The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Anti-inflammatory drug actions on allergic responses in guinea-pig skin, the main research direction is allergy inflammation inhibitor; immunosuppressant inflammation inhibitor.Application of 129-18-0.
Five non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin [53-86-1], naproxen [22204-53-1], meclofenamic acid [644-62-2], feprazone Na salt [69227-53-8] and phenylbutazone Na salt [129-18-0] and three glucocorticosteroids (dexamethasone Na phosphate [2392-39-4], hydrocortisone Na phosphate [6000-74-4] and prednisolone Na phosphate [125-02-0]) were tested as local inhibitors of increased vascular permeability in guinea-pig skin. Lesions were induced by histamine or by antigen to evoke type I (passive cutaneous anaphylaxis), type III (reverse passive Arthus) and type IV (delayed hypersensitivity) allergic reactions. NSAIDs and glucocorticosteroids caused either weak, inconsistent inhibition or slight, high-dose inhibition of the response to histamine. None of the drugs tested showed significant inhibition of the type IV response. The NSAIDs caused dose-related inhibition of both type I and type III responses whereas glucocorticosteroids were ineffective. Maximum inhibition with the NSAIDs was never greater than 50-60%. Feprazone, meclofenamic acid and indomethacin were the most potent inhibitors of histamine, PCA, and Arthus responses, resp. The possible significance of the effects of these antiinflammatory agents on vascular permeability is discussed.
In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Application of 129-18-0, illustrating the importance and wide applicability of this compound(129-18-0).
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem