Che, Minghui published the artcileHPLC method for determination of related substances in escitalopram oxalate citalopram tablets, Synthetic Route of 372941-54-3, the publication is Heilongjiang Yiyao (2015), 28(1), 65-69, database is CAplus.
Objective: To establish an HPLC method for determination of escitalopram oxalate citalopram on material test. Methods: The stationary phase was Agilent C18 (150 mm × 4.5 mm, 5 μm); the mobile phase was (1.5 g, sodium acetate and 0.4 mL glacial acetic acid to dissolve 1 L water, adding 1 M NaOH to adjust pH 5.2 buffer) methanol and acetonitrile-buffer (33:7:60); the flow rate was 1.0 mL/min; the detection wavelength was 239 nm; and the sample quantity was 10 μL. Results: Under the chromatog. conditions, the principal components and the related materials were completely separated, and the separating degree of all impurities was in good condition. In 0.375-3 μg/mL, 0.621-4.91 μg/mL and 4.91-4.90 μg/mL, three main relevant materials had good linear relationship between peak area and concentration, and the average recovery conformed to specified requirements. Conclusion: This method is simple and reproducible and it can be used for quality control of escitalopram oxalate citalopram tablets.
Heilongjiang Yiyao published new progress about 372941-54-3. 372941-54-3 belongs to benzofurans, auxiliary class Other Aliphatic Heterocyclic,Fluoride,Nitrile,Amine,Benzene,Ester, name is 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile, and the molecular formula is C20H19FN2O2, Synthetic Route of 372941-54-3.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem