The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of carboxylic acid esters on the experimental hyperkinesis elicited by nicotine》. Authors are Liberman, S. S..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.
A study was made of the presence of a central nicotinolytic activity in the esters of diphenylacetic acid and its derivatives, which enhanced the resistance to nicotine and lowered the hyperkinesis produced by nicotine. Sixteen compounds were investigated. The dimethylaminoethyl ester of diphenylacetic acid proved the most active. In doses of 25 mg./kg. of body weight this compound prevented the death of the animals from nicotine and lowered the nicotinic hyperkinase to a considerable degree. The esters of benzilic acid, 2-quinuclidylmethyl, 4-pyridylmethyl, and isopropylaminoethyl esters of diphenylacetic acid proved ineffective in preventing nicotinic hyperkinesis. The results of the experiments led the author to conclude that the substitution of a H atom by a methyl group in a hydrocarbon radical which unites phenyl radicals has no substantial effect on the nicotinolytic activity of the compounds; the substitution of a hydroxyl group completely negated the nicotinolytic activity of the compounds
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem