The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Actions of 5-(1,3-dimethylbutyl)-5-ethylbarbituric acid, pentobarbital, amobarbital and thiopental on the sinoatrial nodal activity of the isolated heart》. Authors are Schaer, Hansjuerg.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Related Products of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.
The convulsant barbiturate, Na 5-(1,3-dimethylbutyl)-5-ethyl barbiturate (DMBEB) exerts a dual action on isolated spontaneously beating guinea pig atria suspended in Krebs-Henseleit solution at 37°. At concentrations from 0.001 to 0.01 mg./ml., it has predominantly a transient rate-increasing effect, whereas at higher concentrations, an addnl. neg. chronotropic action appears. Experiments with atria of reserpine-pretreated guinea pigs (3 mg./kg., 24 hrs.) and experiments with β-receptor blockade have shown that the rate-increasing effect of DMBEB is not mediated by released norepinephrine and the DMBEB probably has no direct action on adrenergic β-receptors. Na pentobarbital and Na amobarbital, though structurally related to DMBEB, exhibit exclusively a neg. chronotropic action. Their neg. chronotropic effect is identical; it occurs in the same concentration range in which DMBEB manifests its rate-decreasing effect on the sino-atrial node. Na thiopental is more potent in its rate-decreasing effect than are Na pentobarbital and Na amobarbital.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem