Category: 129-18-0

Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonism by antiinflammatory analgesics of prostaglandin F2α-induced contractions of human and rabbit myometrium in vitro. Author is Smith, Ian D.; Temple, Diana M.; Shearman, Rodney P..

In isolated human pregnant myometrial strips or isolated rabbit nonpregnant myometrium, the antiinflammatory analgesic drugs aspirin [50-78-2], Na indomethacin [7681-54-1], Na phenylbutazone (I-Na salt) [129-18-0], Na mefenamate [1804-47-3], Na ibuprofen [31121-93-4], and Na flurbiprofen [56767-76-1] inhibited in a dose-dependent manner the force of contraction stimulated by adding PGF2α (II) [551-11-1] to the tissue bath. In addition to these drugs, Na flufenamate [1977-00-0] and salicin [138-52-3] showed a similar antagonism of the action of II in the rabbit nonpregnant tissue. The ratio of the inhibitory concentration in vitro suggests that I and possibly ibuprofen may be capable of inhibiting human uterine contractions in vivo. Patients who were treated with aspirin during induction of abortion using II during the 2nd trimester of pregnancy showed no significant change in the induction-abortion interval compared with patients not taking aspirin.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide(SMILESS: O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+],cas:129-18-0) is researched.Related Products of 1265884-98-7. The article 《Influence of various drugs on the tissue permeability. II》 in relation to this compound, is published in Nippon Yakurigaku Zasshi. Let’s take a look at the latest research on this compound (cas:129-18-0).

The effects of drugs containing antiinflammatory agents administrated systemically on the dermal connective tissue permeability in rats were tested by a spreading method based on the rate of diffusion of Evans blue solution after intradermal injection. Antiinflammatory agents decreased the tissue permeability following s.c. and oral administration. In most cases, there were dose-response relations. Intensity of the inhibitory effect of the tissue permeability was in the order: dexamethasone, indometacin (I), prednisolone, phosphate, Na bucolome (II), hydrocortisone acetate (III), Na, phenylbutazone, flufenamic acid, N-(o-methoxybenzoyl)glycine dimethylamide, benzydamine-HCl (IV), 4-chloro-5-sulfamoyl-anthranilic acid, mefenamic acid, aminopyrine (V), acetylsalicylic acid (VI), Na salicylate (VII), pronase AS, and bromelain. When II, III, V, and VII were combined with l-ascorbic acid their inhibitory effects were enhanced in both s.c. and oral administration, while the inhibitory effect in oral administration of I, IV, and VI was enhanced.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Objective and timing of drug disposition studies. IV. Phenylbutazone formulations. In vitro dissolution and in vivo performance.

GP 26872 [129-18-0] (a glycerin solution of phenylbutazone Na salt) produced a more rapid onset of plasma levels of phenylbutazone (I) [50-33-9] as well as higher maximum concentration than pure I but the amount of drug absorbed was not significantly different. The dissolution rate of capsules was in the following decreasing order: pure GP 26872 > pure I > formulated I > formulated GP 26872. A film coated I tablet gave an average plasma level of ∼15 μg/ml in 30 min, whereas with a sugar coated tablet these peak levels were not attained until 3 hr. Peak levels were 34 and 57 μg/ml with the film coated tablet and 19 and 32 μg/ml with the sugar coated tablet. I was pure I in capsules.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacological studies of tectoridin and tectorigenin. Author is Esaki, Shunji.

Tectoridin (I) and tectorigenin (II) were observed to be hyaluronidase inhibitory both in vitro and in vivo. The hyaluronidase inhibition in vitro was not reversed with cysteine, in contrast to that with rutin (III) and quercetin (IV). The nonsteroidal, antiinflammatory drugs, 5-butyl-1-cyclohexyl-2,4,6-trioxo-perhydropyrimidine Na and phenylbutazone Na, were observed to have hyaluronidase inhibitory activity in vivo but not in vitro. The hyaluronidase edema in rat hind paw was inhibited with I and II but not the carrageenin edema. The exudation of ascites induced in rats by mustard was slightly inhibited with I and II. The stretching induced by HOAc and the permeability of dye into the peritoneum was inhibited by I and II but not so markedly as by IV. It was considered that I and II have weak estrogenlike action. The acute toxicity of I and II was very weak, almost the same as III and IV.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Comparison of pharmacology of various salts of phenylbutazone and the simultaneous administration of L-ascorbic acid》. Authors are Wilhelmi, G..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Na, K, Li, Ca, Mg, Sr, dimethylaminoethanol, and diethylaminoethanol salts of phenylbutazone showed in mice an equal toxicity and ulcer-causing effect in the stomach and an equal potency in inhibiting erythema and fever at high dosage. In formalin edema and peritonitis in mice the Na salt had a strong antiinflammatory action, almost as strong as the Ca salt. In the production of analgesia in mice the Na salt and the dimethylaminoethanol salt were most effective, while those of bivalent metals were less active. The subcutaneous administration of L-ascorbic acid lessened the antiinflammatory and analgesic effects and to some degree the toxicity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Fibrinolytic activity of antiinflammatory drugs》. Authors are Gryglewski, R..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The fibrinolytic activity of antiinflammatory drugs was studied in vitro by incubating them with human plasma clots. Na salicylate, Na acetylsalicylate, and Na amidopyrine exhibited trace fibrinolytic activity, while Na phenylbutazone, Na mefenamate, and Na flufenamate showed full fibrinolytic activity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Chemical characterization of the products of drug decomposition. IV. Mechanism of phenylbutazone decomposition in pharmaceutical preparations.HPLC of Formula: 129-18-0.

Injections of phenylbutazone (I) sodium were analyzed by various chromatographic techniques. The decomposition products detected were 4-butyl-4-hydroxy-1,2-diphenylpyrazolidine-3,5-dione (II), PhN(NHPh)COCHBuCO2H (III), trans- and cis-PhN:NPh, and BuCH(CO2H)2. A similar anal. of overdue suppositories containing I revealed the presence of II, III, PhN(NHPh)COC5H11, and PhN(NHPh)CBu(OH)CO2H. (m. 148°). Hydrolytic decomposition was predominant in injections, and oxidative decomposition, in suppositories.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C19H19N2NaO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Influence of nonsteroid antiinflammatory and immunosuppressive drugs on hepatic tryptophan pyrrolase activity in rats. Author is Reinicke, Claus; Guttmacher, Hansjuergen; Ulbricht, Wolfgang.

Orally administered indomethacin [53-86-1] (3 mg/kg), sodium salicylate [54-21-7] (120 mg/kg), acetylsalicylic acid [50-78-2] (300 mg/kg), salicylamide [65-45-2] (160 mg/kg), mefenamic acid [61-68-7] (340 mg/kg), flufenamic acid (I) [530-78-9] (90 mg/kg), amidopyrine [58-15-1] (340 mg/kg), sodium phenylbutazone [129-18-0] (50 mg/kg), and benzydamine-HCl [132-69-4] (200 mg/kg) administered repeatedly did not alter tryptophan pyrrolase [9014-51-1] activity in the liver of intact rats. Orally administerd I increased tyrosine aminotransferase [9014-55-5] activity. Of the nonsteroidal inflammation inhibitors tested, only I and benzydamine blocked the induction of tryptophan pyrrolase by cortisol [50-23-7]. Orally administered cyclophosphamide [50-18-0] (140 mg/kg), triaziquone [68-76-8] (0.45 mg/kg), and azathioprine [446-86-6] increased tryptophan pyrrolase activity, whereas chloroquine diphosphate [50-63-5] (20 mg/kg), 6-mercaptopurine [50-44-2] (75 mg/kg), 6-azauridine [54-25-1] (100 mg/kg), and amethopterin [59-05-2] (2 mg/kg) did not. Induction of tryptophan pyrrolase by cortisol was blocked by azathioprine, 6-mercaptopurine, 6-azauridine, and amethopterin. Enzyme induction is not an essential property of nonsteroidal inflammation inhibitors.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Rectal delivery of antiinflammatory drugs. I. The influence of antiinflammatory drugs on rectal absorption of β-lactam antibiotics. Author is Yaginuma, Hideya; Nakata, Tohru; Toya, Harumasa; Murakami, Teruo; Yamazaki, Masaru; Kamada, Akira.

The effects of non-steroid antiinflammatory (NSAI) drugs on the rectal membrane were studied by measuring the change in the rectal absorption of ampicillin Na  [69-52-3] and cephalothin  [153-61-7]. All the NSAI drugs studied caused a remarkable enhancement of the rectal absorption of antibiotics which were not able to permeate readily through the rectal membrane in the absence of NSAI drugs. The optimum concentrations of NSAI drugs as adjuvants in triglyceride suppositories containing 10% ampicillin Na were 1.5% for indomethacin Na  [7681-54-1] and diclofenac Na  [15307-79-6], 5% for mepirizole  [18694-40-1], 7.5% for phenylbutazone  [50-33-9], and 10% for Na salicylate  [54-21-7]. These concentrations of NSAI drugs were used in a study of the promoting efficacy of the drugs as adjuvants for the rectal absorption of antibiotics. The promoting effects of adjuvants in dogs were inferior to those in rabbits. From simultaneous measurements of NSAI drugs and antibiotic, it was found that the absorption of antibiotic started at the early stages after the administration of suppositories and the peak blood level was reached while the blood concentration of NSAI drug was still increasing. Apparently the NSAI drugs made the mucosal barrier leaky to water-soluble antibiotics at the early stages of permeation of the NSAI drugs through the rectal membrane, and the barrier rapidly recovered its normal properties even while the permeation of NSAI drug was continuing and a considerable amount of antibiotic still remained in the rectal cavity. A linear correlation between the enhanced absorption of antibiotics and the antiinflammatory activity of NSAI drugs against carrageenan-induced edema was observed

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pawelczyk, Ewaryst; Wachowiak, Roman published an article about the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+] ).Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:129-18-0) through the article.

The decomposition products formed when 20% aqueous alk. solutions of phenylbutazone Na salt were aged in sunlight were isolated and identified. The colored decomposition products were isolated by CHCl3 extraction; the colorless products were extracted with ether from the acidified solution The extracts were concentrated and separated by thin-layer chromatog. The 5 decomposition products isolated and identified with Ce(SO4)2 were (Rfvalue given) 4-hydroxyphenylbutazone (0.33), N-(2-carboxycaproyl)-hydrazobenzene (0.1), N-(2-carboxy-2-hydroxycaproyl)hydrazobenzene (0.55), trans-azobenzene (0.78), and cis-azobenzene (0.62).

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem