Day: February 23, 2023

Rapid pyrolysis of coals in a down-flow reactor. II. Analysis of Taiheiyo coal tars by GC/MS was written by Morita, Mikio;Hirosawa, Kunio. And the article was included in Nenryo Kyokaishi in 1991.Application of 205-39-0 This article mentions the following:

Taiheiiyo coal was flash pyrolyzed at 600° and 800° in a down-flow type reactor, and the fractions of ≤360° of the coal tar were analyzed by gas chromatog./mass spectrometry (GC/MS). The coal tar fractions from 600° pyrolysis contained 453 compounds, e.g. aliphatic hydrocarbons, alkylbenzenes, Tetralin derivatives, alkylnaphthalenes, etc. The coal tar fractions from 800° pyrolysis contained 249 compounds, e.g. phenols, naphthalenes, anthracene, etc. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Application of 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microfluidic reactors based on rechargeable catalytic porous supports: Heterogeneous enzymatic catalysis via reversible host-guest interactions was written by Sanz de Leon, Alberto;Vargas-Alfredo, Nelson;Gallardo, Alberto;Fernandez-Mayoralas, Alfonso;Bastida, Agatha;Munoz-Bonilla, Alexandra;Rodriguez-Hernandez, Juan. And the article was included in ACS Applied Materials & Interfaces in 2017.HPLC of Formula: 3326-34-9 This article mentions the following:

We report on the fabrication of a microfluidic device in which the reservoir contains a porous surface with enzymic catalytic activity provided by the reversible immobilization of horseradish peroxidase onto micrometer size pores. The porous functional reservoir was obtained by the Breath Figures approach by casting in a moist environment a solution containing a mixture of high mol. weight polystyrene (HPS) and a poly(styrene-co-cyclodextrin based styrene) (P(S-co-SCD)) statistical copolymer. The pores enriched in CD were employed to immobilize horseradish peroxidase (previously modified with adamantane) by host-guest interactions (HRP-Ada). These surfaces exhibit catalytic activity that remains stable during several reaction cycles. Moreover, the porous platforms could be recovered by using free water-soluble β-CD with detergents. An excess of β-CD/TritonX100 in solution disrupts the interactions between HRP-Ada and the CD-modified substrate thus allowing us to recover the employed enzyme and reuse the platform. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9HPLC of Formula: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Benzofuran-oxadiazole hybrids: design, synthesis and antimicrobial activity studies was written by Sanjeeva, P.;Subba, Rao B.;Kamala, Prasad V.;Venkata, Ramana P.. And the article was included in Research Journal of Chemistry and Environment in 2021.SDS of cas: 10242-11-2 This article mentions the following:

The six benzofuran-oxadiazole derivatives I [R = ClH₂C, BrH₂C, C₆H₅, etc.] were designed, synthesized, characterized and evaluated for antimicrobial activity. The key synthetic intermediate 5-bromo-N’-hydroxybenzofuran-2-carboxamidine was prepared from 5-bromobenzofuran-2-carboxylic acid in two consecutive steps involving reaction with NaN₃, in presence of TEA, Xtalfluor-E, PPh₃ in dry DCM at 0°C followed by the treatment of resulting carbonitrile with hydroxylamine hydrochloride in presence of sodium methoxide under reflux in aqueous ethanol. Reaction of carboxamidine with different aryl esters in presence of K²CO₃ under reflux conditions in toluene afforded 3-(5-bromobenzofuran-2-yl)-5-substituted phenyl-1,2,4-oxadiazoles I [R = C₆H₅, 2-HOC₆H₄, 4-ClC₆H₄, 4-pyridinyl] while the refluxion of a solution of carboxamidine in dichloromethane with chloro/bromo acetyl chloride in presence of TEA and a catalytic amount of HBTU furnished I [R = ClH₂C, BrH₂C]. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2SDS of cas: 10242-11-2).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.SDS of cas: 10242-11-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Branched Amine Synthesis via Aziridine or Azetidine Opening with Organotrifluoroborates by Cooperative Bronsted/Lewis Acid Catalysis: An Acid-Dependent Divergent Mechanism was written by Nguyen, Truong N.;May, Jeremy A.. And the article was included in Organic Letters in 2018.Recommanded Product: Potassium benzofuran-2-yltrifluoroborate This article mentions the following:

A practical catalytic method to synthesize β,β- and γ,γ-substituted amines by opening aziridines and azetidines, resp., using alkenyl, alkynyl, or aryl/heteroaryl trifluoroborate salts is described. This reaction features simple open-flask reaction conditions, the use of transition-metal-free catalysis, complete regioselectivity, and high diastereoselectivity. Preliminary mechanistic studies suggest that carbocation formation is disfavored. Stereoretentive addition is favored with Bronsted acid present, while stereoinversion is favored in its absence, indicating divergent mechanisms. In the experiment, the researchers used many compounds, for example, Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7Recommanded Product: Potassium benzofuran-2-yltrifluoroborate).

Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: Potassium benzofuran-2-yltrifluoroborate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC determination of trifolirhizin in Sophora flavescens Ait. was written by Zhao, Huijuan;Wang, Daqi;Sun, Wenji. And the article was included in Yaowu Fenxi Zazhi in 2005.Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

An HPLC method for determination of trifolirhizin in Sophora flavescens Ait was established. SUPELCO C₁₈ column (25 cm×4.6 mm, 5 μm) was used, and the mobile phase consisted of MeOH-H₂O (1:1). The flow rate was 1.0 mL·min^-1, and the determination wavelength was 310 nm. The linear range was 0.41-4.10 μg (r=0.9998). The average recoveries were 98.72%, 99.20% and 99.47%; and RSD was 1.1%, 1.5% and 2.2% (n=3), resp. This method is simple, rapid and reliable for determination of trifolirhizin in Sophora flavescens Ait. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Bipartite network models to design combination therapies in acute myeloid leukaemia was written by Jafari, Mohieddin;Mirzaie, Mehdi;Bao, Jie;Barneh, Farnaz;Zheng, Shuyu;Eriksson, Johanna;Heckman, Caroline A.;Tang, Jing. And the article was included in Nature Communications in 2022.Reference of 850879-09-3 This article mentions the following:

Combination therapy is preferred over single-targeted monotherapies for cancer treatment due to its efficiency and safety. However, identifying effective drug combinations costs time and resources. We propose a method for identifying potential drug combinations by bipartite network modeling of patient-related drug response data, specifically the Beat AML dataset. The median of cell viability is used as a drug potency measurement to reconstruct a weighted bipartite network, model drug-biol. sample interactions, and find the clusters of nodes inside two projected networks. Then, the clustering results are leveraged to discover effective multi-targeted drug combinations, which are also supported by more evidence using GDSC and ALMANAC databases. The potency and synergy levels of selective drug combinations are corroborated against monotherapy in three cell lines for acute myeloid leukemia in vitro. In this study, we introduce a nominal data mining approach to improving acute myeloid leukemia treatment through combinatorial therapy. In the experiment, the researchers used many compounds, for example, N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3Reference of 850879-09-3).

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 850879-09-3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nickel-Promoted Recognition of Long DNA Sites by Designed Peptide Derivatives was written by Rodriguez, Jessica;Mosquera, Jesus;Vazquez, M. Eugenio;Mascarenas, Jose L.. And the article was included in Chemistry – A European Journal in 2016.Safety of H-Arg(Pbf)-OH This article mentions the following:

We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of Ni^II salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal-chelating His and bipyridine ligands. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Safety of H-Arg(Pbf)-OH).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of H-Arg(Pbf)-OH

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation and characterization of novel photoinitiator organically-modified MMT and its EA/MMT UV-cured nanocomposites was written by Chen, Baiqiu;Zang, Yangling;Liu, Guangpeng;Xu, Weijian. And the article was included in Jingxi Huagong Zhongjianti in 2008.Category: benzofurans This article mentions the following:

The EA/MMT UV-cured nanocomposites were prepared using modified clays and epoxy resin via intra-gallery UV-curing polymerization, and the organic modified clays were used as the only photoinitiator. The organic modified clays were modified by novel long-chain type quaternary ammonium salt photoinitiator benzoylbenzyl-N,N-dimethyl-N-octadecylammonium bromide, which was synthesized by the reaction of 4-bromomethyl benzophenone with octadecyl di-Me amine. The morphol. of the UV-cured EA/MMT nanocomposites prepared from this organically-modified MMT has been studied using XRD and TEM, and the results have shown an intercalated structure with partially exfoliation for all the samples. Exptl. results from TGA and mech. property testing have also indicated that the thermal and mech. properties of UV-cured nanocomposites were significantly enhanced. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Category: benzofurans).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical Characterization of Fine Particle Emissions from the Fireplace Combustion of Woods Grown in the Southern United States was written by Fine, Philip M.;Cass, Glen R.;Simoneit, Bernd R. T.. And the article was included in Environmental Science and Technology in 2002.Application of 205-39-0 This article mentions the following:

The fireplace combustion of wood is a significant and largely unregulated source of fine particle pollution in the USA. Source apportionment techniques that use particulate organic compounds as tracers have been successful in determining the contribution of wood smoke to ambient fine particle levels in specific areas in California. To apply these techniques to the rest of the USA, the differences in emissions profiles between different wood smoke sources and fuel types should be resolved. To this end, a series of fireplace source tests was conducted on six fuel wood species found in the Southern USA to determine fine particulate emission factors for total mass, ionic and elemental species, elemental and organic carbon, and over 250 individual organic compounds The wood species tested, chosen for their high abundance and availability in the Southern US region, were yellow poplar, white ash, sweetgum, mockernut hickory, loblolly pine, and slash pine. The differences in the emissions of compounds such as substituted phenols and resin acids help to distinguish between the smoke from hardwood and softwood combustion. Levoglucosan, a cellulose pyrolysis product which may serve as a tracer for wood smoke in general, was quantified in the emissions from all the wood species burned. The furofuran lignan, yangambin, which was emitted in significant quantities from yellow poplar combustion and not detected in any of the other North American wood smokes, is a potential species-specific mol. tracer which may be useful in qual. identifying particulate emissions from a specific geog. area where yellow poplar is being burned. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Application of 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical Labeling and Affinity Capture of Inosine-Containing RNAs Using Acrylamidofluorescein was written by Knutson, Steve D.;Ayele, Tewoderos M.;Heemstra, Jennifer M.. And the article was included in Bioconjugate Chemistry in 2018.COA of Formula: C20H13NO5 This article mentions the following:

Adenosine-to-inosine (A-to-I) RNA editing is a widespread and conserved posttranscriptional modification, producing significant changes in cellular function and behavior. Accurately identifying, detecting, and quantifying these sites in the transcriptome is necessary to improve the understanding of editing dynamics, its broader biol. roles, and connections with diseases. Chem. labeling of edited bases coupled with affinity enrichment has enabled improved characterization of several forms of RNA editing. However, there are no approaches currently available for pull-down of inosines. To address this need, the authors explore acrylamide as a labeling motif and report here an acrylamidofluorescein reagent that reacts with inosine and enables enrichment of inosine-containing RNA transcripts. This method provides improved sensitivity in the detection and identification of inosines toward a more comprehensive transcriptome-wide anal. of A-to-I editing. Acrylamide derivatization is also highly generalizable, providing potential for the labeling of inosine with a wide variety of probes and affinity handles. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9COA of Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem