Category: 129-18-0

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Kinetics of drug decomposition. Part 38. Hydrolysis and autoxidation of sodium phenylbutazone and aminophenazone in binary kinetic system, published in 1976, which mentions a compound: 129-18-0, Name is Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, Molecular C19H19N2NaO2, Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The kinetics of hydrolysis and autoxidation of Na phenylbutazone (Na I)(II) [129-18-0] and aminophenazone (III) [58-15-1] in binary sysytems (e.g., Rheumopyrin [8066-94-2] and Irgapyrin [8064-79-7]) was investigated in NH3-AcOH, Carmody and Wefford buffers at different buffer concentration, pH, ionic strengths, and temperature The degradation of II in the presence of III followed 1st order reaction kinetics. III degradation at low concentration (in buffers-Ph 7.13-10.0) was possible only under high excess O. High concentrations of II and III (15%) can be considered as a system stabilizing the degradation, which was regulated by the alk. character of II (pH = 8.6 to 15% II). The lack of effect of different kinds of buffers, ionic strength, and pH on the rate constant of II hydrolysis, qualified the process as a spontaneous reaction initiated by the attack of water mols. The degradation parameters of II in the presence of III, compared with those in its absence, confirm the stabilizing effect of III. In the autoxidation and hydrolysis reaction of II, the changes in the reaction rate depended on the pH. At pH 7.13, the degradation was 3 times faster than at pH 12.07. The activation energy values for the hydrolysis of II without III were lower by 19240 J/mole and for the autoxidation and hydrolysis by 2700 J/mole than those for III present in the reaction medium.

Compounds in my other articles are similar to this one(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C19H19N2NaO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Effect of meseclazone and other non-steroidal antiinflammatory drugs on isolated tracheal chain tone. Author is Diamantis, William; Melton, John L.; Sofia, R. Duane; Ciofalo, Vincent B..

Concentration-dependent relaxation of the isolated guinea pig tracheal chain was produced by the following nonsteroidal antiinflammatory drugs: naproxen [22204-53-1] > ibuprofen [15687-27-1] > diflunisal [22494-42-4] > tolmetin [26171-23-3] ≃ fenoprofen [29679-58-1] ≃ indomethacin [53-86-1] > phenylbutazone Na [129-18-0] > meseclazone (I) [29053-27-8] > 5-chlorosalicylic acid [321-14-2] > aspirin [50-78-2]. All these drugs were less potent than isoproterenol-HCl. This relaxation may be related to inhibition of prostaglandin synthesis, but since the relative potencies of the drugs in the tracheal test did not necessarily correspond to those in inhibiting prostaglandin synthetase in other tissues, other factors may be involved.

When you point to this article, it is believed that you are also very interested in this compound(129-18-0)Synthetic Route of C19H19N2NaO2 and due to space limitations, I can only present the most important information.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of carboxylic acid esters on the experimental hyperkinesis elicited by nicotine》. Authors are Liberman, S. S..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A study was made of the presence of a central nicotinolytic activity in the esters of diphenylacetic acid and its derivatives, which enhanced the resistance to nicotine and lowered the hyperkinesis produced by nicotine. Sixteen compounds were investigated. The dimethylaminoethyl ester of diphenylacetic acid proved the most active. In doses of 25 mg./kg. of body weight this compound prevented the death of the animals from nicotine and lowered the nicotinic hyperkinase to a considerable degree. The esters of benzilic acid, 2-quinuclidylmethyl, 4-pyridylmethyl, and isopropylaminoethyl esters of diphenylacetic acid proved ineffective in preventing nicotinic hyperkinesis. The results of the experiments led the author to conclude that the substitution of a H atom by a methyl group in a hydrocarbon radical which unites phenyl radicals has no substantial effect on the nicotinolytic activity of the compounds; the substitution of a hydroxyl group completely negated the nicotinolytic activity of the compounds

As far as I know, this compound(129-18-0)Product Details of 129-18-0 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Experientia called Specificity of the blood pressure reflex induced by bradykinin, kallidin, and met-kallidin in cats, Author is Wiegershausen, Burkhard; Klausch, B., the main research direction is BLOOD PRESSURE KININS; KININS BLOOD PRESSURE; ACETYLCHOLINES BLOOD PRESSURE; KALLIDINS BLOOD PRESSURE; BRADYKININS BLOOD PRESSURE.Recommanded Product: 129-18-0.

The synthetic kinins, bradykinin acetate (3.1-6.2 × 10-9M), kallidin acetate (2.8-5.6 × 10-9M), and met-kallidin acetate (6.1-12.2 × 10-9M), and acetylcholine chloride (2.2-4.4 × 10-7M), administered via the femoral artery in an isolated hindlimb of a cat, elicited vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane. Atropine blocked the reflex due to acetylcholine, but not the reactions of the kinins. Na phenylbutazone (1.2-2.4 × 10-5M) blocked the reflex reactions of acetylcholine and the kinins, as well as the vasoconstrictor effect of histamine-2HCl and the kinins in the isolated hindlimb.

In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Recommanded Product: 129-18-0, illustrating the importance and wide applicability of this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Study of two new non-steroid antiinflammatory drugs having a pyrazole structure (LM 22070 and LM 22102). Author is Mizoule, J.; Le Fur, G.; Uzan, A..

Two derivatives from a new heteroarylacetic series, LM 22102 (I) [50270-32-1] and LM 22070 (II) [50270-33-2], were selected on the basis of their antiinflammatory, analgesic, and antipyretic properties. In the mouse, I and II, resp., were 15 and 30 times less active than indomethacin ethanolamine salt [71227-27-5] in Koster’s test, but they were 9 and 13 times less toxic than the reference drugs. In contrast, they were very active in the rat and the guinea pig. I was as active as indomethacin in the various tests . In vitro, its inhibition of prostaglandin synthetase [9055-65-6] in guinea pig lung was more powerful than that of indomethacin. Like all potent nonsteroid antiinflammatory drugs I had ulcerogenic activity, similar to that of indomethacin, which accounted for its acute oral toxicity in the rat. The activities of II were either the same as (antipyretic action) or inferior to (analgesic and antiinflammatory activity and inhibition of prostaglandin synthetase) that of indomethacin, but were always superior to those of phenylbutazone sodium salt [129-18-0]. Its ulcerogenic activity and oral acute toxicity in the rat are 2.5- and 3-fold weaker than those of indomethacin, resp.

This literature about this compound(129-18-0)Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idehas given us a lot of inspiration, and I hope that the research on this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Acute renal insufficiency following the therapeutic application of phenylbutazone》. Authors are Streicher, E..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Electric Literature of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Normal renal function was restored by means of extracorporeal dialysis in 4 cases of acute renal insufficiency apparently resulting from the administration of the phenylbutazone-containing drugs, Butazolidine, Delta-butazolidin, Irgapyrine, and Tomanol. A review was given of this and other side-reactions resulting from the administration of this class of drug. 71 references.

This literature about this compound(129-18-0)Electric Literature of C19H19N2NaO2has given us a lot of inspiration, and I hope that the research on this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Five years’ experience with the evaluation of diuretic agents. Author is Swartz, Charles; Seller, Robert; Fuchs, Morton; Brest, Albert N.; Moyer, John H..

Evaluation of 12 diuretics and 2 combinations of diuretics in normal hospitalized patients permitted only separation of drugs into a few overlapping categories of potency. The combination of a mercurial and a thiazide caused significantly greater Na excretion than any other drug used alone. No single diuretic was significantly more potent than all the others.

This literature about this compound(129-18-0)Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idehas given us a lot of inspiration, and I hope that the research on this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea pig to drugs and to coaxial stimulation》. Authors are Seferna, I.; Lukomskaya, N.; Kadlec, O.; Janku, I..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Small concentrations of 6-azauridine augmented the contractions of the isolated guinea pig ileum to acetylcholine, nicotine, histamine, barium chloride, and coaxial stimulation. High concentrations partially inhibited all the responses. After prolonged contact with high concentrations of 6-azauridine, the antispasmogenic effect persisted long after washing out the compound The acetylcholine output did not change under these conditions. Comparison of the actions of 6-azauridine with those of papaverine is made and the possible mechanisms of action are discussed.

As far as I know, this compound(129-18-0)Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C19H19N2NaO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antigranuloma and thymolytic activity of certain drugs. Author is Silvestrini, B.; Lisciani, R.; Scorza Barcellona, P..

The possibility that the antigranuloma action of corticosteroids is mediated by the thymus gland was studied in intact, thymectomized, and adrenalectomized rats having granulomas induced by cotton-pellet implantation. In intact rats, s.c. injected cortisone acetate (I) (30 and 50 mg./kg.) inhibited body weight increases and reduced the weights of the granuloma, thymus gland, and spleen. The effects of I were dose dependent; at 5 mg./kg., s.c. body growth and granuloma were inhibited, whereas an oral dose of 50 mg./kg. inhibited the granuloma and reduced the weights of the thymus gland and spleen. Na phenylbutazone and benzydamine-HCl selectively inhibited granuloma, but even doses of 50 mg./kg., s.c., and 80 mg./kg., orally, of Na phenylbutazone and up to 500 mg./kg., orally, of benzydamine-HCl did not significantly reduce thymus and spleen weights Testosterone (10 and 50 mg./kg., s.c.) reduced the weight of the thymus gland at the lower dosage and at the higher dose reduced that of the granuloma. Morphine sulfate (5 and 20 mg./kg.) inhibited the granuloma, thymus, and thyroid gland weights and increased that of the adrenal gland. In the adrenalectomized rats, I and testosterone exhibited biol. activity, whereas morphine sulfate was inactive. In thymectomized animals, the granuloma, body, and internal organ weights were similar to those of controls and I was still active. 18 references.

In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)COA of Formula: C19H19N2NaO2, illustrating the importance and wide applicability of this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Farmaco, Edizione Scientifica called Pharmacology of p-hydroxypropiophenone sulfate, Author is Setnikar, I.; Murmann, W., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The Na salt has low toxicity in acute and chronic application. It is well tolerated when injected locally in not too concentrated solutions It does not inhibit the pituitary secretion of adrenocorticotropin in the normal animal or in stress of variable severity. It neither inhibits the secretion of somatotropic hormone nor has any influence on the normal growth. It does, however, inhibit the secretion of gonadotropin by the pituitary if this secretion is abnormally high. It also inhibits thyrotropic hyperfunction of the hypophysis if a hyperfunction exists. The antigonadotropic and antithyrotropic action does not occur peripherally, but it has a central point of attack either on the hypophysis or on the centers that govern this gland. The effect on the pituitary is not caused by an estrogenic effect.

In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, illustrating the importance and wide applicability of this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem