Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Nature (London), New Biology called Enzyme release from guinea pig polymorphonuclear leukocyte lysosomes inhibited in vitro by antiinflammatory drugs, Author is Ignarro, Louis J.; Colombo, Carmelo, the main research direction is antiinflammatory drug lysosome enzyme release; aryl sulfatase release antiinflammatory drug; glucuronidase release antiinflammatory drug; galactosidase release antiinflammatory drug.Related Products of 129-18-0.
Chloroquine phosphate [50-63-5], hydrocortisone phosphate [3863-59-0], phenylbutazone [50-33-9] oxyphenbutazone [129-20-4], acetylsalicylic acid [50-78-2], indomethacin [53-86-1], and flufenamic acid [530-78-9] inhibited the release of aryl sulfatase [9016-17-5] from a guinea pig polymorphonuclear leukocyte granule suspension incubated in hypotonic sucrose-Tris buffer at neutral pH and 37.deg.. The Na salts of phenylbutazone, acetylsalicylic acid, and indomethacin were more active than their resp. free acids. Most of the acidic drugs gave slightly lower vlaues of inhibition of enzyme release at 10-5 M than at 10-l M. The antiinflammatory drugs also inhibited release of β-glucuronidase [9001-45-0] and β-galactosidase [9031-11-2] from the leukocyte granules. In this case, the biphasic action of acidic drugs was observed only at concentrations .geq.10-4M.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem