The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Comparison of pharmacology of various salts of phenylbutazone and the simultaneous administration of L-ascorbic acid》. Authors are Wilhelmi, G..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.
Na, K, Li, Ca, Mg, Sr, dimethylaminoethanol, and diethylaminoethanol salts of phenylbutazone showed in mice an equal toxicity and ulcer-causing effect in the stomach and an equal potency in inhibiting erythema and fever at high dosage. In formalin edema and peritonitis in mice the Na salt had a strong antiinflammatory action, almost as strong as the Ca salt. In the production of analgesia in mice the Na salt and the dimethylaminoethanol salt were most effective, while those of bivalent metals were less active. The subcutaneous administration of L-ascorbic acid lessened the antiinflammatory and analgesic effects and to some degree the toxicity.
There is still a lot of research devoted to this compound(SMILES：O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+])Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, and with the development of science, more effects of this compound(129-18-0) can be discovered.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem