Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Rectal delivery of antiinflammatory drugs. I. The influence of antiinflammatory drugs on rectal absorption of β-lactam antibiotics. Author is Yaginuma, Hideya; Nakata, Tohru; Toya, Harumasa; Murakami, Teruo; Yamazaki, Masaru; Kamada, Akira.
The effects of non-steroid antiinflammatory (NSAI) drugs on the rectal membrane were studied by measuring the change in the rectal absorption of ampicillin Na [69-52-3] and cephalothin [153-61-7]. All the NSAI drugs studied caused a remarkable enhancement of the rectal absorption of antibiotics which were not able to permeate readily through the rectal membrane in the absence of NSAI drugs. The optimum concentrations of NSAI drugs as adjuvants in triglyceride suppositories containing 10% ampicillin Na were 1.5% for indomethacin Na [7681-54-1] and diclofenac Na [15307-79-6], 5% for mepirizole [18694-40-1], 7.5% for phenylbutazone [50-33-9], and 10% for Na salicylate [54-21-7]. These concentrations of NSAI drugs were used in a study of the promoting efficacy of the drugs as adjuvants for the rectal absorption of antibiotics. The promoting effects of adjuvants in dogs were inferior to those in rabbits. From simultaneous measurements of NSAI drugs and antibiotic, it was found that the absorption of antibiotic started at the early stages after the administration of suppositories and the peak blood level was reached while the blood concentration of NSAI drug was still increasing. Apparently the NSAI drugs made the mucosal barrier leaky to water-soluble antibiotics at the early stages of permeation of the NSAI drugs through the rectal membrane, and the barrier rapidly recovered its normal properties even while the permeation of NSAI drug was continuing and a considerable amount of antibiotic still remained in the rectal cavity. A linear correlation between the enhanced absorption of antibiotics and the antiinflammatory activity of NSAI drugs against carrageenan-induced edema was observed
From this literature《Rectal delivery of antiinflammatory drugs. I. The influence of antiinflammatory drugs on rectal absorption of β-lactam antibiotics》,we know some information about this compound(129-18-0)Computed Properties of C19H19N2NaO2, but this is not all information, there are many literatures related to this compound(129-18-0).
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem