Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Chemical characterization of the products of drug decomposition. IV. Mechanism of phenylbutazone decomposition in pharmaceutical preparations.HPLC of Formula: 129-18-0.
Injections of phenylbutazone (I) sodium were analyzed by various chromatographic techniques. The decomposition products detected were 4-butyl-4-hydroxy-1,2-diphenylpyrazolidine-3,5-dione (II), PhN(NHPh)COCHBuCO2H (III), trans- and cis-PhN:NPh, and BuCH(CO2H)2. A similar anal. of overdue suppositories containing I revealed the presence of II, III, PhN(NHPh)COC5H11, and PhN(NHPh)CBu(OH)CO2H. (m. 148°). Hydrolytic decomposition was predominant in injections, and oxidative decomposition, in suppositories.
From this literature《Chemical characterization of the products of drug decomposition. IV. Mechanism of phenylbutazone decomposition in pharmaceutical preparations》,we know some information about this compound(129-18-0)HPLC of Formula: 129-18-0, but this is not all information, there are many literatures related to this compound(129-18-0).
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem