Formula: C19H19N2NaO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Influence of nonsteroid antiinflammatory and immunosuppressive drugs on hepatic tryptophan pyrrolase activity in rats. Author is Reinicke, Claus; Guttmacher, Hansjuergen; Ulbricht, Wolfgang.
Orally administered indomethacin [53-86-1] (3 mg/kg), sodium salicylate [54-21-7] (120 mg/kg), acetylsalicylic acid [50-78-2] (300 mg/kg), salicylamide [65-45-2] (160 mg/kg), mefenamic acid [61-68-7] (340 mg/kg), flufenamic acid (I) [530-78-9] (90 mg/kg), amidopyrine [58-15-1] (340 mg/kg), sodium phenylbutazone [129-18-0] (50 mg/kg), and benzydamine-HCl [132-69-4] (200 mg/kg) administered repeatedly did not alter tryptophan pyrrolase [9014-51-1] activity in the liver of intact rats. Orally administerd I increased tyrosine aminotransferase [9014-55-5] activity. Of the nonsteroidal inflammation inhibitors tested, only I and benzydamine blocked the induction of tryptophan pyrrolase by cortisol [50-23-7]. Orally administered cyclophosphamide [50-18-0] (140 mg/kg), triaziquone [68-76-8] (0.45 mg/kg), and azathioprine [446-86-6] increased tryptophan pyrrolase activity, whereas chloroquine diphosphate [50-63-5] (20 mg/kg), 6-mercaptopurine [50-44-2] (75 mg/kg), 6-azauridine [54-25-1] (100 mg/kg), and amethopterin [59-05-2] (2 mg/kg) did not. Induction of tryptophan pyrrolase by cortisol was blocked by azathioprine, 6-mercaptopurine, 6-azauridine, and amethopterin. Enzyme induction is not an essential property of nonsteroidal inflammation inhibitors.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem