Category: 129-18-0

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The carrageenin-induced abscess as a new test for antiinflammatory activity of steroids and nonsteroids》. Authors are Benitz, K. F.; Hall, L. M..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Electric Literature of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The exptl. abscesses were produced by single injections of 0.5 ml. 2% aqueous solution of carrageenin (I) subcutaneously 25-30 mm. rostral of the tail root of female rats. The I abscesses did not alter the behavior of the rats or their body weight The action of drugs against I-induced irritation was determined by giving 1/2 the dose intraperitoneally or orally immediately after the I and the remaining 1/2 approx. 6 hrs. later. The rats were sacrificed 24 hrs. after the I injections and a “”tail pouch”” containing the abscess dissected out for weighing. Antiinflammatory effects were found (decrease in the weight of abscess produced) for Na salicylate, phenylbutazone as the Na salt (II), II plus aminopyrine, hydrocortisone, prednisolone, and triamcinolone. There were differences in the activity of the different drugs and drug combinations but the dose, response curves were essentially linear in each case. The results demonstrated the general utility of the I injection method, and I offered some advantages (discussed) over HCHO or turpentine as an irritation-producing agent. The I did not produce necroses. Possible misleading results due to the so-called counter-irritant effect could be considerably decreased by oral administration of the drugs. The results are interpreted in relation to previous reports on tests for agents which inhibit inflammations. 30 references.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Anti-inflammatory drug actions on allergic responses in guinea-pig skin, the main research direction is allergy inflammation inhibitor; immunosuppressant inflammation inhibitor.Application of 129-18-0.

Five non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin [53-86-1], naproxen [22204-53-1], meclofenamic acid [644-62-2], feprazone Na salt [69227-53-8] and phenylbutazone Na salt [129-18-0] and three glucocorticosteroids (dexamethasone Na phosphate [2392-39-4], hydrocortisone Na phosphate [6000-74-4] and prednisolone Na phosphate [125-02-0]) were tested as local inhibitors of increased vascular permeability in guinea-pig skin. Lesions were induced by histamine or by antigen to evoke type I (passive cutaneous anaphylaxis), type III (reverse passive Arthus) and type IV (delayed hypersensitivity) allergic reactions. NSAIDs and glucocorticosteroids caused either weak, inconsistent inhibition or slight, high-dose inhibition of the response to histamine. None of the drugs tested showed significant inhibition of the type IV response. The NSAIDs caused dose-related inhibition of both type I and type III responses whereas glucocorticosteroids were ineffective. Maximum inhibition with the NSAIDs was never greater than 50-60%. Feprazone, meclofenamic acid and indomethacin were the most potent inhibitors of histamine, PCA, and Arthus responses, resp. The possible significance of the effects of these antiinflammatory agents on vascular permeability is discussed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide(SMILESS: O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+],cas:129-18-0) is researched.Safety of 1-(Bromomethyl)-4-ethylbenzene. The article 《Nonsteroidal antiinflammatory agents and the histamine-releasing agent 48/80》 in relation to this compound, is published in Annales Pharmaceutiques Francaises. Let’s take a look at the latest research on this compound (cas:129-18-0).

Orally administered metiazinic acid [13993-65-2], niflumic acid [4394-00-7], ibuprofen [15687-27-1], indomethacin [53-86-1], and phenylbutazone [50-33-9] had no effect against the ability of compound 48/80 to release histamine [51-45-6] from mast cells, to increase skin capillary permeability, or to cause rat paw edema. When administered locally, the antiinflammatory agents inhibited 48/80 activity at concentrations which could not be attained following oral administration.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Hepatotoxicity of metahexamide》. Authors are Mucci, A.; Marco, G. Di; Lucchi, R..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).SDS of cas: 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

In diabetics treated for a year with metahexamide, Bromsulphalein retention and hippuric acid conjugation test, determination of the quantity of urobilinogen in the urine, and of serum alk. phosphatase, aldolase, and transaminase, as well as of blood levels of Fe and transferrin, and colloidal serum lability tests showed no liver damage. However, in rats treated for a month with the drug, histol. liver damage appeared; in rats treated with tolbutamide the liver remained normal.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Journal of Thermal Analysis and Calorimetry called Synthesis, spectral characterization and thermal studies of zirconyl complexes of biologically active molecules, Author is Jisha, K. R.; Suma, S.; Sudarsanakumar, M. R., the main research direction is zirconyl hippuric acid phenylbutazone chloro hydroxo preparation thermolysis; pyrazolidinedione butylphenyl zirconyl chloro hydroxo preparation thermolysis; second harmonic generation zirconyl hippuric acid chloro hydroxo.Application of 129-18-0.

Zirconyl complexes of hippuric acid (C9H9NO3, hipH) and monophenylbutazone (4-butyl-1-phenyl-3,5-pyrazolidinedione, MPB) were prepared using ZrOCl2·8H2O and ZrO(NO3)3·xH2O and characterized by elemental anal., molar conductance measurement and IR, UV-Vis and NMR spectral methods. Thermal decomposition behavior was studied by thermogravimetry. The second harmonic generation (SHG) conversion efficiency of hippuric acid complexes was also studied.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The composite expectorant Expectin》. Authors are Soltesz, Jeno; Bako, Sandor.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Category: benzofurans. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The use of raw glycyrrhizin (I) improves the quality of the preparation Expectin (II). II is prepared from extracts of primrose root and thyme herbage by the addition of I. No reduction in the hemolytic index was discovered after 1 1/2 years.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 129-18-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Structure of phenylbutazone and mofebutazone in the crystalline state and in solution. Author is Paradies, Henrich H..

The crystal structure of the keto form of phenylbutazone (I) was determined and compared with the mol. conformation of mofebutazone (II). The pronounced differences between these two structures are the conformation of the Bu side chain [which is extended and in trans conformation for II, however, bent at the Cγ-position with H bonding of the γ-H to the carbonyl C(3)-O(1) for I], and the in-plane conformation of the Ph group with respect to the heterocyclic ring system in II compared with two benzene rings at N(1) and N(2) which are almost perpendicular to the pyrazolidine-(3,5)-dione ring. Preliminary x-ray data reveal that the structures of the alkali enolates of both compounds are difficult to solve because the crystal quality is insufficient and highly disordered. However, the large unit cells are consistent with chelated structures of the alkali enolates with solvent. Na and K enolates of I in nonpolar solvents (e.g., benzene and cyclohexane) exist as inverse micelles comprised of 30-40 monomer units. In contrast, the salt appears to be essentially monomeric in 1,2-dimethoxyethane, and, in water for I, the critical micelle concentration (CMC) is >0.30M. II salts, however, reveal a CMC of 1.5 × 10-3M in water, where the basic unit of micellar aggregation seems to be the dimer. The micellar properties of I and II enolates are strongly dependent on the nature of solvents, solvation of the enolate, and size of the cation. However, Na and K enolates of II in nonpolar solvents exist as small inverse micelles comprised of 8-10 monomer units only. In aqueous solution, weight average mol. weights of 13,100 were determined, with a radius of gyration of 12.85 Å.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Experientia called Comparative dominant lethal studies with phenylbutazone, thio-TEPA, and methyl methanesulfonate [MMS] in the mouse, Author is Machemer, L.; Hess, R., the main research direction is phenylbutazone lethal mutation; thio TEPA lethal mutation; methanesulfonate lethal mutation; spermatogenesis thio TEPA; spermatozoa methanesulfonate.Safety of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Thio-TEPA (I) [52-24-4] (5 and 10 mg/kg) and Me methanesulfonate (II) [66-27-3] (50 and 100 mg/kg) given i.p. to male rats before mating induced dominant lethal effects, whereas Na phenylbutazone (III Na salt) [129-18-0] (50 and 100 mg/kg, i.p.) did not. I was highly effective on the postmeiotic stages of spermatogenesis, whereas I was highly effective on epididymal and testicular spermatozoa.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Influence of various drugs on the tissue permeability. I, the main research direction is drug tissue diffusion; tissue drug diffusion.Recommanded Product: 129-18-0.

The effect of drugs, including antiinflammatory drugs, on permeability in s.c. and intracutaneous tissues was tested. The inhibitory activity on permeability was in the decreasing order: N-(ο-methoxybenzoyl)-glycine dimethylamide, 3-aminocamphor-N-acetic acid dimethylamide, Na phenylbutazone, rutin, and histamine-HCl.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Absorption of vitamin B12 by talc》. Authors are Dony, J.; Conter, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Application of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A study of mixtures containing 5-10 γ vitamin B12 (I) and 50 mg. to 1 g. talc indicates I is effectively absorbed by the talc, from which it is slowly and progressively eluted by H2O and is rapidly eluted by gastric media at 37° owing to the pepsin in the media. Tween 20, 1% solution, elutes I from talc in the same manner as does 0.32% pepsin solution and indicates the surface-active function of both compounds in the process.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem