Day: November 21, 2022

Mokhtari Brikci-Nigassa, Nahida published the artcileFunctionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest, HPLC of Formula: 69626-75-1, the publication is Bioorganic Chemistry (2020), 103347, database is CAplus and MEDLINE.

Original 1-amino substituted thioxanthone derivatives were easily prepared from the bare heterocycle by a deprotometalation-iodolysis-copper-catalyzed C-N bond formation sequence. This last reaction delivered mono- or/and diarylated products I (R = 4-FC₆H₄, 1-naphthyl, 3-aminopyridin-2-yl, etc.) and II (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₄) depending on the anilines RNH₂ involved. 1-Amino-9-thioxanthone was also prepared and reacted with 2-iodoheterocycles R¹I (R¹ = 2-thienyl, 1-benzothiophen-2-yl, 1-benzofuran-2-yl). Interestingly, while 1-(arylamino)-9-thioxanthones like 1-(2-thienylamino)-9-thioxanthone and 1-(2-benzothienylamino)-9-thioxanthone could be isolated, their subsequent cyclization was found to deliver original hexacyclic derivatives like [1]benzothiopyrano[4,3,2-de]benzothieno[2,3-b]quinoline and [1]benzothiopyrano[4,3,2-de]benzofuro[2,3-b]quinoline of helicoidal nature. Evaluation of their photophys. properties revealed high fluorescence in polar media, indicating potential applications for biol. imaging. These compounds being able to inhibit PIM1 kinase, their putative binding mode was examined through mol. modeling experiments Altogether, these results tend to suggest the discovery of a new family of fluorescent PIM inhibitors and pave the way for their future rational optimization.

Bioorganic Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Amao, Yutaka published the artcileAn optical sensor with the combination of colorimetric change of α-naphtholphthalein and internal reference luminescent dye for CO₂ in water, Computed Properties of 596-01-0, the publication is Sensors and Actuators, B: Chemical (2005), 107(2), 861-865, database is CAplus.

A new optical CO₂ sensor based on luminescence intensity changes of tetraphenylporphyrin (TPP) due to the absorption change of pH indicator dye (α-naphtholphthalein) with CO₂ is developed and its CO₂ sensing properties in pure H₂O were studied. The observed luminescence intensity from TPP at 650 nm increased with increasing the CO₂ concentration in pure H₂O. The ratio I₁₀₀/I₀, where I₀ and I₁₀₀ represent the detected luminescence intensities from a layer exposed to 100% Ar and 100% CO₂, resp., that the authors takes the sensitivity of the sensor is 430. The response times of the sensing film are 42.6 s for switching from Ar to CO₂, and 88.8 s for switching from CO₂ to Ar in pure H₂O. The signal changes are fully reversible and no hysteresis is observed during the measurements.

Sensors and Actuators, B: Chemical published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Computed Properties of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Amao, Yutaka published the artcileOptical CO₂ sensor with the combination of colorimetric change of α-naphtholphthalein and internal reference fluorescent porphyrin dye, Computed Properties of 596-01-0, the publication is Sensors and Actuators, B: Chemical (2004), 100(3), 347-351, database is CAplus.

A new optical CO₂ sensor based on the overlay of the CO₂ induced absorbance change of pH indicator dye α-naphtholphthalein with the fluorescence of tetraphenylporphyrin (TPP) was developed. The observed luminescence intensity from TPP at 655 nm increased with increasing the CO₂ concentration The ratio I₁₀₀/I₀ values of the sensing films consisting of α-naphtholphthalein in Et cellulose layer and TPP in polystyrene layer, where I₀ and I₁₀₀ represent the detected luminescence intensities from a layer exposed to 100% nitrogen and 100% CO₂, resp., that the sensitivity of the sensor, are >53.9. The response and recovery times of the sensing films consisting of α-naphtholphthalein in Et cellulose layer and TPP in polystyrene layer were <5 s for switching from nitrogen to CO₂, and for switching from CO₂ to nitrogen. The signal changes were fully reversible and no hysteresis was observed during the measurements. The highly sensitive optical CO₂ sensor based on fluorescence intensity changes of TPP due to the absorption change of α-naphtholphthalein with CO₂ was achieved.

Sensors and Actuators, B: Chemical published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Computed Properties of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Sichaem, Jirapast published the artcileChemical Constituents of the Leaves of Artocarpus integer, HPLC of Formula: 56317-21-6, the publication is Chemistry of Natural Compounds (2022), 58(3), 538-540, database is CAplus.

During our recent chem. investigation, 11 compounds, epiafzelechin (1) , (+)-epicatechin (2), 3β-hydroxy-7α-methoxy-24β-ethylcholest-5-ene (3) , isobavachalcone (4), kuwanon J (5), moracin M (6), morachalcone A (7) ,apigenin (8) , scopoletin (9), ferulic acid (10), and luteolin (11) were isolated from the leaves of A. integer. Their structures were identified by interpretation of their spectroscopic data and comparison with those reported in the literature. Among these compounds, compounds 2, 6, and 11 exhibited potent antioxidant activity in DPPH radical scavenging with IC50 values of 20.59 ± 0.56, 54.17 ± 1.84, and 26.43 ± 0.17 μg/mL, resp.

Chemistry of Natural Compounds published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C17H18N2O6, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Rao, Maddali L. N. published the artcileFunctional group manoeuvering for tuning stability and reactivity: synthesis of cicerfuran, moracins (D, E, M) and chromene-fused benzofuran-based natural products, Computed Properties of 56317-21-6, the publication is Organic & Biomolecular Chemistry (2017), 15(44), 9415-9423, database is CAplus and MEDLINE.

The protecting group maneuvering as a strategy was applied for tuning the stability and reactivity of 4-(2,2-dibromovinyl)benzene-1,3-diol and 6-(2,2-dibromovinyl)-2,2-dimethylchroman-7-ol in the domino synthesis of benzofuran-based natural products. The functional group demands and their impact on the reactivity driven by electronic effects were successfully managed by varying the protecting groups with substituted gem-dibromovinylphenols in domino couplings and triarylbismuth reagents under palladium-catalyzed conditions. This approach paved the way for the synthesis of moracin M and cicerfuran, and the first time synthesis of moracin D and moracin E along with chromene-fused benzofuran-based natural products in overall good yields.

Organic & Biomolecular Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fernandez-Ramos, M. D. published the artcileOptical portable instrument for the determination of CO₂ in indoor environments, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Talanta (2020), 120387, database is CAplus and MEDLINE.

A portable device based on a colorimetric sensor to determine the atm. level of CO₂ gas is presented in this work. The system is based on a low-cost, low-power System on a Chip (SoC) microcontroller with integrated Wi-Fi. A user-friendly application was developed to monitor and log the CO₂ measurements when the system is connected to a Wi-Fi network. The sensing membrane is directly deposited on the surface of the color detector, thus reducing the complexity of the system. This sensing membrane is formed by a pH indicator α-naphtholphthalein, tetramethylammonium hydroxide pentahydrate, 1-ethyl-3-methylimidazolium tetrafluoroborate, Tween 20 and hydroxypropyl methylcellulose as the hydrophilic polymer. The system has been fully characterized, obtaining response and recovery times of 1.3 and 2.5 s, resp., a limit of detection of 51 ppm, and an average resolution of 6.3 ppm. This portable device was applied for the in-situ determination of CO₂ gas in the atm. inside classrooms in several secondary schools. The measurements were taken during complete workdays and the results were statistically compared with the same measurements taken using a com. available non-dispersive infra-red (NDIR) device. No significant statistical differences were found between the results obtained using both devices. A complete statistical treatment of the measurements made with the proposed portable device was carried out. The obtained results show that the concentration of CO₂ gas in some schools was higher than the desired concentration, with regard to influencing the student’s health, safety, productivity and comfort. This demonstrates the need to control this parameter to ensure appropriate indoor environmental quality (IEQ).

Talanta published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wu, Deyan published the artcileTotal synthesis of the 2-(aryl)benzo[b]furan-containing natural products from Artocarpus, COA of Formula: C14H10O4, the publication is Tetrahedron Letters (2015), 56(29), 4383-4387, database is CAplus.

In this study, 2-arylbenzo[b]furan-containing derivatives [i.e., moracin C and moracin M natural products from Artocarpus] have been synthesized in highest overall yield to date (1-7 steps with an overall yield of 41.9%; 4-6 steps with an overall yield of 56.3%). The authors also report the first total synthesis of artoindonesianin B-1 another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of (aryl)benzo[b]furan-containing natural product-like analogs to explore their biol. potential.

Tetrahedron Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C8H7NO4, COA of Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Gorski, Krzysztof published the artcileEfficient synthesis of 5-oxatruxene and the unusual influence of oxygen heteroatom on its physico-chemical properties, COA of Formula: C8H5IO, the publication is New Journal of Chemistry (2018), 42(8), 5844-5852, database is CAplus.

In this paper, the effective synthesis of oxatruxene and its photophys., electrochem. and structural features that transpire when a methylene unit in a truxene core is replaced by an oxygen atom to yield 5-oxatruxene is described. This modification broke the C_3h symmetry and at the same time introduced a more electroneg. structure as revealed by a four-fold increase in the quantum yield as compared to truxene. The derivatives of this material have great potential in optoelectronic devices and in organic photovoltaics. This proposed new synthetic method can be used to introduce other heteroatoms into the truxene system.

New Journal of Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kruglyak, A. I. published the artcileBehavior of phthalein and sulfophthalein indicators in ethylenediamine-methanol solutions, SDS of cas: 596-01-0, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1986), 52(11), 1192-7, database is CAplus.

The behavior of phenol red, bromophenol red, bromophenol blue, thymol blue, phenolphthalein, thymolphthalein, α-naphtholphthalein, and erythrosine in H₂NCH₂CH₂NH₂ (I)-MeOH and Et₂NH-MeOH solutions was studied at 293 K by IR and visible spectrophotometry. The basicity of binary solvent mixtures was examined in relation to the ratio of the conjugated ionic indicator forms. Basicity at low concentrations of I is enhanced as a result of intermol. interactions with MeOH. Solvatochromic effects are also discussed.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, SDS of cas: 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ilagouma, A. T. published the artcileArylcyclohexylamines derived from BTCP are potent indirect catecholamine agonists, Category: benzofurans, the publication is European Journal of Medicinal Chemistry (1993), 28(5), 377-85, database is CAplus.

N-[1-(2-Benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP)-related mols., e.g. I (R¹ = 2-benzo[b]thiophenyl, 2-benzo[b]furanyl, 2-naphthyl, 1-naphthyl, R² = H, 3-Me, 3,5-Me₂, 4-Me, 3-HOCH₂, 3-AcOCH₂, 4-BrCH₂, 3-ICH₂, 3-ClCH₂, R³ = H, 2-Me, 3-Me, 4-Me, 4-CMe₃) were prepared by chem. modulation of the 3 rings which constitute this dopamine (DA) and norepinephrine (NE) uptake inhibitor. The prepared compounds showed good homogeneity of action when tested in vitro [binding to the DA uptake complex and to the phencyclidine (PCP) receptor sites, inhibition of the synaptosomal uptake of DA and NE] and in vivo (locomotor activity in mice). The newly prepared structures, although formally related to the PCP structural model, no longer display significant affinity for the PCP receptor. These compounds behave like a new series of indirect potent stimulants of the dopaminergic and noradrenergic systems leading to potential antidepressive compounds

European Journal of Medicinal Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem