Day: November 21, 2022

Mazimba, Ofentse published the artcileAntioxidant and antibacterial constituents from Morus nigra, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is African Journal of Pharmacy and Pharmacology (2011), 5(6), 751-754, database is CAplus.

Constituents of the local Morus nigra L. (Black mulberry)were isolated and constituents were compared with other studied Mulberries and to evaluate its anti-oxidative and anti-bacterial activities. The isolated compounds were identified by comparison of spectral data (UV, IR, MS and NMR) with literature values. The stem bark and wood of M. nigra yielded a stilbenoid oxyresveratrol 1, a 2-arylbenzofuran moracin M2, four isoprenylated flavonoids; cyclomorusin 3, morusin 4, kuwanon C5 and a derivative of kuwanon C6, two tritepenes; betulinic acid 7, α-amyrin acetate 8 and a steroidal saponin β-sitosterol-3-O-β–glucoside 9. The phenolic isolates showed moderate DPPH radical scavenging activity (EC₅₀ = 23-135 μgml^-1) compared to ascorbic acid (EC₅₀ = 41 μgml^-1) after 30 min. Compounds 1, 2 and 4 to 6 showed activities against Staphylococcus aureus, Bacillus subtilis, Micrococus flavus, Streptococcus faecalis, Salmonella abony, Pseudomonas aeruginosa.

African Journal of Pharmacy and Pharmacology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Aelenei, Petruta published the artcileMorus alba leaf extract: Metabolite profiling and interactions with antibiotics against Staphylococcus spp. including MRSA, SDS of cas: 56317-21-6, the publication is Phytochemistry Letters (2019), 217-224, database is CAplus.

HPLC-DAD-ESI-Q-TOF-MS/MS metabolite profiling of Morus alba leaf extract led to the annotation of 25 constituents (two stilbene derivatives, 11 prenylflavonoids, five 2-arylbenzofurans, seven Diels-Alder type adducts). The extract was found to contain 57.83 mg/g flavonoids, 15.42 mg/g kuwanon G and 10.47 mg/g morusin. Despite its moderate antibacterial activity with min. inhibitory concentration (MIC) values of 250μg/mL against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591 and ATCC 43300, methicillin-susceptible S. aureus (MSSA) ATCC 6538 and S. epidermidis ATCC 12228, Morus alba leaf extract reversed oxacillin-resistance of MRSA ATCC 43300. In addition, the extract showed synergy with gentamicin against MRSA ATCC 33591 and ATCC 43300 and S. epidermidis ATCC 12228, oxacillin against MRSA ATCC 33591 and tetracycline against S. epidermidis ATCC 12228. In these synergistic combinations, MIC values of antibiotics were significantly decreased (4-32-fold). These findings might be valuable for the development of novel treatment strategies in infections caused by MRSA and S. epidermidis.

Phytochemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Nguyen, Thi Thanh Binh published the artcileSynthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4, Category: benzofurans, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7227-7231, database is CAplus and MEDLINE.

A novel series of combretastatin A-4 heterocyclic analogs was prepared by replacement of the B ring with indole, benzofuran or benzothiophene, attached at the C2 position. These compounds were evaluated for their abilities to inhibit tubulin assembly: derivative cis-I, having a benzothiophene, showed an activity similar to those of colchicine or deoxypodophyllotoxin. The antiproliferative and antimitotic properties of cis-I against keratinocyte cancer cell lines were also evaluated and the intracellular organization of microtubules in the cells after treatment with both stereoisomers of I was also determined, using confocal microscopy.

Bioorganic & Medicinal Chemistry Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Nguyen, Thi Thanh Binh published the artcileSynthesis of (Z) isomers of benzoheterocyclic derivatives of combretastatin A-4: a comparative study of several methods, COA of Formula: C8H5IO, the publication is Tetrahedron (2013), 69(10), 2336-2347, database is CAplus.

Several methods for the preparation of (Z) trimethoxystyrene derivatives I [R = H, X = O, S, N-Boc, NH; R = OMe, NO₂, X = S] & II were investigated. After finding that the Wittig reaction led to unsatisfactory results, three different strategies were considered: a Suzuki coupling with a stereodefined monobromoalkene, a combination of hydrosilylation/vinylsilane hydrolysis and a palladium-catalyzed semi-hydrogenation step, using DMF/KOH as the hydrogen source. Our studies led us to prepare a series of diarylacetylene derivatives via a Sonogashira coupling reaction, and also to find out a copper-free basic cyclization leading to benzo[b]thiophenes. The final choice for the synthesis method of I & II strongly depends on the target compound but the semi-hydrogenation, which avoids the use of a toxic tin reducing agent, should be generally preferred.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ko, Wonmin published the artcileKuwanon T and Sanggenon A Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells, Application In Synthesis of 56317-21-6, the publication is Molecules (2021), 26(24), 7642, database is CAplus and MEDLINE.

We previously investigated the methanolic extract of Morus alba bark and characterized 11 compounds from the extract: kuwanon G (1), kuwanon E (2), kuwanon T (3), sanggenon A (4), sanggenon M (5), sanggenol A (6), mulberofuran B (7), mulberofuran G (8), moracin M (9), moracin O (10), and norartocarpanone (11). Herein, we investigated the anti-inflammatory effects of these compounds on microglial cells (BV2) and macrophages (RAW264.7). Among them, 3 and 4 markedly inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide in these cells, suggesting the anti-inflammatory properties of these two compounds These compounds inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-α, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 following LPS stimulation. Pretreatment with 3 and 4 inhibited the activation of the nuclear factor kappa B signaling pathway in both cell types. The compounds also induced the expression of heme oxygenase (HO)-1 through the activation of nuclear factor erythroid 2-related factor 2. Suppressing the activity of HO-1 reversed the anti-inflammatory effects caused by pretreatment with 3 and 4, suggesting that the anti-inflammatory effects were regulated by HO-1. Taken together, 3 and 4 are potential candidates for developing therapeutic and preventive agents for inflammatory diseases.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Jing published the artcileQuantitative analysis of flavonoids in different medicinal parts of Morus alba, Formula: C14H10O4, the publication is Zhongguo Yaofang (2014), 25(27), 2550-2552, database is CAplus.

The aim is to determine contents of total flavonoids in leaves, fruit, branch and root bark of Morus alba. With moracin as substance control, the contents of total flavonoids in 95% ethanol extract, water extract after ethanol extraction from the leaves, fruit, branch and root bark of M.alba were measured by spectrophotometry. The linear range of moracin was 0.025-0.050mg/mL(r=0.9998). RSD of precision, stability and reproducibility tests were all lower than 1%. The mass fraction of total flavonoids in 95% ethanol extract from the leaves, fruit, branch and root bark of M. alba was 13.60%, 7.19%, 10.53% and 18.38%. The mass fraction of total flavonoids in water extract after ethanol extraction from the leaves, fruit, branch and root bark of M. alba was 0.26%, 0.60%, 0.40% and 0.01%. The content of total flavonoids in root bark of M. alba is the highest, ethanol extract of it is effective.

Zhongguo Yaofang published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C5H10O2S, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zheng, Jian published the artcile1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-Promoted Decomposition of Difluorocarbene and the Subsequent Trifluoromethylation, Name: 2-Iodobenzofuran, the publication is Organic Letters (2015), 17(3), 532-535, database is CAplus and MEDLINE.

Difluorocarbene derived from various carbene precursors could be effectively decomposed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). This decomposition process was successfully applied in the subsequent trifluoromethylation of a variety of (hetero)aryl iodides without the addition of an external fluoride ion. Mechanistic investigation revealed the detailed difluorocarbene conversion process in which the decomposed difluorocarbene is finally transformed into a fluoride ion and carbon monoxide.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C9H17NO, Name: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Che, Minghui published the artcileHPLC method for determination of related substances in escitalopram oxalate citalopram tablets, Synthetic Route of 372941-54-3, the publication is Heilongjiang Yiyao (2015), 28(1), 65-69, database is CAplus.

Objective: To establish an HPLC method for determination of escitalopram oxalate citalopram on material test. Methods: The stationary phase was Agilent C₁₈ (150 mm × 4.5 mm, 5 μm); the mobile phase was (1.5 g, sodium acetate and 0.4 mL glacial acetic acid to dissolve 1 L water, adding 1 M NaOH to adjust pH 5.2 buffer) methanol and acetonitrile-buffer (33:7:60); the flow rate was 1.0 mL/min; the detection wavelength was 239 nm; and the sample quantity was 10 μL. Results: Under the chromatog. conditions, the principal components and the related materials were completely separated, and the separating degree of all impurities was in good condition. In 0.375-3 μg/mL, 0.621-4.91 μg/mL and 4.91-4.90 μg/mL, three main relevant materials had good linear relationship between peak area and concentration, and the average recovery conformed to specified requirements. Conclusion: This method is simple and reproducible and it can be used for quality control of escitalopram oxalate citalopram tablets.

Heilongjiang Yiyao published new progress about 372941-54-3. 372941-54-3 belongs to benzofurans, auxiliary class Other Aliphatic Heterocyclic,Fluoride,Nitrile,Amine,Benzene,Ester, name is 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile, and the molecular formula is C20H19FN2O2, Synthetic Route of 372941-54-3.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Fuyi published the artcileSynthesis of het(aryl) imidazole C-nucleoside analogues by CoFe₂O₄ NPs catalyzed muti-component coupling reaction, Application of 2-Iodobenzofuran, the publication is Carbohydrate Research (2019), 39-50, database is CAplus and MEDLINE.

A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogs has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO₄/TBAB oxidation and CoFe₂O₄ NPs catalyzed multi-component coupling of the corresponding diketones, NH₄OAc and aromatic aldehydes in one-pot. The sugar alkynes include pyranosides and furanosides with acid sensitive protecting groups. The het(aryl) iodides comprise iodoaroms., iodoheterocycles, and sterically hindered iodoheteroaroms.

Carbohydrate Research published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C18H10, Application of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Shuwen published the artcileFacile functionalization at the C2 position of a highly substituted benzofuran, Safety of 2-Iodobenzofuran, the publication is Tetrahedron Letters (2014), 55(14), 2212-2216, database is CAplus.

To expedite an SAR study on C(2) of a highly substituted benzofuran ring system, a method for the preparation of a key precursor, iodide I, was developed. From I, a diverse set of compounds with different substituents at C(2) were prepared efficiently by Suzuki reaction.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Safety of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem