Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Rev. Rhumat. called Action of antirheumatic drugs on the rheumatoid arthritic serum factors (hemagglutinating factor, the latex-agglutinating factors 1 and 2, and the streptococcal agglutinating factor), Author is Seifert, H., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.
The specific destruction of so-called rheumatoid factor is suggested as the cause of the lowering of the titers of the Waaler-Rose test, the latex-fixation test, and streptococcal-agglutinating test, frequently observed during antirheumatic therapy. The concept of a rheumatoid factor is abandoned in favor of 4 factors isolated from the serum of patients with rheumatoid arthritis: hemagglutinating factor; latex-agglutinating factor LF1; latex agglutinating factor LF2 (which agglutinates only particles of latex pretreated with human γ-globulin); and streptococcal-agglutinating factor. Earlier studies showed that each of these 4 factors consists of an a (agglutinating) fraction and a p (precipitating) fraction. These factors were treated in vitro with antirheumatic drugs for 5 hrs. to demonstrate their lability. The greatest destructive effect was produced by hydrocortisone. Approx. 6-8 mg. sufficed to destroy 1 mg. of factor. Using this procedure, the factor-destroying capacity of known antirheumatic drugs can be determined and other possible agents can be screened. Whether the factor-destroying capacity in each case parallels antirheumatic potency requires further investigation.
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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem