Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonism by antiinflammatory analgesics of prostaglandin F2α-induced contractions of human and rabbit myometrium in vitro. Author is Smith, Ian D.; Temple, Diana M.; Shearman, Rodney P..
In isolated human pregnant myometrial strips or isolated rabbit nonpregnant myometrium, the antiinflammatory analgesic drugs aspirin [50-78-2], Na indomethacin [7681-54-1], Na phenylbutazone (I-Na salt) [129-18-0], Na mefenamate [1804-47-3], Na ibuprofen [31121-93-4], and Na flurbiprofen [56767-76-1] inhibited in a dose-dependent manner the force of contraction stimulated by adding PGF2α (II) [551-11-1] to the tissue bath. In addition to these drugs, Na flufenamate [1977-00-0] and salicin [138-52-3] showed a similar antagonism of the action of II in the rabbit nonpregnant tissue. The ratio of the inhibitory concentration in vitro suggests that I and possibly ibuprofen may be capable of inhibiting human uterine contractions in vivo. Patients who were treated with aspirin during induction of abortion using II during the 2nd trimester of pregnancy showed no significant change in the induction-abortion interval compared with patients not taking aspirin.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem