Aarsen, P. N.; Zeegers, A. published the article 《Effects of histamine, 5-hydroxytryptamine, and bradykinin on the vascular system of isolated lungs of the guinea pig and the influence of phenylbutazone on these effects》. Keywords: histamine vasoconstriction; serotonin vasoconstriction; bradykinin vasoconstriction; phenylbutazone vasoconstriction.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Application of 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.
In isolated lungs of the guinea pig perfused through pulmonary artery repeated doses of histamine acid phosphate [51-74-1] progressively increased pulmonary arterial pressure and decreased fluctuations in tracheal pressure. Phenylbutazone Na [129-18-0] almost completely abolished the effect of histamine on the arterial pressure and suppressed the progression of the effect on tracheal pressure. The effects of 5-hydroxytryptamine creatinine sulfate [971-74-4] and bradykinin [58-82-2] did not show such progression. Further experiments indicated that repeated administration of histamine causes an accumulation of fluid in the lungs probably mainly in the interstitial spaces, which results in an inhibition of the tracheal pressure fluctuations. Phenylbutazone prevents this effect by suppressing the vasoconstrictor action of histamine without affecting the increased vascular permeability.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem