel, K.; Eckstein, M..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Various anti-rheumatic drugs were measured for their antiphlogistic activity on human skin erythemas induced by uv light. Prednisone (30 mg. per os, daily), wofapyrine (1.5 g./day, i.m.), nicopyrone (1.5 g.) plus metamizol (1.5 g.) (1 tablet daily), nicopyrone (1.2 g.) plus prednisone (9.0 mg.) (1 tablet daily), and nicopyrone (1.2 g.) plus prednisone (4.5 mg.) (1 tablet daily), all for 4 days, reduced the skin inflammation inducible by uv light by 42.8, 41.1, 41.4, 46.2, and 43.6%, resp. 16 references

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Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Leukocyte migration inhibition test on agarose – a rational test method for cell-mediated immune reactivity. Author is Emmrich, F..

The agarose plate leukocyte migration inhibition test of J. E. Clausens (1973) was used to detect iatrogenic allergy in skin-test pos. patients. Plates were prepared from 0.9% agarose, and patients’ leukocyte migration response to drugs (antigens) determined after 1hr incubation at 37°. Thus, 10-50 mg/mL PPD gave 1.0-0.8 migration inhibition index with leukocytes from skin-tes pos., active tuberculosis patients. Similar results were obtained with patients allergic to nitrazepam, sulfamerazine, and phenylbutazone. It is concluded that the this agarose method may be used to detect cellular hypersensitivity.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Actions of 5-(1,3-dimethylbutyl)-5-ethylbarbituric acid, pentobarbital, amobarbital and thiopental on the sinoatrial nodal activity of the isolated heart》. Authors are Schaer, Hansjuerg.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Related Products of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The convulsant barbiturate, Na 5-(1,3-dimethylbutyl)-5-ethyl barbiturate (DMBEB) exerts a dual action on isolated spontaneously beating guinea pig atria suspended in Krebs-Henseleit solution at 37°. At concentrations from 0.001 to 0.01 mg./ml., it has predominantly a transient rate-increasing effect, whereas at higher concentrations, an addnl. neg. chronotropic action appears. Experiments with atria of reserpine-pretreated guinea pigs (3 mg./kg., 24 hrs.) and experiments with β-receptor blockade have shown that the rate-increasing effect of DMBEB is not mediated by released norepinephrine and the DMBEB probably has no direct action on adrenergic β-receptors. Na pentobarbital and Na amobarbital, though structurally related to DMBEB, exhibit exclusively a neg. chronotropic action. Their neg. chronotropic effect is identical; it occurs in the same concentration range in which DMBEB manifests its rate-decreasing effect on the sino-atrial node. Na thiopental is more potent in its rate-decreasing effect than are Na pentobarbital and Na amobarbital.

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