The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Hepatotoxicity of metahexamide》. Authors are Mucci, A.; Marco, G. Di; Lucchi, R..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).SDS of cas: 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.
In diabetics treated for a year with metahexamide, Bromsulphalein retention and hippuric acid conjugation test, determination of the quantity of urobilinogen in the urine, and of serum alk. phosphatase, aldolase, and transaminase, as well as of blood levels of Fe and transferrin, and colloidal serum lability tests showed no liver damage. However, in rats treated for a month with the drug, histol. liver damage appeared; in rats treated with tolbutamide the liver remained normal.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem