Category: 129-18-0

Category: benzofurans. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about [Effect of] prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro. Author is Burka, J. F.; Eyre, P..

Sodium meclofenamate [6385-02-0] and phloretin phosphates dimer blocked PGE2 (I) [363-24-6]-induced contractions of bovine pulmonary vein whereas relaxations were not blocked. Diethylcarbamazine citrate [1642-54-2] inhibited the relaxant effect of I but it also antagonized the contractile effects of histamine, 5-hydroxytryptamine, and PGF2α [551-11-1] so its action was rather nonspecific. Phenylbutazone Na [129-18-0] antagonized the contractile and relaxant actions of I and the contractile actions of PGF2α. By classifying receptors by antagonism, the bovine pulmonary vein appears to contain I phenylbutazone-type, I Na meclofenamate-type, I phloretin phosphate -type, and PGF2α phenylbutazone-type receptors.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Nature (London), New Biology called Enzyme release from guinea pig polymorphonuclear leukocyte lysosomes inhibited in vitro by antiinflammatory drugs, Author is Ignarro, Louis J.; Colombo, Carmelo, the main research direction is antiinflammatory drug lysosome enzyme release; aryl sulfatase release antiinflammatory drug; glucuronidase release antiinflammatory drug; galactosidase release antiinflammatory drug.Related Products of 129-18-0.

Chloroquine phosphate [50-63-5], hydrocortisone phosphate [3863-59-0], phenylbutazone [50-33-9] oxyphenbutazone [129-20-4], acetylsalicylic acid [50-78-2], indomethacin [53-86-1], and flufenamic acid [530-78-9] inhibited the release of aryl sulfatase [9016-17-5] from a guinea pig polymorphonuclear leukocyte granule suspension incubated in hypotonic sucrose-Tris buffer at neutral pH and 37.deg.. The Na salts of phenylbutazone, acetylsalicylic acid, and indomethacin were more active than their resp. free acids. Most of the acidic drugs gave slightly lower vlaues of inhibition of enzyme release at 10-5 M than at 10-l M. The antiinflammatory drugs also inhibited release of β-glucuronidase [9001-45-0] and β-galactosidase [9031-11-2] from the leukocyte granules. In this case, the biphasic action of acidic drugs was observed only at concentrations .geq.10-4M.

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Benzofuran – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Antacids. II. Gel of aluminum hydroxide》. Authors are Okasaki, Kanzo; Tanabe, Shizuko.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Synthetic Route of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The antacidic effectiveness of Al(OH)3 is studied by the modified Fuchs’ method. The efficacy of the spray-dried gel is better than the one dried at low temperature The efficacy decreases in the order liquid gel, dried gel, and granules. Even if dried gel is suspended in water, its efficacy is not improved. The efficacy is related not only to the size of particles, but also to aging. Mech. mixture of dried gel and other antacids, such as Mg salts, did not improve the antacid efficacy, but such mixtures treated with water showed good result.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analysis of mixed preparations. II. Determination of antihistaminics in the mixed preparations》. Authors are Itai, Takanobu; Kamiya, Shozo.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).HPLC of Formula: 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

cf. C.A. 51, 12433f. Antihistaminics, contained in the preparations for colds with various other ingredients, can be determined colorimetrically by precipitation as reineckates. By regulating the pH of their solutions or changing the quantity of added MeOH, the differential determination from other basic ingredients is accomplished. For the determination of antihistaminics in the mixture of aspirin, phenacetin, and caffeine, samples are dissolved in water and the antihistamine is precipitated with 2% NH4 reineckate in MeOH solution In the presence of aminopyrine or antipyrine, Clark-Lubs’ buffer solution is added in order to hold the pH of the solution at 6.5-7.0, then NH4 reineckate is added. The reineckate of ephedrine or methylephedrine is more soluble in MeOH than that of antihistaminics. From preparations containing thiamine, free antihistamine base is extracted with Et2O after adding K2HPO4. The aqueous solution hereby obtained is used for the determination of thiamine as its reineckate. Antihistaminics in the mixture of aspirin, phenacetin, and caffeine are titrated as free bases by passing through a column of Amberlite IR-4B (OH form). As aspirin is adsorbed on the resin, it is eluted with 50% alc. solution of N HCl, and titrated by bromometry.

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Benzofuran – Wikipedia,
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Recommanded Product: 129-18-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Modification of the cardiac activity of digoxin by phenylbutazone and sodium salicylate. Author is Ammar, Elsayed M.; Elakkad, Ibrahim N.; Elbitar, Hussein H..

Daily oral treatment with the phenylbutazone-Na [129-18-0] or Na salicylate [54-21-7] for 2 weeks decreased the cardiac activity of digoxin (I) [20830-75-5], as indicated by an increase in its lethal dose in guinea pigs. The uptake of I by ventricular strips from rabbits, pretreated with phenylbutazone or sodium salicylate, was decreased, and this decrease may explain its decreased cardiac activity. Competition between the 2 antirheumatic drugs and I is discussed at both the plasma protein and the cardiac tissue levels. Thus, drug interactions and the subsequent decreased clinical effectiveness of I occur when I is prescribed in combination with phenylbutazone or sodium salicylate.

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Benzofuran – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Microsomal mixed function oxidases in an estuarine fish, Fundulus heteroclitus, and their induction as a result of environmental contamination.SDS of cas: 129-18-0.

Aldrin [309-00-2] epoxidation by the hepatic microsomal mixed function oxidase (I) [9038-14-6] of F. heteroclitus required NADPH and was prevented by CO. Cytochrome P450 [9035-51-2] was observed in hepatic microsomes of F. heteroclitus. High levels of I were induced by Na phenylbutazone [129-18-0] (10 and 100 ppb) and by contamination of the aquatic environment by foreign hydrocarbons.

Although many compounds look similar to this compound(129-18-0)SDS of cas: 129-18-0, numerous studies have shown that this compound(SMILES:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Benzofuran – Wikipedia,
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Product Details of 129-18-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Bioavailability and anti-inflammatory effects of phenylbutazone sodium and phenylbutazone calcium in rats. Author is Hanada, S.; Mengardo, S.; Oga, S..

Phenylbutazone Na and phenylbutazone Ca had similar half-lives (5 h), area under concentration-time the curve (520 μg h/mL), elimination coefficients (14/min), and total body clearance (101 mL/kg/h) after oral administration to rats. The 2 compounds had similar anti-inflammatory activities, but, in fasted animals, the Na salt caused more gastroduodenal lesions than the Ca salt.

Although many compounds look similar to this compound(129-18-0)Product Details of 129-18-0, numerous studies have shown that this compound(SMILES:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about β-Lipoproteins: possible plasma transport proteins for basic drugs. Author is Vallner, J. J.; Chen, L..

The interactions between β-lipoprotein and drugs, as measured by difference spectrophotometry, apparently occurred at more than a single class of sites on the β-lipoprotein. β-Lipoprotein may act in conjunction with albumin in the plasma transport of basic or cationic drugs.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Further evidence for the involvement of kinin in anaphylactic shock in the rat.Related Products of 129-18-0.

Na phenylbutazone, soybean trypsin inhibitor, or the concomitant administration of ascorbic acid and mepyramine protected rats against anaphylactic shock at 10 days after sensitization but gave no protection against anaphylaxis at 20 days. During anaphylactic shock in rats at 10 days after sensitization, the plasma bradykinin and bradykininogen levels, as well as those in the intestinal lumen and peritoneal cavity, were markedly raised. The results support the hypothesis that there are 2 phases in anaphylaxis in the rat-an early phase in which bradykinin is a mediator and against which phenylbutazone or soybean trypsin inhibitor or the mixture of ascorbic acid and mepyramine, give protection, and a late phase which does not involve bradykinin.

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Aarsen, P. N.; Zeegers, A. published the article 《Effects of histamine, 5-hydroxytryptamine, and bradykinin on the vascular system of isolated lungs of the guinea pig and the influence of phenylbutazone on these effects》. Keywords: histamine vasoconstriction; serotonin vasoconstriction; bradykinin vasoconstriction; phenylbutazone vasoconstriction.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Application of 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

In isolated lungs of the guinea pig perfused through pulmonary artery repeated doses of histamine acid phosphate [51-74-1] progressively increased pulmonary arterial pressure and decreased fluctuations in tracheal pressure. Phenylbutazone Na [129-18-0] almost completely abolished the effect of histamine on the arterial pressure and suppressed the progression of the effect on tracheal pressure. The effects of 5-hydroxytryptamine creatinine sulfate [971-74-4] and bradykinin [58-82-2] did not show such progression. Further experiments indicated that repeated administration of histamine causes an accumulation of fluid in the lungs probably mainly in the interstitial spaces, which results in an inhibition of the tracheal pressure fluctuations. Phenylbutazone prevents this effect by suppressing the vasoconstrictor action of histamine without affecting the increased vascular permeability.

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Reference:
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