In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat, published in 1981-09-30, which mentions a compound: 129-18-0, mainly applied to phenylbutazone stomach ulcer mechanism, Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.
The nonsteroid anti-inflammatory drugs including phenylbutazone produce significant gastric ulceration and hemorrhage even when administered by an extragastric route. To investigate the mechanism involved, cervical sectioned rats received an intraileal injection of phenylbutazone Na (I Na) [129-18-0] in methylcellulose. Gastric contractile activity was recorded with a miniature gastric balloon, and the stomach was perfused with either acid at pH 1 or buffer at pH 7. Rats receiving I developed a pattern of abnormally strong contractile activity that began 60-90 min after drug administration. The contracting stomachs of rats perfused with acid developed more ulceration and bled more severely than buffer-perfused rats. Vagotomy or atropine prevented the gastric contractile response to I, and such rats failed to develop significant ulceration in spite of the fact that their stomachs were perfused with acid. Cervical sectioned rats treated with methylcellulose alone failed to develop the abnormal contractile pattern and showed no significant gastric injury or hemorrhage. Thus, the focal hemorrhagic lesions induced by the extragastric administration of I in the rat are the result of mucosal compression at specific sites secondary to the passage of extremely strong peristaltic waves. They are vagally mediated and although the presence of acid does not appear essential for their initiation, it plays a synergistic role in their development and hemorrhage.
Here is a brief introduction to this compound(129-18-0)Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, if you want to know about other compounds related to this compound(129-18-0), you can read my other articles.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem