Application of 129-18-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacological studies of tectoridin and tectorigenin. Author is Esaki, Shunji.
Tectoridin (I) and tectorigenin (II) were observed to be hyaluronidase inhibitory both in vitro and in vivo. The hyaluronidase inhibition in vitro was not reversed with cysteine, in contrast to that with rutin (III) and quercetin (IV). The nonsteroidal, antiinflammatory drugs, 5-butyl-1-cyclohexyl-2,4,6-trioxo-perhydropyrimidine Na and phenylbutazone Na, were observed to have hyaluronidase inhibitory activity in vivo but not in vitro. The hyaluronidase edema in rat hind paw was inhibited with I and II but not the carrageenin edema. The exudation of ascites induced in rats by mustard was slightly inhibited with I and II. The stretching induced by HOAc and the permeability of dye into the peritoneum was inhibited by I and II but not so markedly as by IV. It was considered that I and II have weak estrogenlike action. The acute toxicity of I and II was very weak, almost the same as III and IV.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem