Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Separation of ethyl (R) 4-chloro-3-hydroxybutyrate from racemic mixture by using bulk liquid membrane.
The separation of optically active Et (R) 4-chloro-3-hydroxybutyrate (CHBE), which is precursor of L-carnitine, from its racemic mixture was studied. Bulk liquid membrane was used as a separation method. Racemic mixture was prepared by mixing each pure enantiomers. Carrier material that facilitates transport of CHBE was dissolved in membrane phase and cinchonidine, cyclodextrin were used as carriers. Carrier concentration, pH gradient, salt addition varied during experiment as exptl. parameters. CHBE transported from feed phase to receiving through the membrane phase, but the enantioselectivity was still in low range. Through whole experiment, proper selection of membrane phase and carrier was key factors that affected CHBE separation
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem